donepezil has been researched along with Bipolar Disorder in 17 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder." | 9.13 | A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder. ( Butters, MA; Chisholm, D; Gildengers, AG; Mulsant, BH; Reynolds, CF, 2008) |
| "These pilot data suggest the efficacy and safety of donepezil in the treatment of bipolar disorder." | 9.09 | Donepezil in treatment-resistant bipolar disorder. ( Burt, T; Demopulos, C; Sachs, GS, 1999) |
| "Acetylcholinesterase inhibitors (AceI) and memantine might prove useful in bipolar disorder (BD) given their neuroprotective and pro-cognitive effects, as highlighted by several case reports." | 8.93 | Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions. ( Correll, CU; Lu, RB; Luchini, C; Solmi, M; Stubbs, B; Veronese, N; Zaninotto, L, 2016) |
| "All bipolar disordered patients in a private practice setting treated with donepezil for memory problems were analyzed." | 7.74 | Is donepezil useful for improving cognitive dysfunction in bipolar disorder? ( Kelly, T, 2008) |
| "To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder." | 5.13 | A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder. ( Butters, MA; Chisholm, D; Gildengers, AG; Mulsant, BH; Reynolds, CF, 2008) |
| "These pilot data suggest the efficacy and safety of donepezil in the treatment of bipolar disorder." | 5.09 | Donepezil in treatment-resistant bipolar disorder. ( Burt, T; Demopulos, C; Sachs, GS, 1999) |
| "Acetylcholinesterase inhibitors (AceI) and memantine might prove useful in bipolar disorder (BD) given their neuroprotective and pro-cognitive effects, as highlighted by several case reports." | 4.93 | Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions. ( Correll, CU; Lu, RB; Luchini, C; Solmi, M; Stubbs, B; Veronese, N; Zaninotto, L, 2016) |
| "The role of lithium carbonate in the maintenance treatment of bipolar disorder is well established." | 4.82 | Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder. ( Freeman, MP; Gelenberg, AJ; Gnanadesikan, M, 2003) |
| "All bipolar disordered patients in a private practice setting treated with donepezil for memory problems were analyzed." | 3.74 | Is donepezil useful for improving cognitive dysfunction in bipolar disorder? ( Kelly, T, 2008) |
| "Donepezil was suspected to have induced the new symptoms and was discontinued." | 1.40 | Donepezil-induced mania. ( Leung, JG, 2014) |
| "Donepezil was added to their usual treatment for 8 weeks." | 1.33 | Beneficial effect of donepezil in the treatment of elderly patients with tardive movement disorders. ( Bergman, J; Brettholz, I; Dwolatzky, T; Lerner, V, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takamiya, A | 1 |
| Sawada, K | 1 |
| Hirano, J | 1 |
| Mimura, M | 1 |
| Kishimoto, T | 1 |
| Leung, JG | 1 |
| Tourian, L | 1 |
| Margolese, HC | 1 |
| Gauthier, S | 1 |
| Veronese, N | 1 |
| Solmi, M | 1 |
| Luchini, C | 1 |
| Lu, RB | 1 |
| Stubbs, B | 1 |
| Zaninotto, L | 1 |
| Correll, CU | 1 |
| Canan, F | 1 |
| Ataoglu, A | 1 |
| Collins, C | 1 |
| Copeland, B | 1 |
| Croucher, M | 1 |
| Wicklund, S | 1 |
| Wright, M | 1 |
| Gnanadesikan, M | 1 |
| Freeman, MP | 1 |
| Gelenberg, AJ | 1 |
| Bergman, J | 1 |
| Dwolatzky, T | 1 |
| Brettholz, I | 1 |
| Lerner, V | 1 |
| Eden Evins, A | 1 |
| Demopulos, C | 2 |
| Nierenberg, A | 1 |
| Culhane, MA | 1 |
| Eisner, L | 1 |
| Sachs, G | 1 |
| Kelly, T | 1 |
| Gildengers, AG | 1 |
| Butters, MA | 1 |
| Chisholm, D | 1 |
| Reynolds, CF | 1 |
| Mulsant, BH | 1 |
| Rao, V | 1 |
| Ovitt, L | 1 |
| Robbins, B | 1 |
| Benazzi, F | 3 |
| Burt, T | 1 |
| Sachs, GS | 1 |
| Rossi, E | 1 |
2 reviews available for donepezil and Bipolar Disorder
| Article | Year |
|---|---|
Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cholinesterase Inhibitors; Clinical Trials as Topic; | 2016 |
Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar | 2003 |
3 trials available for donepezil and Bipolar Disorder
| Article | Year |
|---|---|
A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Cholinesterase Inhibitors | 2006 |
A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Bipolar Disorder; Cholinesterase Inhibitors; Co | 2008 |
Donepezil in treatment-resistant bipolar disorder.
Topics: Adult; Bipolar Disorder; Cholinesterase Inhibitors; Donepezil; Drug Resistance; Female; Humans; Inda | 1999 |
12 other studies available for donepezil and Bipolar Disorder
| Article | Year |
|---|---|
Prolonged Post-Electroconvulsive Therapy Delirium Controlled With Donepezil.
Topics: Bipolar Disorder; Chronic Disease; Delirium; Donepezil; Electroconvulsive Therapy; Female; Humans; M | 2019 |
Donepezil-induced mania.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Humans; Indans; | 2014 |
Donepezil-associated mania in two patients who were using donepezil without a prescription.
Topics: Adult; Bipolar Disorder; Donepezil; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2014 |
Memantine-related psychotic symptoms in a patient with bipolar disorder.
Topics: Alzheimer Disease; Antimanic Agents; Bipolar Disorder; Donepezil; Drug Interactions; Excitatory Amin | 2010 |
Bipolar affective disorder, type II, apparently precipitated by donepezil.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Female; Humans; In | 2011 |
Donepezil-induced mania.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Mental D | 2012 |
Beneficial effect of donepezil in the treatment of elderly patients with tardive movement disorders.
Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Bipolar Disorder; Cholinesterase Inhibitors; Cog | 2005 |
Is donepezil useful for improving cognitive dysfunction in bipolar disorder?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bipolar Disorder; Cholinesterase Inhibitors; Cognition D | 2008 |
Donepezil induced hypomania.
Topics: Bipolar Disorder; Donepezil; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2008 |
Mania associated with donepezil.
Topics: Aged; Bipolar Disorder; Dementia; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Midd | 1998 |
Mania and donepezil.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Depressive Disorder, Major; Donepezil; Female; Hu | 1999 |
Mania associated with donepezil.
Topics: Aged; Alzheimer Disease; Bipolar Disorder; Donepezil; Female; Humans; Indans; Male; Nootropic Agents | 1999 |