domperidone has been researched along with Torsade de Pointes in 10 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders." | 6.46 | Domperidone and long QT syndrome. ( Giorgi, G; Rossi, M, 2010) |
| "Observational retrospective studies have linked domperidone and prolonged QT interval, ventricular arrhythmias and risk of sudden death." | 3.85 | [Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database]. ( Auffret, M; Béné, J; Gautier, S; Rochoy, M, 2017) |
| " In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with hypokalemia and hypomagnesaemia." | 3.76 | Multifactorial QT interval prolongation. ( Baranchuk, A; Digby, G; Machaalany, J; Malik, P; Methot, M; Redfearn, D; Simpson, CS, 2010) |
| "Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders." | 2.46 | Domperidone and long QT syndrome. ( Giorgi, G; Rossi, M, 2010) |
| "Domperidone was prescribed among 1438 deliveries at a rate of 1." | 1.48 | Domperidone for insufficient lactation in England 2002-2015: A drug utilization study with interrupted time series analysis. ( Filion, KB; Mehrabadi, A; Platt, RW; Reynier, P, 2018) |
| "Domperidone is a dopamine antagonist with anti-nausea and anti-emetic activity." | 1.37 | Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death. ( Hondeghem, LM, 2011) |
| "Recently, a 4-fold increase in risk of sudden cardiac death (SCD) was reported for domperidone in a study that focused on corrected QT interval (QTc)-prolonging drugs as a class and their association with SCD." | 1.36 | Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands. ( Dieleman, JP; Sturkenboom, MC; van Herpen, G; van Noord, C; Verhamme, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mehrabadi, A | 1 |
| Reynier, P | 1 |
| Platt, RW | 1 |
| Filion, KB | 1 |
| Rojas-Fernandez, C | 1 |
| Stephenson, AL | 1 |
| Fischer, HD | 1 |
| Wang, X | 1 |
| Mestre, T | 1 |
| Hutson, JR | 1 |
| Pondal, M | 1 |
| Lee, DS | 1 |
| Rochon, PA | 1 |
| Marras, C | 1 |
| Rochoy, M | 1 |
| Auffret, M | 1 |
| Béné, J | 1 |
| Gautier, S | 1 |
| Collins, KK | 1 |
| Sondheimer, JM | 1 |
| Rossi, M | 1 |
| Giorgi, G | 1 |
| Digby, G | 1 |
| Machaalany, J | 1 |
| Malik, P | 1 |
| Methot, M | 1 |
| Simpson, CS | 1 |
| Redfearn, D | 1 |
| Baranchuk, A | 1 |
| van Noord, C | 1 |
| Dieleman, JP | 1 |
| van Herpen, G | 1 |
| Verhamme, K | 1 |
| Sturkenboom, MC | 1 |
| Hondeghem, LM | 1 |
1 review available for domperidone and Torsade de Pointes
| Article | Year |
|---|---|
Domperidone and long QT syndrome.
Topics: Adult; Animals; Arrhythmias, Cardiac; Child; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonis | 2010 |
9 other studies available for domperidone and Torsade de Pointes
| Article | Year |
|---|---|
Domperidone for insufficient lactation in England 2002-2015: A drug utilization study with interrupted time series analysis.
Topics: Adult; Cohort Studies; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Dose-Response Rela | 2018 |
Current use of domperidone and co-prescribing of medications that increase its arrhythmogenic potential among older adults: a population-based cohort study in Ontario, Canada.
Topics: Aged; Aged, 80 and over; Antiemetics; Cohort Studies; Cytochrome P-450 CYP3A Inhibitors; Domperidone | 2014 |
[Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Car | 2017 |
Domperidone and sudden death. Cardiac rhythm disorders: QT interval prolongation.
Topics: Antiemetics; Arrhythmias, Cardiac; Canada; Death, Sudden, Cardiac; Domperidone; Humans; Long QT Synd | 2008 |
Domperidone-induced QT prolongation: add another drug to the list.
Topics: Animals; Cisapride; Domperidone; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactio | 2008 |
Multifactorial QT interval prolongation.
Topics: Alcoholism; Amiodarone; Antipsychotic Agents; Arrhythmias, Cardiac; Biomarkers; Citalopram; Cyclohex | 2010 |
Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands.
Topics: Antiemetics; Case-Control Studies; Death, Sudden, Cardiac; Domperidone; Dose-Response Relationship, | 2010 |
Domperidone: QT prolongation in infants.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; France; Gastroesophageal Reflux; Humans; Infant; Inf | 2011 |
Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death.
Topics: Action Potentials; Animals; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Heart Conduct | 2011 |