donepezil has been researched along with Basal Ganglia Diseases in 7 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Basal Ganglia Diseases: Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3-3 mg/kg) did not induce EPS signs by itself; however, it significantly potentiated bradykinesia induction with a low dose of haloperidol (0." | 3.81 | Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice. ( Fujiwara, M; Mizuguchi, Y; Morimoto, T; Ohno, Y; Shimizu, S; Sobue, A, 2015) |
| " Three head-to-head trials of ChEIs in the treatment of AD have been published to date, but are limited due to their open-label design, rates of titration, and the drug dosage levels utilised." | 2.42 | The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease. ( Herrmann, N; Lanctôt, KL; Thompson, S, 2004) |
| "Donepezil was added to their usual treatment for 8 weeks." | 1.33 | Beneficial effect of donepezil in the treatment of elderly patients with tardive movement disorders. ( Bergman, J; Brettholz, I; Dwolatzky, T; Lerner, V, 2005) |
| "The cholinergic hypothesis of Alzheimer's disease is the basis of a new class of drugs: acetylcholinesterase inhibitors." | 1.31 | [Extra-pyramidal syndrome induced by donepezil]. ( Alt, M; Carcenac, D; Demuynck-Roegel, C; Kiesmann, M; Kuntzmann, F; Martin-Hunyadi, C, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimizu, S | 1 |
| Mizuguchi, Y | 1 |
| Sobue, A | 1 |
| Fujiwara, M | 1 |
| Morimoto, T | 1 |
| Ohno, Y | 1 |
| Liu, HC | 1 |
| Lin, SK | 1 |
| Sung, SM | 1 |
| Thompson, S | 1 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Simard, M | 1 |
| van Reekum, R | 1 |
| Bergman, J | 1 |
| Dwolatzky, T | 1 |
| Brettholz, I | 1 |
| Lerner, V | 1 |
| Magnuson, TM | 1 |
| Keller, BK | 1 |
| Burke, WJ | 1 |
| Carcenac, D | 1 |
| Martin-Hunyadi, C | 1 |
| Kiesmann, M | 1 |
| Demuynck-Roegel, C | 1 |
| Alt, M | 1 |
| Kuntzmann, F | 1 |
2 reviews available for donepezil and Basal Ganglia Diseases
| Article | Year |
|---|---|
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Ganglia Diseases; Bradycardia; Central Nervous System Diseas | 2004 |
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies.
Topics: Aged; Basal Ganglia Diseases; Behavior; Cholinesterase Inhibitors; Clinical Trials as Topic; Cogniti | 2004 |
5 other studies available for donepezil and Basal Ganglia Diseases
| Article | Year |
|---|---|
Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Cholinesterase Inhibitors; | 2015 |
Extrapyramidal side-effect due to drug combination of risperidone and donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Donepezil; | 2002 |
Beneficial effect of donepezil in the treatment of elderly patients with tardive movement disorders.
Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Bipolar Disorder; Cholinesterase Inhibitors; Cog | 2005 |
Extrapyramidal side effects in a patient treated with risperidone plus donepezil.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Cholinesterase Inhibitors; Co | 1998 |
[Extra-pyramidal syndrome induced by donepezil].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Basal Ganglia Diseases; Cholinesterase Inhibitors; Donep | 2000 |