domperidone has been researched along with Sensitivity and Specificity in 11 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Its main pharmacokinetic parameters were: Tmax = (0." | 2.70 | Determination of domperidone in human plasma by LC-MS and its pharmacokinetics in healthy Chinese volunteers. ( Cai, XH; Gao, L; Wang, GJ; Wu, MS, 2002) |
| "Diphenhydramine was used as the internal standard." | 1.39 | Development and validation of UPLC-MS/MS method for determination of domperidone in human plasma and its pharmacokinetic application. ( Jing, L; Li, F; Qin, F; Wang, X; Xiong, Z; Zhu, Q, 2013) |
| "A stability-indicating thin layer chromatographic (TLC) method for determination of dexrabeprazole (DEX) and domperidone (DOM) in combined dosage form has been developed and validated." | 1.36 | Stability-indicating TLC-densitometric method for estimation of dexrabeprazole and domperidone in pharmaceutical dosage form. ( Chitlange, SS; Mulla, AI; Pawbake, GR; Wankhede, SB, 2010) |
| " The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form." | 1.33 | "Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry". ( El-Ghany, NA; Wahdan, T, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Chitlange, SS | 1 |
| Mulla, AI | 1 |
| Pawbake, GR | 1 |
| Wankhede, SB | 1 |
| Wang, X | 1 |
| Qin, F | 1 |
| Jing, L | 1 |
| Zhu, Q | 1 |
| Li, F | 1 |
| Xiong, Z | 1 |
| Wahdan, T | 1 |
| El-Ghany, NA | 1 |
| Sivakumar, T | 1 |
| Manavalan, R | 1 |
| Muralidharan, C | 1 |
| Valliappan, K | 1 |
| Michaud, V | 1 |
| Simard, C | 1 |
| Turgeon, J | 1 |
| Walash, MI | 1 |
| Belal, F | 1 |
| El-Enany, N | 1 |
| Abdelal, AA | 1 |
| Yamamoto, K | 1 |
| Hagino, M | 1 |
| Kotaki, H | 1 |
| Iga, T | 1 |
| Zavitsanos, AP | 1 |
| MacDonald, C | 1 |
| Bassoo, E | 1 |
| Gopaul, D | 1 |
| Wu, MS | 1 |
| Gao, L | 1 |
| Cai, XH | 1 |
| Wang, GJ | 1 |
| Smit, MJ | 1 |
| Sutherland, FC | 1 |
| Hundt, HK | 1 |
| Swart, KJ | 1 |
| Hundt, AF | 1 |
| Els, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology[NCT03221855] | Early Phase 1 | 30 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for domperidone and Sensitivity and Specificity
| Article | Year |
|---|---|
Determination of domperidone in human plasma by LC-MS and its pharmacokinetics in healthy Chinese volunteers.
Topics: Adult; Chromatography, Liquid; Domperidone; Dopamine Antagonists; Humans; Male; Sensitivity and Spec | 2002 |
10 other studies available for domperidone and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Stability-indicating TLC-densitometric method for estimation of dexrabeprazole and domperidone in pharmaceutical dosage form.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, Thin Layer; Densitometry; Domperidone; Dosa | 2010 |
Development and validation of UPLC-MS/MS method for determination of domperidone in human plasma and its pharmacokinetic application.
Topics: Chromatography, High Pressure Liquid; Diphenhydramine; Domperidone; Drug Stability; Humans; Linear M | 2013 |
"Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry".
Topics: Antiemetics; Carbon; Domperidone; Electrochemistry; Electrodes; Hydrogen-Ion Concentration; Oxidatio | 2005 |
Multi-criteria decision making approach and experimental design as chemometric tools to optimize HPLC separation of domperidone and pantoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetonitriles; Analysis of Variance; Anti-Ulcer Agents; Cal | 2007 |
An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies.
Topics: Calibration; Chromatography, High Pressure Liquid; Domperidone; Dopamine Antagonists; In Vitro Techn | 2007 |
Second-derivative synchronous fluorometric method for the simultaneous determination of cinnarizine and domperidone in pharmaceutical preparations. Application to biological fluids.
Topics: Adult; Calcium Channel Blockers; Cinnarizine; Domperidone; Dopamine Antagonists; Fluorometry; Humans | 2008 |
Quantitative determination of domperidone in rat plasma by high-performance liquid chromatography with fluorescence detection.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Domperidone; Dopamine Antagonists; Rats; | 1998 |
Determination of domperidone in human serum and human breast milk by high-performance liquid chromatography-electrospray mass spectrometry.
Topics: Antiemetics; Artifacts; Chromatography, High Pressure Liquid; Domperidone; Humans; Mass Spectrometry | 1999 |
Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of domperidone in human plasma.
Topics: Chromatography, High Pressure Liquid; Domperidone; Dopamine Antagonists; Humans; Sensitivity and Spe | 2002 |