donepezil has been researched along with Brain Ischemia in 13 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the effects of donepezil hydrochloride (DH) on the expression of the calpain I-cyclin-dependent kinase5/p25 (CDK5/p25) pathway in the hippocampal CA1 region in mice with cerebral ischemia-reperfusion (I/R)." | 7.80 | Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice. ( Fan, M; Jin, W; Lang, J; Lv, P; Wang, T; Zhang, H, 2014) |
| " In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils." | 7.78 | Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. ( Cai, J; Cao, Y; Chen, T; Guo, F; Mao, X; Min, D; Shaw, C; Wang, L; Wu, K; Xie, N; Zhu, S, 2012) |
| "Donepezil, a selective acetylcholinesterase (AchE) inhibitor, enhances stroke-induced neurogenesis within subventricular zone (SVZ)." | 3.96 | Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion. ( Cui, K; Fu, X; Gao, Y; Li, N; Lu, Z; Man, J; Wang, J; Yu, L; Zhang, D, 2020) |
| "The aim of this study was to investigate the effects of donepezil hydrochloride (DH) on the expression of the calpain I-cyclin-dependent kinase5/p25 (CDK5/p25) pathway in the hippocampal CA1 region in mice with cerebral ischemia-reperfusion (I/R)." | 3.80 | Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice. ( Fan, M; Jin, W; Lang, J; Lv, P; Wang, T; Zhang, H, 2014) |
| " In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils." | 3.78 | Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. ( Cai, J; Cao, Y; Chen, T; Guo, F; Mao, X; Min, D; Shaw, C; Wang, L; Wu, K; Xie, N; Zhu, S, 2012) |
| "After carotid stenosis was relieved, the cerebral blood flow values significantly increased, and P300 latency and escape latency in the Morris water-maze were significantly shortened." | 1.37 | Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion. ( Chen, KN; Chun-Qing, Z; Duan, W; Gui, L; Huang, HQ; Zheng, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Monjas, L | 1 |
| Arce, MP | 1 |
| León, R | 1 |
| Egea, J | 1 |
| Pérez, C | 1 |
| Villarroya, M | 1 |
| López, MG | 1 |
| Gil, C | 1 |
| Conde, S | 1 |
| Rodríguez-Franco, MI | 1 |
| Man, J | 1 |
| Cui, K | 1 |
| Fu, X | 1 |
| Zhang, D | 1 |
| Lu, Z | 1 |
| Gao, Y | 1 |
| Yu, L | 1 |
| Li, N | 1 |
| Wang, J | 1 |
| Nyitrai, G | 1 |
| Spisák, T | 1 |
| Spisák, Z | 1 |
| Gajári, D | 1 |
| Diószegi, P | 1 |
| Kincses, TZ | 1 |
| Czurkó, A | 1 |
| Wang, T | 1 |
| Lv, P | 1 |
| Jin, W | 1 |
| Zhang, H | 1 |
| Lang, J | 1 |
| Fan, M | 1 |
| Yamazaki, Y | 1 |
| Harada, S | 1 |
| Tokuyama, S | 1 |
| Ukai, K | 1 |
| Matsuo, K | 1 |
| Nakamura, R | 1 |
| Sobue, G | 1 |
| Kosaka, K | 1 |
| Shibayama, H | 1 |
| Iritani, S | 1 |
| Ishihara, R | 1 |
| Ozaki, N | 1 |
| Duan, W | 1 |
| Chun-Qing, Z | 1 |
| Zheng, J | 1 |
| Gui, L | 1 |
| Huang, HQ | 1 |
| Chen, KN | 1 |
| Min, D | 1 |
| Mao, X | 1 |
| Wu, K | 1 |
| Cao, Y | 1 |
| Guo, F | 1 |
| Zhu, S | 1 |
| Xie, N | 1 |
| Wang, L | 1 |
| Chen, T | 1 |
| Shaw, C | 1 |
| Cai, J | 1 |
| Xu, AJ | 1 |
| Chen, Z | 1 |
| Yanai, K | 1 |
| Huang, YW | 1 |
| Wei, EQ | 1 |
| Fukui, T | 1 |
| Taguchi, S | 1 |
| Lee, JH | 1 |
| Park, SY | 1 |
| Shin, YW | 1 |
| Kim, CD | 1 |
| Lee, WS | 1 |
| Hong, KW | 1 |
| Watanabe, T | 1 |
| Iwasaki, K | 1 |
| Ishikane, S | 1 |
| Naitou, T | 1 |
| Yoshimitsu, Y | 1 |
| Yamagata, N | 1 |
| Ozdemir, MB | 1 |
| Takasaki, K | 1 |
| Egashira, N | 1 |
| Mishima, K | 1 |
| Fujiwara, M | 1 |
| Higgins, GA | 1 |
| Enderlin, M | 1 |
| Fimbel, R | 1 |
| Haman, M | 1 |
| Grottick, AJ | 1 |
| Soriano, M | 1 |
| Richards, JG | 1 |
| Kemp, JA | 1 |
| Gill, R | 1 |
1 trial available for donepezil and Brain Ischemia
| Article | Year |
|---|---|
Do vascular lesions and related risk factors influence responsiveness to donepezil chloride in patients with Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Brain; Brain Ischemia; Cholinesterase Inhibitors; Cognition Disorders; Demo | 2005 |
12 other studies available for donepezil and Brain Ischemia
| Article | Year |
|---|---|
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Don | 2017 |
Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Brain Ischemia; Cell Proliferation; Cerebral Ventricles; Donepezil; Doublecortin Protein; F | 2020 |
Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes.
Topics: Animals; Brain Ischemia; Carotid Artery, Common; Carotid Stenosis; Cerebrovascular Circulation; Diff | 2018 |
Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice.
Topics: Animals; Brain Ischemia; Donepezil; Hippocampus; Humans; Indans; Malondialdehyde; Memory; Mice; Neur | 2014 |
Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage.
Topics: Acetylcholine; Animals; Animals, Outbred Strains; Astrocytes; Blood Glucose; Brain Ischemia; Choline | 2014 |
A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease.
Topics: Aged; Brain Ischemia; Cholinesterase Inhibitors; Creutzfeldt-Jakob Syndrome; Diagnosis, Differential | 2010 |
Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion.
Topics: Acetylcholine; Acoustic Stimulation; Analysis of Variance; Animals; Biogenic Monoamines; Brain Ische | 2011 |
Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cognition D | 2012 |
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Animals; Benzazepines; Brain; Brain Ischemia; Cholinesterase Inhibitors; Coloring Agents; Donepezil; | 2002 |
Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Choline O-Acetyltransferase; Cilostazol; Cognition | 2007 |
Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Cholines | 2008 |
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia.
Topics: Alzheimer Disease; Animals; Brain Infarction; Brain Ischemia; Cell Death; Cholinesterase Inhibitors; | 2002 |