donepezil has been researched along with Brain Neoplasms in 10 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Studies in early radiotherapy treatment phase (five studies) Pharmacological studies in the "early radiotherapy treatment phase" were designed to prevent or ameliorate cognitive deficits and included drugs used in dementia (memantine) and fatigue (d-threo-methylphenidate hydrochloride)." | 5.22 | Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation. ( Brown, PD; Day, J; Gehring, K; Grosshans, D; Kirkman, MA; Li, J; Taphoorn, M; Zienius, K, 2022) |
| "Treatment with donepezil did not significantly improve the overall composite score, but it did result in modest improvements in several cognitive functions, especially among patients with greater pretreatment impairments." | 2.80 | Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial. ( Case, LD; Chan, MD; Edenfield, WJ; Falchuk, SC; Giguere, JK; Loghin, ME; Moore, DF; Naughton, MM; Peiffer, A; Piephoff, JV; Rapp, SR; Shaw, EG; Stieber, VW, 2015) |
| "All 24 patients had a primary brain tumor, mostly low-grade glioma." | 2.72 | Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. ( D'Agostino, RB; Lovato, J; Naughton, MJ; Rapp, SR; Robbins, ME; Rosdhal, R; Shaw, EG, 2006) |
| "Many patients with brain cancer experience cognitive problems." | 2.61 | Interventions for cognitive problems in adults with brain cancer: A narrative review. ( Gehring, K; Klaver, KM; Schagen, SB; Sitskoorn, MM; van Lonkhuizen, PJC; Wefel, JS, 2019) |
| "Survivors of childhood cancer frequently experience cancer-related cognitive dysfunction, commonly months to years after treatment for pediatric brain tumors, acute lymphoblastic leukemia (ALL), or tumors involving the head and neck." | 2.50 | Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors. ( Castellino, SM; Lange, BJ; Ullrich, NJ; Whelen, MJ, 2014) |
| "Donepezil was well tolerated among childhood BT survivors who had received substantial prior therapy." | 1.38 | Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. ( Castellino, SM; Flowers, L; Hill, DF; McMullen, KP; Parsons, SK; Shaw, EG; Tooze, JA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kirkman, MA | 3 |
| Day, J | 3 |
| Gehring, K | 4 |
| Zienius, K | 3 |
| Grosshans, D | 3 |
| Taphoorn, M | 3 |
| Li, J | 3 |
| Brown, PD | 3 |
| Nepali, K | 1 |
| Wu, AC | 1 |
| Lo, WL | 1 |
| Chopra, B | 1 |
| Lai, MJ | 1 |
| Chuang, JY | 1 |
| Liou, JP | 1 |
| van Lonkhuizen, PJC | 1 |
| Klaver, KM | 1 |
| Wefel, JS | 1 |
| Sitskoorn, MM | 1 |
| Schagen, SB | 1 |
| Castellino, SM | 2 |
| Ullrich, NJ | 1 |
| Whelen, MJ | 1 |
| Lange, BJ | 1 |
| Rapp, SR | 2 |
| Case, LD | 1 |
| Peiffer, A | 1 |
| Naughton, MM | 1 |
| Chan, MD | 1 |
| Stieber, VW | 1 |
| Moore, DF | 1 |
| Falchuk, SC | 1 |
| Piephoff, JV | 1 |
| Edenfield, WJ | 1 |
| Giguere, JK | 1 |
| Loghin, ME | 1 |
| Shaw, EG | 3 |
| Correa, DD | 1 |
| Kryza-Lacombe, M | 1 |
| Baser, RE | 1 |
| Beal, K | 1 |
| DeAngelis, LM | 1 |
| Ishiuchi, S | 1 |
| Tooze, JA | 1 |
| Flowers, L | 1 |
| Hill, DF | 1 |
| McMullen, KP | 1 |
| Parsons, SK | 1 |
| Rosdhal, R | 1 |
| D'Agostino, RB | 1 |
| Lovato, J | 1 |
| Naughton, MJ | 1 |
| Robbins, ME | 1 |
| McCaffrey, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MentalPlus® for Assessment and Rehabilitation of Cognitive Functions After Remission of Symptoms of COVID-19[NCT04632719] | 200 participants (Anticipated) | Interventional | 2020-11-08 | Recruiting | |||
| UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases: Avoidance of Eloquent White Matter and Hippocampal Regions[NCT04343157] | Phase 2 | 60 participants (Anticipated) | Interventional | 2019-05-01 | Recruiting | ||
| Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases[NCT00070161] | Phase 2 | 68 participants (Actual) | Interventional | 2001-07-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for donepezil and Brain Neoplasms
| Article | Year |
|---|---|
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Brain Neoplasms; Cognition; Cognitive Dysfunction; Cranial Irradiation; Dementia; Donepezil; | 2022 |
Interventions for cognitive problems in adults with brain cancer: A narrative review.
Topics: Brain Neoplasms; Central Nervous System Stimulants; Cholinesterase Inhibitors; Cognition; Cognitive | 2019 |
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Br | 2014 |
[Diagnosis and treatment of cognitive deficits caused by radiation in patients with brain tumours].
Topics: Animals; Biomarkers; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Cytokines; Don | 2011 |
2 trials available for donepezil and Brain Neoplasms
| Article | Year |
|---|---|
Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Com | 2015 |
Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life.
Topics: Adult; Affect; Aged; Anger; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Donepez | 2006 |
4 other studies available for donepezil and Brain Neoplasms
| Article | Year |
|---|---|
Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Donepezil; Glioblastoma; Histone Dea | 2023 |
Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cholinesterase Inhibitors; Cognition; Cognition Dis | 2016 |
Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Child; Cholinesterase Inhibitors; Cogniti | 2012 |
Alzheimer's drug helps brain function after radiotherapy.
Topics: Alzheimer Disease; Brain Neoplasms; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents | 2006 |