domperidone has been researched along with Ventricular Fibrillation in 5 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because dopaminergic receptor agonists reduce sympathetic outflow, this study assessed effectiveness of the available dopaminergic agonist, bromocriptine, in slowing or terminating ouabain-induced ventricular tachycardia in anesthetized dogs." | 7.67 | Bromocriptine treatment of digitalis-induced ventricular tachyarrhythmias: studies in a canine model. ( Benditt, DG; Benson, DW; Detloff, BL; Kao, A; Kriett, JM; Pritzker, MR; Tobler, HG, 1984) |
| "The effect of a dopamine agonist, bromocriptine, on ventricular fibrillation (VF) threshold was studied in anaesthetised dogs." | 7.66 | Reduction in vulnerability to ventricular fibrillation by bromocriptine, a dopamine agonist. ( Desilva, RD; Falk, RH; Lown, B, 1981) |
| " Because dopaminergic receptor agonists reduce sympathetic outflow, this study assessed effectiveness of the available dopaminergic agonist, bromocriptine, in slowing or terminating ouabain-induced ventricular tachycardia in anesthetized dogs." | 3.67 | Bromocriptine treatment of digitalis-induced ventricular tachyarrhythmias: studies in a canine model. ( Benditt, DG; Benson, DW; Detloff, BL; Kao, A; Kriett, JM; Pritzker, MR; Tobler, HG, 1984) |
| "The effect of a dopamine agonist, bromocriptine, on ventricular fibrillation (VF) threshold was studied in anaesthetised dogs." | 3.66 | Reduction in vulnerability to ventricular fibrillation by bromocriptine, a dopamine agonist. ( Desilva, RD; Falk, RH; Lown, B, 1981) |
| "Domperidone is a dopamine antagonist with anti-nausea and anti-emetic activity." | 1.37 | Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death. ( Hondeghem, LM, 2011) |
| "Recently, a 4-fold increase in risk of sudden cardiac death (SCD) was reported for domperidone in a study that focused on corrected QT interval (QTc)-prolonging drugs as a class and their association with SCD." | 1.36 | Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands. ( Dieleman, JP; Sturkenboom, MC; van Herpen, G; van Noord, C; Verhamme, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Noord, C | 1 |
| Dieleman, JP | 1 |
| van Herpen, G | 1 |
| Verhamme, K | 1 |
| Sturkenboom, MC | 1 |
| Hondeghem, LM | 1 |
| Kao, A | 1 |
| Kriett, JM | 1 |
| Tobler, HG | 1 |
| Detloff, BL | 1 |
| Pritzker, MR | 1 |
| Benson, DW | 1 |
| Benditt, DG | 1 |
| Falk, RH | 1 |
| Desilva, RD | 1 |
| Lown, B | 1 |
| Bruera, E | 1 |
| Villamayor, R | 1 |
| Roca, E | 1 |
| Barugel, M | 1 |
| Tronge, J | 1 |
| Chacon, R | 1 |
5 other studies available for domperidone and Ventricular Fibrillation
| Article | Year |
|---|---|
Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands.
Topics: Antiemetics; Case-Control Studies; Death, Sudden, Cardiac; Domperidone; Dose-Response Relationship, | 2010 |
Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death.
Topics: Action Potentials; Animals; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Heart Conduct | 2011 |
Bromocriptine treatment of digitalis-induced ventricular tachyarrhythmias: studies in a canine model.
Topics: Animals; Blood Pressure; Bromocriptine; Dogs; Domperidone; Female; Haloperidol; Male; Ouabain; Preme | 1984 |
Reduction in vulnerability to ventricular fibrillation by bromocriptine, a dopamine agonist.
Topics: Animals; Benzimidazoles; Bromocriptine; Dogs; Domperidone; Dopamine Antagonists; Female; Haloperidol | 1981 |
Q-T interval prolongation and ventricular fibrillation with i.v. domperidone.
Topics: Domperidone; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Humans; Infu | 1986 |