donepezil has been researched along with Cardiovascular Stroke in 9 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacological modulation of parasympathetic activity with donepezil, an acetylcholinesterase inhibitor, improves the long-term survival of rats with chronic heart failure (CHF) after myocardial infarction (MI)." | 8.02 | Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. ( Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2021) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 7.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| "We have previously demonstrated that the chronic intervention in the cholinergic system by donepezil, an acetylcholinesterase inhibitor, plays a beneficial role in suppressing long-term cardiac remodeling after myocardial infarction (MI)." | 7.77 | Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice. ( Arikawa, M; Handa, T; Kakinuma, Y; Sato, T; Yamasaki, F, 2011) |
| "Donepezil treatment started 14 days after MI significantly decreased the heart rate (325 ± 6 vs." | 5.39 | Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. ( Inagaki, M; Kawada, T; Li, M; Shishido, T; Sugimachi, M; Uemura, K; Zheng, C, 2013) |
| "Pharmacological modulation of parasympathetic activity with donepezil, an acetylcholinesterase inhibitor, improves the long-term survival of rats with chronic heart failure (CHF) after myocardial infarction (MI)." | 4.02 | Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. ( Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2021) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 3.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| "We have previously demonstrated that the chronic intervention in the cholinergic system by donepezil, an acetylcholinesterase inhibitor, plays a beneficial role in suppressing long-term cardiac remodeling after myocardial infarction (MI)." | 3.77 | Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice. ( Arikawa, M; Handa, T; Kakinuma, Y; Sato, T; Yamasaki, F, 2011) |
| "Donepezil plays a neuroprotective role in I/R‑associated diseases." | 1.72 | Donepezil ameliorates oxygen‑glucose deprivation/reoxygenation‑induced cardiac microvascular endothelial cell dysfunction through PARP1/NF‑κB signaling. ( Li, Y; Sun, X; Wang, J; Yang, C; Zhuang, J, 2022) |
| "Donepezil treatment started 14 days after MI significantly decreased the heart rate (325 ± 6 vs." | 1.39 | Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. ( Inagaki, M; Kawada, T; Li, M; Shishido, T; Sugimachi, M; Uemura, K; Zheng, C, 2013) |
| "Memantine was also associated with greater risk of all-cause mortality in the Medicare (HR = 1." | 1.38 | Comparative cardiovascular safety of dementia medications: a cross-national study. ( Curtis, LH; Fosbøl, EL; Gislason, GH; Holm, E; Iwata, I; Køber, L; Peterson, ED; Setoguchi, S; Torp-Pedersen, C; Zhang, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Sun, X | 1 |
| Zhuang, J | 1 |
| Wang, J | 1 |
| Yang, C | 1 |
| Li, M | 5 |
| Zheng, C | 5 |
| Kawada, T | 4 |
| Uemura, K | 4 |
| Inagaki, M | 4 |
| Saku, K | 1 |
| Sugimachi, M | 5 |
| Akiyama, T | 1 |
| Khuanjing, T | 1 |
| Palee, S | 1 |
| Kerdphoo, S | 1 |
| Jaiwongkam, T | 1 |
| Anomasiri, A | 1 |
| Chattipakorn, SC | 1 |
| Chattipakorn, N | 1 |
| Shishido, T | 1 |
| Okazaki, Y | 1 |
| Arikawa, M | 1 |
| Kakinuma, Y | 1 |
| Handa, T | 1 |
| Yamasaki, F | 1 |
| Sato, T | 1 |
| Fosbøl, EL | 1 |
| Peterson, ED | 1 |
| Holm, E | 1 |
| Gislason, GH | 1 |
| Zhang, Y | 1 |
| Curtis, LH | 1 |
| Køber, L | 1 |
| Iwata, I | 1 |
| Torp-Pedersen, C | 1 |
| Setoguchi, S | 1 |
9 other studies available for donepezil and Cardiovascular Stroke
| Article | Year |
|---|---|
Donepezil ameliorates oxygen‑glucose deprivation/reoxygenation‑induced cardiac microvascular endothelial cell dysfunction through PARP1/NF‑κB signaling.
Topics: Adolescent; Adult; Apoptosis; Cell Line; Cell Survival; Donepezil; Endothelial Cells; Female; Glucos | 2022 |
Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Donepezil; Heart Failure; Metoprolol; Myocardial Infarction; R | 2022 |
Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Cholinesterase Inhibito | 2021 |
Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy.
Topics: Animals; Autophagy; Cholinesterase Inhibitors; Donepezil; Male; Mitochondria, Heart; Mitophagy; Myoc | 2021 |
Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction.
Topics: Animals; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Heart Failure; Indans; Male; Myocard | 2013 |
Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cholinesterase Inhibitors; Chronic Disease; Diseas | 2014 |
Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Heart; Heart Failure; Heart Rate; Indans; Male; Myoca | 2010 |
Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice.
Topics: Alzheimer Disease; Animals; Blood Pressure; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; E | 2011 |
Comparative cardiovascular safety of dementia medications: a cross-national study.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cohort Studies; Dementia; Denmark; Donepezil; Fe | 2012 |