domperidone has been researched along with Tachycardia, Ventricular in 4 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone is a proposed treatment of orthostatic hypotension (OH) in Parkinson's disease (PD)." | 2.55 | Domperidone for Hypotension in Parkinson's Disease: A Systematic Review. ( Bacchi, S; Chim, I; Kramer, P; Postuma, RB, 2017) |
| "Domperidone use may increase the risk of VT/SCD in patients with PD, particularly those with a history of cardiovascular disease." | 1.43 | Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease. ( Blais, L; Bugden, S; Dell'Aniello, S; Dormuth, C; Ernst, P; Evans, C; Khairy, P; Marras, C; Renoux, C; Steele, R; Tamim, H; Turin, TC, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakhlé, G | 1 |
| Brophy, JM | 1 |
| Renoux, C | 2 |
| Khairy, P | 2 |
| Bélisle, P | 1 |
| LeLorier, J | 1 |
| Bacchi, S | 1 |
| Chim, I | 1 |
| Kramer, P | 1 |
| Postuma, RB | 1 |
| Dell'Aniello, S | 1 |
| Marras, C | 1 |
| Bugden, S | 1 |
| Turin, TC | 1 |
| Blais, L | 1 |
| Tamim, H | 1 |
| Evans, C | 1 |
| Steele, R | 1 |
| Dormuth, C | 1 |
| Ernst, P | 1 |
| Hondeghem, LM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Domperidone Use in Parkinson's Disease and Risk of Sudden Cardiac Death[NCT02500108] | 214,962 participants (Actual) | Observational | 2013-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for domperidone and Tachycardia, Ventricular
| Article | Year |
|---|---|
Domperidone for Hypotension in Parkinson's Disease: A Systematic Review.
Topics: Animals; Arrhythmias, Cardiac; Databases, Bibliographic; Death, Sudden, Cardiac; Domperidone; Dopami | 2017 |
Domperidone: limited benefits with significant risk for sudden cardiac death.
Topics: Action Potentials; Animals; Antiemetics; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; | 2013 |
2 other studies available for domperidone and Tachycardia, Ventricular
| Article | Year |
|---|---|
Domperidone increases harmful cardiac events in Parkinson's disease: A Bayesian re-analysis of an observational study.
Topics: Aged; Antiparkinson Agents; Bayes Theorem; Death, Sudden, Cardiac; Domperidone; Female; Humans; Male | 2021 |
Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiemetics; Canada; Cohort Studies; Death, Sudden, Cardiac; Domperidone; F | 2016 |