domperidone has been researched along with Restless Legs Syndrome in 4 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Restless Legs Syndrome: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dopaminergic treatment with levodopa (L-dopa) has been proven as the treatment of first choice in patients with restless leg syndrome (RLS)." | 9.08 | Treatment of restless leg syndrome with pergolide--an open clinical trial. ( Oertel, WH; Stiasny, K; Trenkwalder, C; Wetter, TC; Winkelmann, J, 1998) |
| "From two Parkinson's disease cohorts, we assessed restless legs prevalence according to standard criteria, in patients taking vs." | 5.39 | Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease. ( Bayard, S; Carlander, B; Cochen De Cock, V; Dauvilliers, Y; Galatas, C; Postuma, RB; Rios Romenets, S; Wolfson, C, 2013) |
| "Dopaminergic treatment with levodopa (L-dopa) has been proven as the treatment of first choice in patients with restless leg syndrome (RLS)." | 5.08 | Treatment of restless leg syndrome with pergolide--an open clinical trial. ( Oertel, WH; Stiasny, K; Trenkwalder, C; Wetter, TC; Winkelmann, J, 1998) |
| "From two Parkinson's disease cohorts, we assessed restless legs prevalence according to standard criteria, in patients taking vs." | 1.39 | Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease. ( Bayard, S; Carlander, B; Cochen De Cock, V; Dauvilliers, Y; Galatas, C; Postuma, RB; Rios Romenets, S; Wolfson, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rios Romenets, S | 1 |
| Dauvilliers, Y | 1 |
| Cochen De Cock, V | 1 |
| Carlander, B | 1 |
| Bayard, S | 1 |
| Galatas, C | 1 |
| Wolfson, C | 1 |
| Postuma, RB | 1 |
| Arnulf, I | 1 |
| Konofal, E | 1 |
| Gauthier, C | 1 |
| Chedru, F | 1 |
| Chang, CC | 1 |
| Shiah, IS | 1 |
| Chang, HA | 1 |
| Mao, WC | 1 |
| Winkelmann, J | 1 |
| Wetter, TC | 1 |
| Stiasny, K | 1 |
| Oertel, WH | 1 |
| Trenkwalder, C | 1 |
1 trial available for domperidone and Restless Legs Syndrome
| Article | Year |
|---|---|
Treatment of restless leg syndrome with pergolide--an open clinical trial.
Topics: Aged; Antiparkinson Agents; Domperidone; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1998 |
3 other studies available for domperidone and Restless Legs Syndrome
| Article | Year |
|---|---|
Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.
Topics: Aged; Blood-Brain Barrier; Domperidone; Dopamine Antagonists; Female; Humans; Male; Middle Aged; Par | 2013 |
Severe restless legs syndrome presenting as intractable insomnia.
Topics: Chronic Disease; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, D | 2004 |
Does domperidone potentiate mirtazapine-associated restless legs syndrome?
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Domperidone; Dopamine Antagonis | 2006 |