domperidone has been researched along with Parkinsonian Disorders in 2 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "domperidone was administered to both 6-hydroxydopamine Parkinsonism models and regular Wistar rats." | 1.51 | Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone. ( Britto, LRG; Faber, J; Ferraz, HB; Oliveira, LF; Rodrigues, LD; Scorza, CA; Scorza, FA; Shinoda, L, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodrigues, LD | 1 |
| Oliveira, LF | 1 |
| Shinoda, L | 1 |
| Scorza, CA | 1 |
| Faber, J | 1 |
| Ferraz, HB | 1 |
| Britto, LRG | 1 |
| Scorza, FA | 1 |
| Zhao, T | 1 |
| Zondervan-van der Linde, H | 1 |
| Severijnen, LA | 1 |
| Oostra, BA | 1 |
| Willemsen, R | 1 |
| Bonifati, V | 1 |
2 other studies available for domperidone and Parkinsonian Disorders
| Article | Year |
|---|---|
Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone.
Topics: Animals; Behavior, Animal; Cardiovascular Diseases; Disease Models, Animal; Domperidone; Dopamine An | 2019 |
Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish.
Topics: Animals; Apomorphine; Body Patterning; Brain; Disease Models, Animal; Domperidone; Dopamine; Dopamin | 2012 |