donepezil has been researched along with Bradyarrhythmia in 11 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the paper is to systematically investigate the association between the occurrence of bradycardia in adults and the usage of donepezil using clinical data derived from the FDA Adverse Event Reporting System (FAERS) database." | 8.02 | Bradycardia Due to Donepezil in Adults: Systematic Analysis of FDA Adverse Event Reporting System. ( Bu, K; Cheng, F; Eckhoff, K; Jose, RP; Luboff, H; Morris, R; Pham, M; Rohlsen-Neal, D, 2021) |
| "Even after a single-tablet ingestion, donepezil may cause prolonged altered mental status and bradycardia in young children." | 7.80 | Prolonged altered mental status and bradycardia following pediatric donepezil ingestion. ( Balakrishnan, K; Fong, J; Garlich, FM; Howland, MA; Nelson, LS; Shah, SK, 2014) |
| "The purpose of the paper is to systematically investigate the association between the occurrence of bradycardia in adults and the usage of donepezil using clinical data derived from the FDA Adverse Event Reporting System (FAERS) database." | 4.02 | Bradycardia Due to Donepezil in Adults: Systematic Analysis of FDA Adverse Event Reporting System. ( Bu, K; Cheng, F; Eckhoff, K; Jose, RP; Luboff, H; Morris, R; Pham, M; Rohlsen-Neal, D, 2021) |
| "Patients suffering from Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies can be treated well with the cholinesterase inhibitors rivastigmine or donepezil, and because of the increasing number of these patients undergoing surgery in general anaesthesia we find it urgent to draw attention to possible complications such as severe bradycardia or third-degree heart block when propofol and remifentanil are being used." | 3.81 | [Severe bradycardia in general anaesthesia in a patient treated with cholinesterase inhibitors for dementia]. ( Ferguson, AH; Jellinge, ME, 2015) |
| "Even after a single-tablet ingestion, donepezil may cause prolonged altered mental status and bradycardia in young children." | 3.80 | Prolonged altered mental status and bradycardia following pediatric donepezil ingestion. ( Balakrishnan, K; Fong, J; Garlich, FM; Howland, MA; Nelson, LS; Shah, SK, 2014) |
| "Donepezil is a commonly used drug in older people that due to its procholinergic effects can provoke bradycardia and neurocardiogenic syncope." | 3.78 | Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study. ( Anderson, GM; Daneman, N; Fischer, HD; Gill, SS; Gruneir, A; Hutson, JR; Rochon, PA; Wang, X, 2012) |
| "Cox proportional hazards with time-dependent exposures were used to evaluate the association and examine the dose effect for donepezil and bradycardia." | 3.75 | Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare system. ( Cantor, MD; Farwell, W; Hernandez, RK; Lawler, EV, 2009) |
| "We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil)." | 3.72 | Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors. ( Barold, SS; Bordier, P; Bressolles, N; Clémenty, J; Garrigue, S; Lanusse, S, 2003) |
| " Three head-to-head trials of ChEIs in the treatment of AD have been published to date, but are limited due to their open-label design, rates of titration, and the drug dosage levels utilised." | 2.42 | The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease. ( Herrmann, N; Lanctôt, KL; Thompson, S, 2004) |
| " Their known adverse effects include bradycardia." | 1.37 | Bradycardia due to cholinesterase inhibitors: identify adverse effects and take them into account. ( , 2011) |
| " It is important to prevent dosing errors in cooperation with medical providers, patients and families." | 1.32 | [A case of acute cholinergic adverse effects induced by donepezil overdose: a follow-up of clinical course and plasma concentration of donepezil]. ( Fukuhara, Y; Kowa, H; Nakashima, K; Wada, K; Yano, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Morris, R | 1 |
| Luboff, H | 1 |
| Jose, RP | 1 |
| Eckhoff, K | 1 |
| Bu, K | 1 |
| Pham, M | 1 |
| Rohlsen-Neal, D | 1 |
| Cheng, F | 1 |
| Leikin, JB | 1 |
| Braund, V | 1 |
| DesLauris, C | 1 |
| Garlich, FM | 1 |
| Balakrishnan, K | 1 |
| Shah, SK | 1 |
| Howland, MA | 1 |
| Fong, J | 1 |
| Nelson, LS | 1 |
| Jellinge, ME | 1 |
| Ferguson, AH | 1 |
| Hernandez, RK | 1 |
| Farwell, W | 1 |
| Cantor, MD | 1 |
| Lawler, EV | 1 |
| Hutson, JR | 1 |
| Fischer, HD | 1 |
| Wang, X | 1 |
| Gruneir, A | 1 |
| Daneman, N | 1 |
| Gill, SS | 1 |
| Rochon, PA | 1 |
| Anderson, GM | 1 |
| Yano, H | 1 |
| Fukuhara, Y | 1 |
| Wada, K | 1 |
| Kowa, H | 1 |
| Nakashima, K | 1 |
| Bordier, P | 1 |
| Garrigue, S | 1 |
| Barold, SS | 1 |
| Bressolles, N | 1 |
| Lanusse, S | 1 |
| Clémenty, J | 1 |
| Thompson, S | 1 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Opie, LH | 1 |
1 review available for donepezil and Bradyarrhythmia
| Article | Year |
|---|---|
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Ganglia Diseases; Bradycardia; Central Nervous System Diseas | 2004 |
10 other studies available for donepezil and Bradyarrhythmia
| Article | Year |
|---|---|
Bradycardia Due to Donepezil in Adults: Systematic Analysis of FDA Adverse Event Reporting System.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Femal | 2021 |
Cholinergic symptoms with low serum cholinesterase from therapeutic cholinesterase inhibitor toxicity.
Topics: Aged; Bradycardia; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Humans; Indans; Lewy Body | 2014 |
Prolonged altered mental status and bradycardia following pediatric donepezil ingestion.
Topics: Accidents, Home; Bradycardia; Cholinesterase Inhibitors; Donepezil; Emergency Service, Hospital; Hum | 2014 |
[Severe bradycardia in general anaesthesia in a patient treated with cholinesterase inhibitors for dementia].
Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Bradycardia; Cholinesterase Inhibitors; Dementi | 2015 |
Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare system.
Topics: Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Cross-Sectional Studies; Dementia; Donepe | 2009 |
Bradycardia due to cholinesterase inhibitors: identify adverse effects and take them into account.
Topics: Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; P | 2011 |
Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atrioventricular Block; Bradycardia; Cardiovascular | 2012 |
[A case of acute cholinergic adverse effects induced by donepezil overdose: a follow-up of clinical course and plasma concentration of donepezil].
Topics: Aged; Alzheimer Disease; Arrhythmia, Sinus; Bradycardia; Cholinesterase Inhibitors; Donepezil; Drug | 2003 |
Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Femal | 2003 |
Donepezil for severe Alzheimer's disease.
Topics: Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Cognition; Donepezil; Heart Block; Humans | 2006 |