donepezil has been researched along with Cardiotoxicity in 6 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Cardiotoxicity: Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since cardiac autonomic modulation with electrical vagus nerve stimulation (VNS) and acetylcholinesterase (AChE) inhibitors exerts cardioprotection against various heart diseases, the comparative effects of electrical VNS and an AChE inhibitor (donepezil) on cardiac and mitochondrial functions and programmed cell death pathways in TIC are not known." | 8.31 | Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N, 2023) |
| "Donepezil exerted cardioprotection against TIC via attenuating mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte death, leading to improved LV function through mAChR activation." | 4.31 | Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N, 2023) |
| " Since cardiac autonomic modulation with electrical vagus nerve stimulation (VNS) and acetylcholinesterase (AChE) inhibitors exerts cardioprotection against various heart diseases, the comparative effects of electrical VNS and an AChE inhibitor (donepezil) on cardiac and mitochondrial functions and programmed cell death pathways in TIC are not known." | 4.31 | Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N, 2023) |
| " We therefore examined the electrophysiologic profile of donepezil, rivastigmine, and galantamine in a sensitive whole-heart model of proarrhythmia." | 3.96 | Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model. ( Coenen, A; Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Leitz, P; Niehues, P, 2020) |
| "Clinical reports indicate that cardiotoxicity due to donepezil can occur after coadministration with cilostazol." | 3.83 | Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart. ( Nakanishi, T; Shinozaki, K; Takeuchi, R; Tamai, I, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Khuanjing, T | 3 |
| Ongnok, B | 3 |
| Maneechote, C | 3 |
| Siri-Angkul, N | 1 |
| Prathumsap, N | 3 |
| Arinno, A | 3 |
| Chunchai, T | 3 |
| Arunsak, B | 3 |
| Chattipakorn, SC | 4 |
| Chattipakorn, N | 4 |
| Osataphan, N | 1 |
| Phrommintikul, A | 1 |
| Leemasawat, K | 1 |
| Somwangprasert, A | 1 |
| Apaijai, N | 1 |
| Suksai, S | 1 |
| Sirikul, W | 1 |
| Gunaparn, S | 1 |
| Ellermann, C | 1 |
| Coenen, A | 1 |
| Niehues, P | 1 |
| Leitz, P | 1 |
| Kochhäuser, S | 1 |
| Dechering, DG | 1 |
| Fehr, M | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Takeuchi, R | 1 |
| Shinozaki, K | 1 |
| Nakanishi, T | 1 |
| Tamai, I | 1 |
1 trial available for donepezil and Cardiotoxicity
| Article | Year |
|---|---|
Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer: a randomized controlled trial.
Topics: Breast Neoplasms; Cardiotoxicity; Donepezil; Doxorubicin; Female; Humans; Leukocytes, Mononuclear; M | 2023 |
5 other studies available for donepezil and Cardiotoxicity
| Article | Year |
|---|---|
Acetylcholinesterase inhibitor ameliorates doxorubicin-induced cardiotoxicity through reducing RIP1-mediated necroptosis.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Cardiotoxicity; Cell Line; Cholinesteras | 2021 |
Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways.
Topics: Acetylcholinesterase; Animals; Apoptosis; Cardiotoxicity; Donepezil; Inflammation; Male; Rats; Rats, | 2023 |
Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction.
Topics: Acetylcholinesterase; Animals; Cardiotoxicity; Cholinesterase Inhibitors; Donepezil; Heart Diseases; | 2023 |
Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiotoxicity; Cholinesterase Inhibitors; Donepez | 2020 |
Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart.
Topics: Acridines; Administration, Intravenous; Administration, Oral; Animals; ATP Binding Cassette Transpor | 2016 |