donepezil has been researched along with Brain Inflammation in 3 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil was found to decrease the LPS-induced AChE activity and oxidative stress in all the brain regions." | 1.36 | Cholinergic protection via alpha7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroinflammation. ( Agrawal, R; Nath, C; Shukla, R; Tyagi, E, 2010) |
| "Donepezil is a reversible and noncompetitive cholinesterase inhibitor." | 1.36 | Microglia signaling as a target of donepezil. ( Hwang, H; Hwang, J; Lee, HW; Suk, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meunier, J | 1 |
| Borjini, N | 1 |
| Gillis, C | 1 |
| Villard, V | 1 |
| Maurice, T | 1 |
| Tyagi, E | 1 |
| Agrawal, R | 1 |
| Nath, C | 1 |
| Shukla, R | 1 |
| Hwang, J | 1 |
| Hwang, H | 1 |
| Lee, HW | 1 |
| Suk, K | 1 |
3 other studies available for donepezil and Brain Inflammation
| Article | Year |
|---|---|
Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative.
Topics: Adenine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Age | 2015 |
Cholinergic protection via alpha7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroinflammation.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Br | 2010 |
Microglia signaling as a target of donepezil.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Line, Tumor; Cells, Cultured; Cocu | 2010 |