donepezil has been researched along with Arrhythmia in 9 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear." | 6.77 | Cardiac safety of donepezil in elderly patients with Alzheimer disease. ( Aydemir, E; Bozoglu, E; Isik, AT; Yay, A; Yildiz, GB, 2012) |
| "Donepezil, galantamine, and rivastigmine are the three acetylcholinesterase inhibitors (AChEIs), out of a total of only four medications prescribed in the treatment of Alzheimer's Disease (AD) and related dementias." | 5.05 | Comparative risk of cardiac arrhythmias associated with acetylcholinesterase inhibitors used in treatment of dementias - A narrative review. ( Alsabbagh, MW; Huang, Y, 2020) |
| " We therefore examined the electrophysiologic profile of donepezil, rivastigmine, and galantamine in a sensitive whole-heart model of proarrhythmia." | 3.96 | Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model. ( Coenen, A; Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Leitz, P; Niehues, P, 2020) |
| "Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear." | 2.77 | Cardiac safety of donepezil in elderly patients with Alzheimer disease. ( Aydemir, E; Bozoglu, E; Isik, AT; Yay, A; Yildiz, GB, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Mandal, AKJ | 2 |
| Missouris, CG | 2 |
| Atamanalp, SS | 1 |
| Huang, Y | 1 |
| Alsabbagh, MW | 1 |
| Kho, J | 1 |
| Ioannou, A | 1 |
| Pourmand, A | 1 |
| Shay, C | 1 |
| Redha, W | 1 |
| Aalam, A | 1 |
| Mazer-Amirshahi, M | 1 |
| Malik, BH | 1 |
| Ellermann, C | 1 |
| Coenen, A | 1 |
| Niehues, P | 1 |
| Leitz, P | 1 |
| Kochhäuser, S | 1 |
| Dechering, DG | 1 |
| Fehr, M | 1 |
| Eckardt, L | 1 |
| Frommeyer, G | 1 |
| Celik, IE | 1 |
| Acar, B | 1 |
| Çay, S | 1 |
| Isik, AT | 1 |
| Yildiz, GB | 1 |
| Bozoglu, E | 1 |
| Yay, A | 1 |
| Aydemir, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 6 Months, Prospective, Open-label, Observational, Non-interventional Clinical Trial to Examine the Efficacy and Safety of Donepezil (Dementis®) Administration in Patients With Dementia.[NCT01772095] | 389 participants (Actual) | Observational | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for donepezil and Arrhythmia
| Article | Year |
|---|---|
Comparative risk of cardiac arrhythmias associated with acetylcholinesterase inhibitors used in treatment of dementias - A narrative review.
Topics: Alzheimer Disease; Animals; Arrhythmias, Cardiac; Cholinesterase Inhibitors; Dementia; Donepezil; Ga | 2020 |
1 trial available for donepezil and Arrhythmia
| Article | Year |
|---|---|
Cardiac safety of donepezil in elderly patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Blood Pressure; Cholinesterase Inh | 2012 |
7 other studies available for donepezil and Arrhythmia
| Article | Year |
|---|---|
Authors' reply to comment on "Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil".
Topics: Arrhythmias, Cardiac; Donepezil; Humans; Intestinal Volvulus; Tachycardia, Ventricular | 2020 |
Comment on "Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil".
Topics: Arrhythmias, Cardiac; Donepezil; Humans; Intestinal Volvulus; Tachycardia, Ventricular | 2020 |
Donepezil induces ventricular arrhythmias by delayed repolarisation.
Topics: Alzheimer Disease; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Cholinesterase Inhibitors; | 2021 |
Cholinergic symptoms and QTc prolongation following donepezil overdose.
Topics: Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Cholinesterase Inhibitors; Donepezil; Dr | 2017 |
Donepezil - QT prolongation and torsades de pointes.
Topics: Accidental Falls; Arrhythmias, Cardiac; Donepezil; Humans; Long QT Syndrome; Torsades de Pointes | 2019 |
Proarrhythmic Effect of Acetylcholine-Esterase Inhibitors Used in the Treatment of Alzheimer's Disease: Benefit of Rivastigmine in an Experimental Whole-Heart Model.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiotoxicity; Cholinesterase Inhibitors; Donepez | 2020 |
An unusual cardiovascular adverse effect of donepezil.
Topics: Arrhythmias, Cardiac; Cholinesterase Inhibitors; Dementia; Donepezil; Electrocardiography; Female; H | 2015 |