donepezil has been researched along with Autistic Disorder in 8 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The safety and efficacy of a novel combination treatment of AChE inhibitors and choline supplement was initiated and evaluated in children and adolescents with autism spectrum disorder (ASD)." | 9.30 | Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment. ( Ben-Hur, R; Gabis, LV; Jokel, A; Shalom, DB; Shefer, S, 2019) |
| ") on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i." | 7.88 | The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. ( Al-Houqani, M; Azimullah, S; Eissa, N; Jalal, FY; Jayaprakash, P; Kieć-Kononowicz, K; Ojha, SK; Sadek, B; Łażewska, D, 2018) |
| "In light of the recently reported neuropathologic and neurochemical abnormalities of the cholinergic pathways in autism, donepezil, a cholinesterase inhibitor, is a potentially useful agent in the treatment of cognitive and behavioral symptoms observed in this disorder." | 7.71 | A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder. ( Handen, BL; Hardan, AY, 2002) |
| "Donepezil can increase the amount of time that children with an ASD spend in the REM sleep state." | 6.76 | An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders. ( Buckley, AW; Buckley, J; Jennison, K; Rodriguez, AJ; Sassower, K; Sato, S; Swedo, S; Thurm, A; Wingert, K, 2011) |
| "The safety and efficacy of a novel combination treatment of AChE inhibitors and choline supplement was initiated and evaluated in children and adolescents with autism spectrum disorder (ASD)." | 5.30 | Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment. ( Ben-Hur, R; Gabis, LV; Jokel, A; Shalom, DB; Shefer, S, 2019) |
| "This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia." | 4.84 | Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature. ( Valdovinos, MG; Williams, DC; Yoo, JH, 2007) |
| ") on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i." | 3.88 | The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. ( Al-Houqani, M; Azimullah, S; Eissa, N; Jalal, FY; Jayaprakash, P; Kieć-Kononowicz, K; Ojha, SK; Sadek, B; Łażewska, D, 2018) |
| "In light of the recently reported neuropathologic and neurochemical abnormalities of the cholinergic pathways in autism, donepezil, a cholinesterase inhibitor, is a potentially useful agent in the treatment of cognitive and behavioral symptoms observed in this disorder." | 3.71 | A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder. ( Handen, BL; Hardan, AY, 2002) |
| "Donepezil can increase the amount of time that children with an ASD spend in the REM sleep state." | 2.76 | An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders. ( Buckley, AW; Buckley, J; Jennison, K; Rodriguez, AJ; Sassower, K; Sato, S; Swedo, S; Thurm, A; Wingert, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eissa, N | 1 |
| Jayaprakash, P | 1 |
| Azimullah, S | 1 |
| Ojha, SK | 1 |
| Al-Houqani, M | 1 |
| Jalal, FY | 1 |
| Łażewska, D | 1 |
| Kieć-Kononowicz, K | 1 |
| Sadek, B | 1 |
| Gabis, LV | 1 |
| Ben-Hur, R | 1 |
| Shefer, S | 1 |
| Jokel, A | 1 |
| Shalom, DB | 1 |
| Karvat, G | 1 |
| Kimchi, T | 1 |
| Kim, JW | 1 |
| Seung, H | 1 |
| Kwon, KJ | 1 |
| Ko, MJ | 1 |
| Lee, EJ | 1 |
| Oh, HA | 1 |
| Choi, CS | 1 |
| Kim, KC | 1 |
| Gonzales, EL | 1 |
| You, JS | 1 |
| Choi, DH | 1 |
| Lee, J | 1 |
| Han, SH | 1 |
| Yang, SM | 1 |
| Cheong, JH | 1 |
| Shin, CY | 1 |
| Bahn, GH | 1 |
| Handen, BL | 2 |
| Johnson, CR | 1 |
| McAuliffe-Bellin, S | 1 |
| Murray, PJ | 1 |
| Hardan, AY | 2 |
| Buckley, AW | 1 |
| Sassower, K | 1 |
| Rodriguez, AJ | 1 |
| Jennison, K | 1 |
| Wingert, K | 1 |
| Buckley, J | 1 |
| Thurm, A | 1 |
| Sato, S | 1 |
| Swedo, S | 1 |
| Yoo, JH | 1 |
| Valdovinos, MG | 1 |
| Williams, DC | 1 |
1 review available for donepezil and Autistic Disorder
| Article | Year |
|---|---|
Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature.
Topics: Alzheimer Disease; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Autistic Disor | 2007 |
3 trials available for donepezil and Autistic Disorder
| Article | Year |
|---|---|
Improvement of Language in Children with Autism with Combined Donepezil and Choline Treatment.
Topics: Adolescent; Autistic Disorder; Child; Choline; Donepezil; Drug Therapy, Combination; Female; Gastroi | 2019 |
Safety and efficacy of donepezil in children and adolescents with autism: neuropsychological measures.
Topics: Adolescent; Autistic Disorder; Child; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationsh | 2011 |
An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders.
Topics: Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Developmental Di | 2011 |
4 other studies available for donepezil and Autistic Disorder
| Article | Year |
|---|---|
The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Brain; Choice Behavior; Cytokines; Disease Mo | 2018 |
Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism.
Topics: Acetylcholine; Animals; Autistic Disorder; Caudate Nucleus; Cholinesterase Inhibitors; Cognition Dis | 2014 |
Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism.
Topics: Acetylcholinesterase; Animals; Autistic Disorder; Behavior, Animal; Blotting, Western; Cells, Cultur | 2014 |
A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder.
Topics: Adolescent; Adult; Autistic Disorder; Child; Donepezil; Female; Humans; Indans; Male; Pilot Projects | 2002 |