donepezil has been researched along with Cholera Infantum in 7 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The safety and efficacy of a novel combination treatment of AChE inhibitors and choline supplement was initiated and evaluated in children and adolescents with autism spectrum disorder (ASD)." | 9.30 | Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment. ( Ben-Hur, R; Gabis, LV; Jokel, A; Shalom, DB; Shefer, S, 2019) |
| "To evaluate the efficacy of donepezil in patients with early-stage Alzheimer disease." | 9.11 | Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial. ( Goldman, R; Ieni, J; Kumar, D; Nunez, M; Richardson, S; Seltzer, B; Zolnouni, P, 2004) |
| "Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear." | 6.77 | Cardiac safety of donepezil in elderly patients with Alzheimer disease. ( Aydemir, E; Bozoglu, E; Isik, AT; Yay, A; Yildiz, GB, 2012) |
| "The safety and efficacy of a novel combination treatment of AChE inhibitors and choline supplement was initiated and evaluated in children and adolescents with autism spectrum disorder (ASD)." | 5.30 | Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment. ( Ben-Hur, R; Gabis, LV; Jokel, A; Shalom, DB; Shefer, S, 2019) |
| "To evaluate the efficacy of donepezil in patients with early-stage Alzheimer disease." | 5.11 | Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial. ( Goldman, R; Ieni, J; Kumar, D; Nunez, M; Richardson, S; Seltzer, B; Zolnouni, P, 2004) |
| "Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear." | 2.77 | Cardiac safety of donepezil in elderly patients with Alzheimer disease. ( Aydemir, E; Bozoglu, E; Isik, AT; Yay, A; Yildiz, GB, 2012) |
| " Three head-to-head trials of ChEIs in the treatment of AD have been published to date, but are limited due to their open-label design, rates of titration, and the drug dosage levels utilised." | 2.42 | The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease. ( Herrmann, N; Lanctôt, KL; Thompson, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gabis, LV | 1 |
| Ben-Hur, R | 1 |
| Shefer, S | 1 |
| Jokel, A | 1 |
| Shalom, DB | 1 |
| Isik, AT | 1 |
| Yildiz, GB | 1 |
| Bozoglu, E | 1 |
| Yay, A | 1 |
| Aydemir, E | 1 |
| Relkin, NR | 1 |
| Reichman, WE | 1 |
| Orazem, J | 1 |
| McRae, T | 1 |
| Thompson, S | 1 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Seltzer, B | 1 |
| Zolnouni, P | 1 |
| Nunez, M | 1 |
| Goldman, R | 1 |
| Kumar, D | 1 |
| Ieni, J | 1 |
| Richardson, S | 1 |
| McCain, KR | 1 |
| Sawyer, TS | 1 |
| Spiller, HA | 1 |
| Rocca, P | 1 |
| Cocuzza, E | 1 |
| Marchiaro, L | 1 |
| Bogetto, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 6 Months, Prospective, Open-label, Observational, Non-interventional Clinical Trial to Examine the Efficacy and Safety of Donepezil (Dementis®) Administration in Patients With Dementia.[NCT01772095] | 389 participants (Actual) | Observational | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for donepezil and Cholera Infantum
| Article | Year |
|---|---|
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Ganglia Diseases; Bradycardia; Central Nervous System Diseas | 2004 |
4 trials available for donepezil and Cholera Infantum
| Article | Year |
|---|---|
Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment.
Topics: Adolescent; Autistic Disorder; Child; Choline; Donepezil; Drug Therapy, Combination; Female; Gastroi | 2019 |
Cardiac safety of donepezil in elderly patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Blood Pressure; Cholinesterase Inh | 2012 |
A large, community-based, open-label trial of donepezil in the treatment of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antidepr | 2003 |
Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chi-Square Distribution; Donepezil; Double-Blind Method; | 2004 |
2 other studies available for donepezil and Cholera Infantum
| Article | Year |
|---|---|
Evaluation of centrally acting cholinesterase inhibitor exposures in adults.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gastroint | 2007 |
Donepezil in the treatment of Alzheimer's disease: long-term efficacy and safety.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Donepezil; Female; Gastrointestinal Diseases; H | 2002 |