donepezil has been researched along with Arrhythmias, Cardiac in 9 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear." | 6.77 | Cardiac safety of donepezil in elderly patients with Alzheimer disease. ( Aydemir, E; Bozoglu, E; Isik, AT; Yay, A; Yildiz, GB, 2012) |
| "Donepezil, galantamine, and rivastigmine are the three acetylcholinesterase inhibitors (AChEIs), out of a total of only four medications prescribed in the treatment of Alzheimer's Disease (AD) and related dementias." | 5.05 | Comparative risk of cardiac arrhythmias associated with acetylcholinesterase inhibitors used in treatment of dementias - A narrative review. ( Alsabbagh, MW; Huang, Y, 2020) |
| " We therefore examined the electrophysiologic profile of donepezil, rivastigmine, and galantamine in a sensitive whole-heart model of proarrhythmia." | 3.96 | Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model. ( Coenen, A; Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Leitz, P; Niehues, P, 2020) |
| "Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear." | 2.77 | Cardiac safety of donepezil in elderly patients with Alzheimer disease. ( Aydemir, E; Bozoglu, E; Isik, AT; Yay, A; Yildiz, GB, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Mandal, AKJ | 2 |
| Missouris, CG | 2 |
| Atamanalp, SS | 1 |
| Huang, Y | 1 |
| Alsabbagh, MW | 1 |
| Kho, J | 1 |
| Ioannou, A | 1 |
| Pourmand, A | 1 |
| Shay, C | 1 |
| Redha, W | 1 |
| Aalam, A | 1 |
| Mazer-Amirshahi, M | 1 |
| Malik, BH | 1 |
| Ellermann, C | 1 |
| Coenen, A | 1 |
| Niehues, P | 1 |
| Leitz, P | 1 |
| Kochhäuser, S | 1 |
| Dechering, DG | 1 |
| Fehr, M | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Celik, IE | 1 |
| Acar, B | 1 |
| Çay, S | 1 |
| Isik, AT | 1 |
| Yildiz, GB | 1 |
| Bozoglu, E | 1 |
| Yay, A | 1 |
| Aydemir, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 6 Months, Prospective, Open-label, Observational, Non-interventional Clinical Trial to Examine the Efficacy and Safety of Donepezil (Dementis®) Administration in Patients With Dementia.[NCT01772095] | 389 participants (Actual) | Observational | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for donepezil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Comparative risk of cardiac arrhythmias associated with acetylcholinesterase inhibitors used in treatment of dementias - A narrative review.
Topics: Alzheimer Disease; Animals; Arrhythmias, Cardiac; Cholinesterase Inhibitors; Dementia; Donepezil; Ga | 2020 |
1 trial available for donepezil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Cardiac safety of donepezil in elderly patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Blood Pressure; Cholinesterase Inh | 2012 |
7 other studies available for donepezil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Authors' reply to comment on "Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil".
Topics: Arrhythmias, Cardiac; Donepezil; Humans; Intestinal Volvulus; Tachycardia, Ventricular | 2020 |
Comment on "Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil".
Topics: Arrhythmias, Cardiac; Donepezil; Humans; Intestinal Volvulus; Tachycardia, Ventricular | 2020 |
Donepezil induces ventricular arrhythmias by delayed repolarisation.
Topics: Alzheimer Disease; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Cholinesterase Inhibitors; | 2021 |
Cholinergic symptoms and QTc prolongation following donepezil overdose.
Topics: Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Cholinesterase Inhibitors; Donepezil; Dr | 2017 |
Donepezil - QT prolongation and torsades de pointes.
Topics: Accidental Falls; Arrhythmias, Cardiac; Donepezil; Humans; Long QT Syndrome; Torsades de Pointes | 2019 |
Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiotoxicity; Cholinesterase Inhibitors; Donepez | 2020 |
An unusual cardiovascular adverse effect of donepezil.
Topics: Arrhythmias, Cardiac; Cholinesterase Inhibitors; Dementia; Donepezil; Electrocardiography; Female; H | 2015 |