domperidone has been researched along with Symptom Cluster in 6 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized, double-blind, double-dummy, positive-controlled study compared the efficacy and safety of cinitapride (1 mg) and domperidone (10 mg) tid for 4 weeks in 383 consecutive patients with mild to moderate, postprandial distress syndrome-predominant dyspeptic symptoms according to Rome III criteria." | 9.19 | Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. ( Chen, J; Ding, Y; Du, Y; Gao, J; Gong, L; Guo, J; Li, Z; Luo, H; Song, X; Su, T; Tian, D; Wang, B; Wang, S; Xie, W; Xu, J; Zhang, Z; Zou, D; Zuo, C, 2014) |
| "This randomized, double-blind, double-dummy, positive-controlled study compared the efficacy and safety of cinitapride (1 mg) and domperidone (10 mg) tid for 4 weeks in 383 consecutive patients with mild to moderate, postprandial distress syndrome-predominant dyspeptic symptoms according to Rome III criteria." | 5.19 | Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. ( Chen, J; Ding, Y; Du, Y; Gao, J; Gong, L; Guo, J; Li, Z; Luo, H; Song, X; Su, T; Tian, D; Wang, B; Wang, S; Xie, W; Xu, J; Zhang, Z; Zou, D; Zuo, C, 2014) |
| "The response to domperidone (a dopamine blocking agent) of serum prolactin (PRL) levels was compared in 3 patients with amenorrhea-galactorrhea without evidence of a pituitary tumor, 23 patients with prolactinomas (10 cases with histologic confirmation), 7 patients with histologically verified large nonfunctioning pituitary adenomas with normal or moderately elevated basal PRL levels, and 6 patients with histologically verified craniopharyngiomas (3 with normal basal PRL levels and 3 with elevated PRL levels)." | 3.67 | Dysfunction of dopaminergic regulation of prolactin in patients with functioning and nonfunctioning pituitary adenomas and craniopharyngiomas. ( Cornejo, J; Garza-Flores, J; Martinez-Campos, A; Velasco, F, 1985) |
| "Functional vomiting is rare and presents with more frequent vomiting episodes." | 2.44 | Functional nausea and vomiting. ( Talley, NJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, Y | 1 |
| Su, T | 1 |
| Song, X | 1 |
| Gao, J | 1 |
| Zou, D | 1 |
| Zuo, C | 1 |
| Xie, W | 1 |
| Wang, B | 1 |
| Zhang, Z | 2 |
| Xu, J | 1 |
| Tian, D | 1 |
| Luo, H | 1 |
| Wang, S | 1 |
| Chen, J | 1 |
| Guo, J | 1 |
| Gong, L | 1 |
| Ding, Y | 1 |
| Li, Z | 1 |
| Talley, NJ | 1 |
| Svintsyts'kyĭ, AS | 1 |
| Dzeman, MI | 1 |
| Shylo, HV | 1 |
| Mandel, H | 1 |
| Tirosh, E | 1 |
| Berant, M | 1 |
| Rogers, AI | 1 |
| Martinez-Campos, A | 1 |
| Cornejo, J | 1 |
| Garza-Flores, J | 1 |
| Velasco, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Double-dummy, Active Drug Parallel Controlled, Multi-center Clinical Trial on the Efficacy and Safety of Cinitapride Tablets in the Treatment of Mild to Moderate Functional Dyspepsia[NCT01355276] | Phase 3 | 400 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for domperidone and Symptom Cluster
| Article | Year |
|---|---|
Functional nausea and vomiting.
Topics: Acute Disease; Antidepressive Agents, Tricyclic; Antiemetics; Chronic Disease; Diagnosis, Differenti | 2007 |
1 trial available for domperidone and Symptom Cluster
| Article | Year |
|---|---|
Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia.
Topics: Adolescent; Adult; Aged; Benzamides; Domperidone; Dopamine Antagonists; Dopamine D2 Receptor Antagon | 2014 |
4 other studies available for domperidone and Symptom Cluster
| Article | Year |
|---|---|
[A case of the successful use of Motilium in treating reflux disease against a background of the hypothalamic syndrome of traumatic origin].
Topics: Adult; Antiemetics; Brain Injuries; Domperidone; Dopamine Antagonists; Esophagitis, Peptic; Female; | 1999 |
Sandifer syndrome reconsidered.
Topics: Antacids; Child; Child, Preschool; Cimetidine; Domperidone; Dystonia; Female; Gastroesophageal Reflu | 1989 |
Gastric emptying disorders.
Topics: Bethanechol; Bethanechol Compounds; Domperidone; Food; Gastric Emptying; Gastric Fundus; Humans; Met | 1985 |
Dysfunction of dopaminergic regulation of prolactin in patients with functioning and nonfunctioning pituitary adenomas and craniopharyngiomas.
Topics: Adenoma; Adolescent; Adult; Amenorrhea; Craniopharyngioma; Domperidone; Dopamine; Female; Galactorrh | 1985 |