Page last updated: 2024-10-26

donepezil and Aura

donepezil has been researched along with Aura in 3 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Research Excerpts

ExcerptRelevanceReference
"To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints."9.12A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy. ( Choi, H; Hamberger, MJ; Hirsch, LJ; Palmese, CA; Scarmeas, N; Weintraub, D, 2007)
"To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints."5.12A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy. ( Choi, H; Hamberger, MJ; Hirsch, LJ; Palmese, CA; Scarmeas, N; Weintraub, D, 2007)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Jin, N1
Ziyatdinova, S1
Gureviciene, I1
Tanila, H1
Matias, M1
Silvestre, S1
Falcao, A1
Alves, G1
Hamberger, MJ1
Palmese, CA1
Scarmeas, N1
Weintraub, D1
Choi, H1
Hirsch, LJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Does Memantine Improve Verbal Memory Task Performance in Subjects With Localization-related Epilepsy and Memory Dysfunction? A Randomized, Double-Blind, Placebo-Controlled Trial[NCT01054599]29 participants (Actual)Interventional2009-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

A Secondary Analysis Will Examine the Possible Sustained Benefit of Continued Memantine Use.

SRT-CLTR (range 0-72; higher scores indicate better memory), and 7-24 Spatial Memory Test (range 0-35; scores are summed across the 5 learning trials, with higher scores indicating better memory) scores will be assessed across the first (baseline) and third (post-open label memantine) testing sessions. These measures are considered to be scores on a scale, rather than standard units. The hypothesis was that subjects randomized to memantine would demonstrate sustained improvement from baseline, while the placebo group would demonstrate improvements after taking open label memantine (compared to baseline). (NCT01054599)
Timeframe: 26 weeks

,
Interventionscores on a scale (Mean)
SRT CLTR BaselineSRT CLTR Post-Open Label7-24 Total Learning Baseline7-24 Total Learning Post-Open Label
Memantine32.6740.3330.3331.67
Sugar Pill22.7140.2928.1432.43

The Change Scores in Memory Measures From Baseline to Post-treatment/Placebo Will be Compared Between the Memantine Treatment and Placebo Groups.

Change scores from pre- to post-treatment/placebo were calculated for the primary outcome measures, the Selective Reminding Test Continuous Long-Term Retrieval (range 0-72; higher scores indicate better memory) and 7-24 Spatial Recall Test Total Learning (range 0-35; total correct across 5 learning trials are summed, with higher scores indicating better memory) scores. These measures are scores on a scale, rather than representing standard units. (NCT01054599)
Timeframe: 13 weeks

,
Interventionscores on a scale (Mean)
7-24 Spatial Recall Tests Learning Change ScoreSRT Continuous Long-Term Retrieval Change Score
Memantine1.004.38
Sugar Pill1.788.11

Reviews

1 review available for donepezil and Aura

ArticleYear
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:6

    Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid;

2017

Trials

1 trial available for donepezil and Aura

ArticleYear
A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Cholinesterase Inhibitors; Cognition Disorders; Cross-Over Studies; Donepezil; Dose-Response Relatio

2007

Other Studies

1 other study available for donepezil and Aura

ArticleYear
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
    Scientific reports, 2020, 07-16, Volume: 10, Issue:1

    Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis

2020