donepezil has been researched along with Absence Seizure in 11 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil pre-treatment by itself induced only a comparatively weaker inhibition of acetylcholinesterase staining and infrequent yawning." | 5.36 | Donepezil inhibits diisopropylfluorophosphate-induced seizures and up-regulation of synaptotagmin 4 mRNA. ( Pregelj, P; Saghafi, MM; Zivin, M, 2010) |
| "However, one study subject had epileptic seizures after IVIg." | 2.84 | Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease. ( Allsop, D; Ataka, S; Ishii, R; Kasai, T; Kondo, M; Mizuno, T; Mori, H; Nakagawa, M; Shimada, H; Tanaka, A; Taylor, M; Tokuda, T; Tomiyama, T, 2017) |
| "Pretreatment with donepezil aggravated neuronal death, oxidative injury, and microglia activation." | 1.46 | Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kho, AR; Lee, SH; Lee, SY; Song, HK; Suh, SW, 2017) |
| "Donepezil pre-treatment by itself induced only a comparatively weaker inhibition of acetylcholinesterase staining and infrequent yawning." | 1.36 | Donepezil inhibits diisopropylfluorophosphate-induced seizures and up-regulation of synaptotagmin 4 mRNA. ( Pregelj, P; Saghafi, MM; Zivin, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, JC | 1 |
| Thelin, JT | 1 |
| Escayg, A | 1 |
| Kasai, T | 1 |
| Kondo, M | 1 |
| Ishii, R | 1 |
| Tanaka, A | 1 |
| Ataka, S | 1 |
| Shimada, H | 1 |
| Tomiyama, T | 1 |
| Mori, H | 1 |
| Taylor, M | 1 |
| Allsop, D | 1 |
| Nakagawa, M | 1 |
| Mizuno, T | 1 |
| Tokuda, T | 1 |
| Davoren, JE | 1 |
| Garnsey, M | 1 |
| Pettersen, B | 1 |
| Brodney, MA | 1 |
| Edgerton, JR | 1 |
| Fortin, JP | 1 |
| Grimwood, S | 1 |
| Harris, AR | 1 |
| Jenkinson, S | 1 |
| Kenakin, T | 1 |
| Lazzaro, JT | 1 |
| Lee, CW | 1 |
| Lotarski, SM | 1 |
| Nottebaum, L | 1 |
| O'Neil, SV | 1 |
| Popiolek, M | 1 |
| Ramsey, S | 1 |
| Steyn, SJ | 1 |
| Thorn, CA | 1 |
| Zhang, L | 1 |
| Webb, D | 1 |
| Jeong, JH | 1 |
| Choi, BY | 1 |
| Kho, AR | 1 |
| Lee, SH | 2 |
| Hong, DK | 1 |
| Lee, SY | 1 |
| Song, HK | 1 |
| Choi, HC | 1 |
| Suh, SW | 1 |
| Kitt, J | 1 |
| Irons, R | 1 |
| Al-Obaidi, M | 1 |
| Missouris, C | 1 |
| Bezerra da Silva, C | 1 |
| Pott, A | 1 |
| Elifio-Esposito, S | 1 |
| Dalarmi, L | 1 |
| Fialho do Nascimento, K | 1 |
| Moura Burci, L | 1 |
| de Oliveira, M | 1 |
| de Fátima Gaspari Dias, J | 1 |
| Warumby Zanin, SM | 1 |
| Gomes Miguel, O | 1 |
| Dallarmi Miguel, M | 1 |
| Saghafi, MM | 1 |
| Pregelj, P | 1 |
| Zivin, M | 1 |
| Farag, A | 1 |
| Averill, A | 1 |
| Bontempi, B | 1 |
| Whelan, KT | 1 |
| Risbrough, VB | 1 |
| Lloyd, GK | 1 |
| Menzaghi, F | 1 |
| Haug, KH | 1 |
| Myhrer, T | 1 |
| Fonnum, F | 1 |
| Babic, T | 1 |
| Zurak, N | 1 |
1 trial available for donepezil and Absence Seizure
| Article | Year |
|---|---|
Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Cognition; Donepezil; Enzyme-Link | 2017 |
10 other studies available for donepezil and Absence Seizure
| Article | Year |
|---|---|
Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome.
Topics: Animals; Disease Models, Animal; Donepezil; Epilepsies, Myoclonic; Male; Mice; Mutation; NAV1.1 Volt | 2019 |
Design and Synthesis of γ- and δ-Lactam M
Topics: Allosteric Regulation; Amphetamine; Animals; Ataxia; Diarrhea; Dogs; Donepezil; Drug Design; Female; | 2017 |
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure.
Topics: Animals; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Administrati | 2017 |
A case of donepezil-related torsades de pointes.
Topics: Aged, 80 and over; Alzheimer Disease; Cardiopulmonary Resuscitation; Donepezil; Electrocardiography; | 2015 |
Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina.
Topics: Animals; Cholinesterase Inhibitors; Convulsants; Donepezil; Galantamine; Indans; Locomotion; Models, | 2016 |
Donepezil inhibits diisopropylfluorophosphate-induced seizures and up-regulation of synaptotagmin 4 mRNA.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Anticonvulsants; Brain; Cholinesterase Inhibitors; Don | 2010 |
Dalfampridine: is the seizure risk greater than previously thought?
Topics: 4-Aminopyridine; Donepezil; Follow-Up Studies; Humans; Indans; Middle Aged; Multiple Sclerosis; Pipe | 2013 |
Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors.
Topics: Age Factors; Animals; Attention; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cogni | 2003 |
The combination of donepezil and procyclidine protects against soman-induced seizures in rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Body Temperature; Brain; Convulsants; Donepezil; Elect | 2007 |
Convulsions induced by donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Piperidines; Se | 1999 |