donepezil has been researched along with Alloxan Diabetes in 9 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alzheimer's disease is the most common cause of dementia in the elderly population." | 1.72 | Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. ( Ali, RH; Ali, SK, 2022) |
| "Metformin/donepezil were used to treat streptozotocin (STZ)-induced diabetic mice models." | 1.62 | The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments. ( Hou, Y; Li, FZ, 2021) |
| "Pathogenesis of diabetic encephalopathy (DE) is not completely understood until now." | 1.56 | Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model. ( Li, J; Shi, S; Wang, L; Wang, WP; Wang, XL; Yin, HJ, 2020) |
| "Donepezil (DNPZ) has shown neuroprotective effect in many disorders." | 1.56 | Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl ( Abogresha, NM; Ahmed, E; Alattar, A; Alshaman, R; El-Kherbetawy, MK; Elaskary, AA; Elsherbiny, NM; Hashish, AA; Rashed, LA; Zaitone, SA, 2020) |
| "Donepezil can activate AMPK and exerts neuroprotective effects." | 1.51 | Donepezil improves neuropathy through activation of AMPK signalling pathway in streptozotocin-induced diabetic mice. ( Ahmed, AAM; Atef, MM; El-Sayed, NM; Mostafa, YM, 2019) |
| "Diabetic encephalopathy is an important complication of diabetes characterized by cognitive impairment, neurochemical and structural abnormalities." | 1.46 | Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( Aboul Naser, AF; Darwish, HA; El-Rigal, NS; Hamed, MA; Motawi, TK, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, Y | 1 |
| Li, FZ | 1 |
| Ali, SK | 1 |
| Ali, RH | 1 |
| Shi, S | 1 |
| Yin, HJ | 1 |
| Li, J | 1 |
| Wang, L | 1 |
| Wang, WP | 1 |
| Wang, XL | 1 |
| Gomaa, AA | 1 |
| Makboul, RM | 1 |
| El-Mokhtar, MA | 1 |
| Abdel-Rahman, EA | 1 |
| Ahmed, EA | 1 |
| Nicola, MA | 1 |
| Zaitone, SA | 1 |
| Alshaman, R | 1 |
| Alattar, A | 1 |
| Elsherbiny, NM | 1 |
| Abogresha, NM | 1 |
| El-Kherbetawy, MK | 1 |
| Elaskary, AA | 1 |
| Hashish, AA | 1 |
| Rashed, LA | 1 |
| Ahmed, E | 1 |
| Motawi, TK | 1 |
| Darwish, HA | 1 |
| Hamed, MA | 1 |
| El-Rigal, NS | 1 |
| Aboul Naser, AF | 1 |
| Atef, MM | 1 |
| El-Sayed, NM | 1 |
| Ahmed, AAM | 1 |
| Mostafa, YM | 1 |
| Bhutada, P | 2 |
| Mundhada, Y | 1 |
| Bansod, K | 1 |
| Tawari, S | 1 |
| Patil, S | 1 |
| Dixit, P | 1 |
| Umathe, S | 1 |
| Mundhada, D | 1 |
| Rahigude, A | 1 |
| Kaulaskar, S | 1 |
| Aswar, M | 1 |
| Otari, K | 1 |
9 other studies available for donepezil and Alloxan Diabetes
| Article | Year |
|---|---|
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Topics: Animals; Apoptosis; Brain; Cholinesterase Inhibitors; Computational Biology; Diabetes Mellitus, Expe | 2021 |
Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2022 |
Studies of pathology and pharmacology of diabetic encephalopathy with KK-Ay mouse model.
Topics: Animals; Brain Diseases; Brain-Derived Neurotrophic Factor; Diabetes Mellitus, Experimental; Diabete | 2020 |
Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats.
Topics: Alzheimer Disease; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Donepezil; H | 2021 |
Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl
Topics: Animals; Cholinesterase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Donepezil | 2020 |
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model.
Topics: Animals; Antioxidants; Blood Glucose; Brain Diseases; Cholinesterase Inhibitors; Diabetes Mellitus, | 2017 |
Donepezil improves neuropathy through activation of AMPK signalling pathway in streptozotocin-induced diabetic mice.
Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cell | 2019 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Ber | 2011 |
Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Cholinesterase Inhibitors; Cholinesterases; Diabe | 2012 |