donepezil has been researched along with Brain Disorders in 6 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 7.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 3.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| "Pathogenesis of diabetic encephalopathy (DE) is not completely understood until now." | 1.56 | Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model. ( Li, J; Shi, S; Wang, L; Wang, WP; Wang, XL; Yin, HJ, 2020) |
| "Diabetic encephalopathy is an important complication of diabetes characterized by cognitive impairment, neurochemical and structural abnormalities." | 1.46 | Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( Aboul Naser, AF; Darwish, HA; El-Rigal, NS; Hamed, MA; Motawi, TK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, S | 1 |
| Yin, HJ | 1 |
| Li, J | 1 |
| Wang, L | 1 |
| Wang, WP | 1 |
| Wang, XL | 1 |
| Motawi, TK | 1 |
| Darwish, HA | 1 |
| Hamed, MA | 1 |
| El-Rigal, NS | 1 |
| Aboul Naser, AF | 1 |
| Tseng, WT | 1 |
| Yeh, JY | 1 |
| Lane, HY | 1 |
| Lin, CH | 1 |
| Xia, Y | 1 |
| Liu, R | 1 |
| Chen, R | 1 |
| Tian, Q | 1 |
| Zeng, K | 1 |
| Hu, J | 1 |
| Liu, X | 1 |
| Wang, Q | 1 |
| Wang, P | 1 |
| Wang, XC | 1 |
| Wang, JZ | 1 |
| Thornton, SL | 1 |
| Clark, RF | 1 |
| Song, IU | 1 |
| Cho, HJ | 1 |
| Kim, YD | 1 |
| Chung, SW | 1 |
6 other studies available for donepezil and Brain Disorders
| Article | Year |
|---|---|
Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model.
Topics: Animals; Brain Diseases; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Experimental; Diabete | 2020 |
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model.
Topics: Animals; Antioxidants; Blood Glucose; Brain Diseases; Cholinesterase Inhibitors; Diabetes Mellitus, | 2017 |
Effects of donepezil on cognition and global functioning in patients with delayed encephalopathy after carbon monoxide poisoning: A case series.
Topics: Adult; Behavioral Symptoms; Brain Diseases; Carbon Monoxide Poisoning; Cholinesterase Inhibitors; Co | 2019 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal | 2014 |
Encephalopathy from unintentional donepezil and memantine ingestion.
Topics: Brain Diseases; Child, Preschool; Donepezil; Electroencephalography; Female; Hallucinations; Humans; | 2014 |
Improvement of cognitive impairment following delayed CO encephalopathy.
Topics: Adolescent; Brain Diseases; Carbon Monoxide Poisoning; Cognition Disorders; Donepezil; Humans; Indan | 2011 |