donepezil has been researched along with Brain Injuries in 19 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Small studies performed in chronic stroke patients have indicated that single doses of reboxetine or citalopram improved different aspects of motor functions and that long-lasting application of donepezil reduced aphasic symptoms." | 4.84 | Pharmacotherapy in restorative neurology. ( Liepert, J, 2008) |
| "This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia." | 4.84 | Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature. ( Valdovinos, MG; Williams, DC; Yoo, JH, 2007) |
| " These data indicate that chronic administration of donepezil is not only ineffective in promoting functional improvement after moderate CCI injury, but depending on the dose is actually detrimental to the recovery process." | 1.39 | Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. ( Bondi, CO; Kline, AE; Light, SH; Massimino, LA; McAloon, RL; Monaco, CM; Shaw, KE, 2013) |
| "Donepezil is an acetylcholinesterase inhibitor that is used to treat Alzheimer's disease." | 1.35 | Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury. ( Abe, T; Fujiki, M; Hikawa, T; Ishii, K; Kamida, T; Kobayashi, H; Kubo, T; Sugita, K, 2008) |
| " A prospective, randomized, placebo-controlled clinical trial with standard timing, dosage and treatment duration is recommended to further evaluate treatment efficacy." | 1.32 | The effects of Donepezil on traumatic brain injury acute rehabilitation outcomes. ( Cornis-Pop, M; Gibellato, M; Jena, T; Lew, H; Seel, R; Silver, T; Walker, W, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 14 (73.68) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Ongnok, B | 1 |
| Khuanjing, T | 1 |
| Chunchai, T | 1 |
| Kerdphoo, S | 1 |
| Jaiwongkam, T | 1 |
| Chattipakorn, N | 1 |
| Chattipakorn, SC | 1 |
| Yu, TS | 1 |
| Kim, A | 1 |
| Kernie, SG | 1 |
| Liepert, J | 1 |
| Shaw, KE | 1 |
| Bondi, CO | 1 |
| Light, SH | 1 |
| Massimino, LA | 1 |
| McAloon, RL | 1 |
| Monaco, CM | 1 |
| Kline, AE | 1 |
| Bourgeois, JA | 1 |
| Bahadur, N | 1 |
| Minjares, S | 1 |
| Morey, CE | 1 |
| Cilo, M | 1 |
| Berry, J | 1 |
| Cusick, C | 1 |
| Walker, W | 1 |
| Seel, R | 1 |
| Gibellato, M | 1 |
| Lew, H | 1 |
| Cornis-Pop, M | 1 |
| Jena, T | 1 |
| Silver, T | 1 |
| Zhang, L | 1 |
| Plotkin, RC | 1 |
| Wang, G | 1 |
| Sandel, ME | 1 |
| Lee, S | 1 |
| Tenovuo, O | 1 |
| Khateb, A | 1 |
| Ammann, J | 1 |
| Annoni, JM | 1 |
| Diserens, K | 1 |
| Trovato, M | 1 |
| Slomine, B | 1 |
| Pidcock, F | 1 |
| Christensen, J | 1 |
| Yoo, JH | 1 |
| Valdovinos, MG | 1 |
| Williams, DC | 1 |
| Foster, M | 1 |
| Spiegel, DR | 1 |
| Fujiki, M | 1 |
| Kubo, T | 1 |
| Kamida, T | 1 |
| Sugita, K | 1 |
| Hikawa, T | 1 |
| Abe, T | 1 |
| Ishii, K | 1 |
| Kobayashi, H | 1 |
| Taverni, JP | 1 |
| Seliger, G | 1 |
| Lichtman, SW | 1 |
| Whitlock, JA | 1 |
| Whelan, FJ | 1 |
| Walker, MS | 1 |
| Schultz, SK | 1 |
| Masanic, CA | 1 |
| Bayley, MT | 1 |
| VanReekum, R | 1 |
| Simard, M | 1 |
| Blount, PJ | 1 |
| Nguyen, CD | 1 |
| McDeavitt, JT | 1 |
3 reviews available for donepezil and Brain Injuries
| Article | Year |
|---|---|
Pharmacotherapy in restorative neurology.
Topics: Brain Injuries; Donepezil; Dopamine Uptake Inhibitors; Humans; Indans; Methylphenidate; Movement; No | 2008 |
Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature.
Topics: Alzheimer Disease; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Autistic Disor | 2007 |
Clinical use of cholinomimetic agents: a review.
Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Brain Injuries; Carbamates; Clinical Trials as | 2002 |
3 trials available for donepezil and Brain Injuries
| Article | Year |
|---|---|
Cholinergic augmentation with donepezil enhances recovery in short-term memory and sustained attention after traumatic brain injury.
Topics: Adult; Attention; Brain Injuries; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Donepezi | 2004 |
Central acetylcholinesterase inhibitors in the treatment of chronic traumatic brain injury-clinical experience in 111 patients.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Cholinesterase Inhibitors; Cognition | 2005 |
Open-label study of donepezil in traumatic brain injury.
Topics: Adult; Brain Injuries; Chronic Disease; Donepezil; Humans; Indans; Male; Memory Disorders; Mental Di | 2001 |
13 other studies available for donepezil and Brain Injuries
| Article | Year |
|---|---|
Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain Injuries; Disease Mode | 2021 |
Donepezil rescues spatial learning and memory deficits following traumatic brain injury independent of its effects on neurogenesis.
Topics: Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Donepezil; Female; Ganciclovir; Inda | 2015 |
Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats.
Topics: Animals; Brain Injuries; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Ind | 2013 |
Donepezil for cognitive deficits following traumatic brain injury: a case report.
Topics: Adult; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Ma | 2002 |
The effect of Aricept in persons with persistent memory disorder following traumatic brain injury: a pilot study.
Topics: Adult; Analysis of Variance; Brain Injuries; Cholinesterase Inhibitors; Chronic Disease; Donepezil; | 2003 |
The effects of Donepezil on traumatic brain injury acute rehabilitation outcomes.
Topics: Adult; Analysis of Variance; Brain Injuries; Cognition Disorders; Donepezil; Drug Administration Sch | 2004 |
Cognition-enhancing effects of donepezil in traumatic brain injury.
Topics: Adult; Brain Injuries; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Female; | 2005 |
The efficacy of donepezil hydrochloride on memory functioning in three adolescents with severe traumatic brain injury.
Topics: Adolescent; Brain Injuries; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; | 2006 |
Use of donepezil in the treatment of cognitive impairments of moderate traumatic brain injury.
Topics: Brain Injuries; Cognition Disorders; Donepezil; Humans; Indans; Male; Middle Aged; Nootropic Agents; | 2008 |
Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury.
Topics: Animals; Brain; Brain Concussion; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; | 2008 |
Donepezil medicated memory improvement in traumatic brain injury during post acute rehabilitation.
Topics: Adult; Alzheimer Disease; Brain Injuries; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; D | 1998 |
Brain injury, cognitive impairment, and donepezil.
Topics: Alzheimer Disease; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans | 1999 |
Donepezil in the treatment of cognitive dysfunction associated with traumatic brain injury.
Topics: Adult; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; In | 2000 |