donepezil has been researched along with Chronic Disease in 12 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil does not seem to improve negative signs and cognitive impairment in elderly patients with chronic schizophrenia." | 9.12 | Donepezil for negative signs in elderly patients with schizophrenia: an add-on, double-blind, crossover, placebo-controlled study. ( Barak, Y; Mazeh, D; Mirecki, I; Paleacu, D; Zemishlani, H, 2006) |
| "To study the effects of acetylcholinesterase inhibitors (AChEIs) in the management of cognitive impairments in patients with schizophrenia, we investigated the effects of 12 weeks of adjunctive therapy with donepezil on their cognitive impairments." | 9.12 | A 12-week, double-blind, placebo-controlled trial of donepezil as an adjunct to haloperidol for treating cognitive impairments in patients with chronic schizophrenia. ( Kim, YH; Lee, BJ; Lee, JG, 2007) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 7.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| "Donepezil treatment started 14 days after MI significantly decreased the heart rate (325 ± 6 vs." | 5.39 | Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. ( Inagaki, M; Kawada, T; Li, M; Shishido, T; Sugimachi, M; Uemura, K; Zheng, C, 2013) |
| "Donepezil does not seem to improve negative signs and cognitive impairment in elderly patients with chronic schizophrenia." | 5.12 | Donepezil for negative signs in elderly patients with schizophrenia: an add-on, double-blind, crossover, placebo-controlled study. ( Barak, Y; Mazeh, D; Mirecki, I; Paleacu, D; Zemishlani, H, 2006) |
| "To study the effects of acetylcholinesterase inhibitors (AChEIs) in the management of cognitive impairments in patients with schizophrenia, we investigated the effects of 12 weeks of adjunctive therapy with donepezil on their cognitive impairments." | 5.12 | A 12-week, double-blind, placebo-controlled trial of donepezil as an adjunct to haloperidol for treating cognitive impairments in patients with chronic schizophrenia. ( Kim, YH; Lee, BJ; Lee, JG, 2007) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 3.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| "Donepezil treatment started 14 days after MI significantly decreased the heart rate (325 ± 6 vs." | 1.39 | Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. ( Inagaki, M; Kawada, T; Li, M; Shishido, T; Sugimachi, M; Uemura, K; Zheng, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takamiya, A | 1 |
| Sawada, K | 1 |
| Hirano, J | 1 |
| Mimura, M | 1 |
| Kishimoto, T | 1 |
| Li, M | 2 |
| Zheng, C | 2 |
| Kawada, T | 2 |
| Inagaki, M | 2 |
| Uemura, K | 2 |
| Shishido, T | 1 |
| Sugimachi, M | 2 |
| Akhondzadeh, S | 1 |
| Gerami, M | 1 |
| Noroozian, M | 1 |
| Karamghadiri, N | 1 |
| Ghoreishi, A | 1 |
| Abbasi, SH | 1 |
| Rezazadeh, SA | 1 |
| Howard, AK | 1 |
| Thornton, AE | 1 |
| Altman, S | 1 |
| Honer, WG | 1 |
| Berthier, ML | 1 |
| Hinojosa, J | 1 |
| Martín, Mdel C | 1 |
| Fernández, I | 1 |
| Morey, CE | 1 |
| Cilo, M | 1 |
| Berry, J | 1 |
| Cusick, C | 1 |
| Mazeh, D | 1 |
| Zemishlani, H | 1 |
| Barak, Y | 1 |
| Mirecki, I | 1 |
| Paleacu, D | 1 |
| Thacker, EL | 1 |
| Schneeweiss, S | 1 |
| Lee, BJ | 1 |
| Lee, JG | 1 |
| Kim, YH | 1 |
| Obata, H | 1 |
| Hayashida, K | 1 |
| Masanic, CA | 1 |
| Bayley, MT | 1 |
| VanReekum, R | 1 |
| Simard, M | 1 |
1 review available for donepezil and Chronic Disease
| Article | Year |
|---|---|
[Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems].
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics; Animals; Brain-Derived Neur | 2007 |
4 trials available for donepezil and Chronic Disease
| Article | Year |
|---|---|
A 12-week, double-blind, placebo-controlled trial of donepezil adjunctive treatment to risperidone in chronic and stable schizophrenia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Donepezil; Double-Blind Method; Female; Humans; Indans | 2008 |
Donepezil for negative signs in elderly patients with schizophrenia: an add-on, double-blind, crossover, placebo-controlled study.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Chronic Disease; Cognition Disorders; Comorbidity; Cr | 2006 |
A 12-week, double-blind, placebo-controlled trial of donepezil as an adjunct to haloperidol for treating cognitive impairments in patients with chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Cholinesterase Inhibitors; Chronic Disease; Cognition Disorders; Donepe | 2007 |
Open-label study of donepezil in traumatic brain injury.
Topics: Adult; Brain Injuries; Chronic Disease; Donepezil; Humans; Indans; Male; Memory Disorders; Mental Di | 2001 |
7 other studies available for donepezil and Chronic Disease
| Article | Year |
|---|---|
Prolonged Post-Electroconvulsive Therapy Delirium Controlled With Donepezil.
Topics: Bipolar Disorder; Chronic Disease; Delirium; Donepezil; Electroconvulsive Therapy; Female; Humans; M | 2019 |
Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction.
Topics: Animals; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Heart Failure; Indans; Male; Myocard | 2013 |
Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cholinesterase Inhibitors; Chronic Disease; Diseas | 2014 |
Donepezil for memory dysfunction in schizophrenia.
Topics: Antipsychotic Agents; Chronic Disease; Dibenzothiazepines; Donepezil; Drug Therapy, Combination; Fem | 2002 |
Open-label study of donepezil in chronic poststroke aphasia.
Topics: Adult; Aged; Aphasia; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Female; Humans; Indans; | 2003 |
The effect of Aricept in persons with persistent memory disorder following traumatic brain injury: a pilot study.
Topics: Adult; Analysis of Variance; Brain Injuries; Cholinesterase Inhibitors; Chronic Disease; Donepezil; | 2003 |
Initiation of acetylcholinesterase inhibitors and complications of chronic airways disorders in elderly patients.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Chronic Disease; Cross-Over Studies; Donepezil; | 2006 |