donepezil has been researched along with ALS - Amyotrophic Lateral Sclerosis in 2 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurodegenerative diseases including Alzheimer's disease are complex to tackle because of the complexity of the brain, both in structure and function." | 1.46 | Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases. ( Emon, MA; Hofmann-Apitius, M; Karki, R; Kodamullil, AT; Younesi, E, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, SY | 1 |
| Cho, HY | 1 |
| Oh, JP | 1 |
| Park, J | 1 |
| Bae, SH | 1 |
| Park, H | 1 |
| Kim, EJ | 1 |
| Lee, JH | 1 |
| Emon, MA | 1 |
| Kodamullil, AT | 1 |
| Karki, R | 1 |
| Younesi, E | 1 |
| Hofmann-Apitius, M | 1 |
2 other studies available for donepezil and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progression; Donepezil; HeLa | 2023 |
Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Computational Biology; Computer Simulation; Cyclos | 2017 |