donepezil has been researched along with Atrioventricular Block in 3 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Atrioventricular Block: Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimer's disease (AD), but their cholinergic effects could generate adverse side effects in the cardiovascular system." | 5.35 | Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes. ( Hiramatsu, Y; Koga, S; Tanaka, A, 2009) |
| "Donepezil is a commonly used drug in older people that due to its procholinergic effects can provoke bradycardia and neurocardiogenic syncope." | 3.78 | Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study. ( Anderson, GM; Daneman, N; Fischer, HD; Gill, SS; Gruneir, A; Hutson, JR; Rochon, PA; Wang, X, 2012) |
| "Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimer's disease (AD), but their cholinergic effects could generate adverse side effects in the cardiovascular system." | 1.35 | Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes. ( Hiramatsu, Y; Koga, S; Tanaka, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kho, J | 1 |
| Ioannou, A | 1 |
| Mandal, AKJ | 1 |
| Missouris, CG | 1 |
| Tanaka, A | 1 |
| Koga, S | 1 |
| Hiramatsu, Y | 1 |
| Hutson, JR | 1 |
| Fischer, HD | 1 |
| Wang, X | 1 |
| Gruneir, A | 1 |
| Daneman, N | 1 |
| Gill, SS | 1 |
| Rochon, PA | 1 |
| Anderson, GM | 1 |
3 other studies available for donepezil and Atrioventricular Block
| Article | Year |
|---|---|
Donepezil induces ventricular arrhythmias by delayed repolarisation.
Topics: Alzheimer Disease; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Cholinesterase Inhibitors; | 2021 |
Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes.
Topics: Aged, 80 and over; Atrioventricular Block; Cholinesterase Inhibitors; Donepezil; Female; Humans; Ind | 2009 |
Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atrioventricular Block; Bradycardia; Cardiovascular | 2012 |