donepezil has been researched along with Aphasia in 6 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Aphasia: A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone and combined with intensive language action therapy (ILAT) for the treatment of apathy and depression in ten people with chronic post-stroke aphasia." | 9.69 | Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study. ( Berthier, ML; Dávila, G; Edelkraut, L; Jorge, RE; López-Barroso, D; López-González, FJ; Mohr, B; Pulvermüller, F; Starkstein, SE; Torres-Prioris, MJ, 2023) |
| "We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia." | 9.12 | A randomized, placebo-controlled study of donepezil in poststroke aphasia. ( Berthier, ML; Fernández, I; Green, C; Higueras, C; Hinojosa, J; Martín, MC, 2006) |
| "This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone and combined with intensive language action therapy (ILAT) for the treatment of apathy and depression in ten people with chronic post-stroke aphasia." | 5.69 | Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study. ( Berthier, ML; Dávila, G; Edelkraut, L; Jorge, RE; López-Barroso, D; López-González, FJ; Mohr, B; Pulvermüller, F; Starkstein, SE; Torres-Prioris, MJ, 2023) |
| "We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia." | 5.12 | A randomized, placebo-controlled study of donepezil in poststroke aphasia. ( Berthier, ML; Fernández, I; Green, C; Higueras, C; Hinojosa, J; Martín, MC, 2006) |
| "Pharmacotherapy of aphasia had been discussed for the last twenty years with first bromocriptine and amphetamine and then serotoninergic, GABAergic and cholinergic agents." | 4.84 | Pharmacotherapy of aphasia: myth or reality? ( de Boissezon, X; de Boysson, C; Démonet, JF; Peran, P, 2007) |
| "Donepezil has a significant effect in improving the ability of auditory comprehension, naming, repetition and oral expression." | 2.58 | The Efficacy and Safety of Pharmacological Treatments for Post-stroke Aphasia. ( Du, G; Fu, Q; Huang, L; Shu, B; Zhang, D; Zhang, X, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Swenson, TL | 1 |
| Roehmer, C | 1 |
| Tran, R | 1 |
| Plummer, C | 1 |
| Berthier, ML | 4 |
| Edelkraut, L | 2 |
| López-González, FJ | 2 |
| López-Barroso, D | 2 |
| Mohr, B | 2 |
| Pulvermüller, F | 2 |
| Starkstein, SE | 2 |
| Jorge, RE | 2 |
| Torres-Prioris, MJ | 2 |
| Dávila, G | 2 |
| Zhang, X | 1 |
| Shu, B | 1 |
| Zhang, D | 1 |
| Huang, L | 1 |
| Fu, Q | 1 |
| Du, G | 1 |
| Hinojosa, J | 2 |
| Martín, Mdel C | 1 |
| Fernández, I | 2 |
| de Boissezon, X | 1 |
| Peran, P | 1 |
| de Boysson, C | 1 |
| Démonet, JF | 1 |
| Green, C | 1 |
| Higueras, C | 1 |
| Martín, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Combining Donepezil, Intensive Language Rehabilitation and Transcranial Direct Current Stimulation on Language Recovery and Brain Reorganization in Chronic Post-stroke Aphasia[NCT04134416] | Phase 3 | 20 participants (Actual) | Interventional | 2019-01-08 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for donepezil and Aphasia
| Article | Year |
|---|---|
The Efficacy and Safety of Pharmacological Treatments for Post-stroke Aphasia.
Topics: Aphasia; Databases, Factual; Donepezil; Humans; Memantine; Nootropic Agents; Stroke | 2018 |
Pharmacotherapy of aphasia: myth or reality?
Topics: Amphetamine; Aphasia; Bromocriptine; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; | 2007 |
2 trials available for donepezil and Aphasia
| Article | Year |
|---|---|
Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study.
Topics: Apathy; Aphasia; Depression; Donepezil; Feasibility Studies; Humans; Language; Language Therapy; Tre | 2023 |
Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study.
Topics: Apathy; Aphasia; Depression; Donepezil; Feasibility Studies; Humans; Language; Language Therapy; Tre | 2023 |
Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study.
Topics: Apathy; Aphasia; Depression; Donepezil; Feasibility Studies; Humans; Language; Language Therapy; Tre | 2023 |
Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study.
Topics: Apathy; Aphasia; Depression; Donepezil; Feasibility Studies; Humans; Language; Language Therapy; Tre | 2023 |
A randomized, placebo-controlled study of donepezil in poststroke aphasia.
Topics: Acetylcholine; Adult; Aphasia; Brain; Cerebrovascular Circulation; Donepezil; Double-Blind Method; F | 2006 |
2 other studies available for donepezil and Aphasia
| Article | Year |
|---|---|
Donepezil for Aphasia After Severe Traumatic Brain Injury: A Clinical Vignette.
Topics: Aphasia; Brain Injuries, Traumatic; Donepezil; Humans | 2022 |
Open-label study of donepezil in chronic poststroke aphasia.
Topics: Adult; Aged; Aphasia; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Female; Humans; Indans; | 2003 |