donepezil has been researched along with Anxiety in 6 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we characterize the effects of 24-h donepezil administration on anxiety-like behavioral and endocrine responses in adult zebrafish." | 7.96 | An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish. ( Bueno, BW; de Abreu, MS; Demin, KA; Genario, R; Giacomini, AC; Kalueff, AV; Kolesnikova, TO; Marcon, L; Scolari, N, 2020) |
| ") on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i." | 7.88 | The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. ( Al-Houqani, M; Azimullah, S; Eissa, N; Jalal, FY; Jayaprakash, P; Kieć-Kononowicz, K; Ojha, SK; Sadek, B; Łażewska, D, 2018) |
| " Mood disorders (depression, anxiety and apathy) were significantly decreased in subjects treated with donepezil and choline alphoscerate, while their severity and frequency was increased in the other group." | 5.24 | The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial. ( Amenta, F; Carotenuto, A; Fasanaro, AM; Manzo, V; Rea, R; Ricci, G; Traini, E, 2017) |
| "Donepezil significantly increased ratings of vigour and anxiety symptoms (medium effect sizes)." | 5.17 | Acute mood effect of donepezil in young, healthy volunteers. ( Galduróz, JC; Gouveia, JR; Pompeia, S, 2013) |
| "Here, we characterize the effects of 24-h donepezil administration on anxiety-like behavioral and endocrine responses in adult zebrafish." | 3.96 | An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish. ( Bueno, BW; de Abreu, MS; Demin, KA; Genario, R; Giacomini, AC; Kalueff, AV; Kolesnikova, TO; Marcon, L; Scolari, N, 2020) |
| ") on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i." | 3.88 | The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. ( Al-Houqani, M; Azimullah, S; Eissa, N; Jalal, FY; Jayaprakash, P; Kieć-Kononowicz, K; Ojha, SK; Sadek, B; Łażewska, D, 2018) |
| "Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD)." | 1.46 | Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. ( Cui, L; Hattori, S; Hayashi, T; Ikejima, T; Liu, B; Liu, W; Song, X; Tashiro, SI; Ushiki-Kaku, Y; Xu, F; Zhou, B, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Giacomini, AC | 1 |
| Bueno, BW | 1 |
| Marcon, L | 1 |
| Scolari, N | 1 |
| Genario, R | 1 |
| Demin, KA | 1 |
| Kolesnikova, TO | 1 |
| Kalueff, AV | 1 |
| de Abreu, MS | 1 |
| Song, X | 1 |
| Liu, B | 1 |
| Cui, L | 1 |
| Zhou, B | 1 |
| Liu, W | 1 |
| Xu, F | 1 |
| Hayashi, T | 1 |
| Hattori, S | 1 |
| Ushiki-Kaku, Y | 1 |
| Tashiro, SI | 1 |
| Ikejima, T | 1 |
| Eissa, N | 1 |
| Jayaprakash, P | 1 |
| Azimullah, S | 1 |
| Ojha, SK | 1 |
| Al-Houqani, M | 1 |
| Jalal, FY | 1 |
| Łażewska, D | 1 |
| Kieć-Kononowicz, K | 1 |
| Sadek, B | 1 |
| Pompeia, S | 1 |
| Gouveia, JR | 1 |
| Galduróz, JC | 1 |
| Carotenuto, A | 1 |
| Rea, R | 1 |
| Traini, E | 1 |
| Fasanaro, AM | 1 |
| Ricci, G | 1 |
| Manzo, V | 1 |
| Amenta, F | 1 |
| Gauthier, S | 1 |
| Feldman, H | 1 |
| Hecker, J | 1 |
| Vellas, B | 1 |
| Ames, D | 1 |
| Subbiah, P | 1 |
| Whalen, E | 1 |
| Emir, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 6 Months, Prospective, Open-label, Observational, Non-interventional Clinical Trial to Examine the Efficacy and Safety of Donepezil (Dementis®) Administration in Patients With Dementia.[NCT01772095] | 389 participants (Actual) | Observational | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for donepezil and Anxiety
| Article | Year |
|---|---|
Acute mood effect of donepezil in young, healthy volunteers.
Topics: Adult; Affect; Anxiety; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Cross-Over Stu | 2013 |
The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.
Topics: Aged; Alzheimer Disease; Anxiety; Apathy; Caregivers; Depression; Donepezil; Double-Blind Method; Fe | 2017 |
Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anxiety; Arousal; Depression; Donepezil; Double-Blind Method; Female; Human | 2002 |
3 other studies available for donepezil and Anxiety
| Article | Year |
|---|---|
An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Fe | 2020 |
Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Autophagy; Brain-Derived Neurotrophic Fa | 2017 |
The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Brain; Choice Behavior; Cytokines; Disease Mo | 2018 |