domperidone has been researched along with Substance Withdrawal Syndrome in 7 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone is a dopamine D₂ receptor antagonist that does not usually cross the blood-brain barrier." | 5.37 | Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia. ( Bocti, C; Hottin, P; Landry, J; Roy-Desruisseaux, J; Tessier, D; Trudel, JF, 2011) |
| "The patient presented with withdrawal symptoms after gradual taper and discontinuation of domperidone." | 1.48 | Case report: domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation. ( Doyle, M; Grossman, M, 2018) |
| "Domperidone is a dopamine D₂ receptor antagonist that does not usually cross the blood-brain barrier." | 1.37 | Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia. ( Bocti, C; Hottin, P; Landry, J; Roy-Desruisseaux, J; Tessier, D; Trudel, JF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doyle, M | 1 |
| Grossman, M | 1 |
| Novak, G | 1 |
| Seeman, P | 1 |
| Le Foll, B | 1 |
| Roy-Desruisseaux, J | 1 |
| Landry, J | 1 |
| Bocti, C | 1 |
| Tessier, D | 1 |
| Hottin, P | 1 |
| Trudel, JF | 1 |
| Annunziato, L | 1 |
| Amoroso, S | 1 |
| Di Renzo, G | 1 |
| Argenzio, F | 1 |
| Aurilio, C | 1 |
| Grella, A | 1 |
| Quattrone, A | 1 |
| Rampello, L | 1 |
| Raffaele, R | 1 |
| Nicoletti, G | 1 |
| Le Pira, F | 1 |
| Vecchio, I | 1 |
| Malaguarnera, M | 1 |
| Drago, F | 1 |
| Farzin, D | 1 |
| Rupniak, NM | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
1 trial available for domperidone and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Neurobehavioral syndrome induced by H2-receptor blocker withdrawal: possible role of prolactin.
Topics: Adult; Anorexia; Antiemetics; Cimetidine; Domperidone; Female; Histamine H2 Antagonists; Humans; Mal | 1997 |
6 other studies available for domperidone and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Case report: domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation.
Topics: Adult; Breast Feeding; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; | 2018 |
Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity.
Topics: Animals; Behavior, Animal; Corpus Striatum; Domperidone; Dopamine; Humans; Male; Nicotine; Rats; Rat | 2010 |
Domperidone-induced tardive dyskinesia and withdrawal psychosis in an elderly woman with dementia.
Topics: Aged; Blood-Brain Barrier; Dementia; Domperidone; Dopamine Antagonists; Dopamine D2 Receptor Antagon | 2011 |
Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome.
Topics: Adult; Domperidone; Dopamine; Ethanol; Female; Growth Hormone; Humans; Male; Receptors, Dopamine; St | 1983 |
Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice.
Topics: Animals; Apomorphine; Behavior, Animal; Benzazepines; Dextromethorphan; Domperidone; Dopamine Agonis | 1999 |
Pharmacological characterisation of spontaneous or drug-associated purposeless chewing movements in rats.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Domperidone; Dopamine; Female; Flupenthixol; gamma-Ami | 1985 |