domperidone has been researched along with Muscle Contraction in 29 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that domperidone stimulates gastric muscle contraction by antagonizing the inhibitory effects of dopamine on postsynaptic cholinergic neurons in the myenteric plexus, the effects of dopamine on circular muscle from the body of the guinea pig stomach were examined." | 3.68 | Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs. ( Kurosawa, S; Owyang, C; Takahashi, T; Wiley, JW, 1991) |
| "The regular dosage of cimetidine showed an inhibitory effect on the motility of SO, while famotidine had no obvious effects otherwise." | 2.73 | Choledochoscope manometry about different drugs on the Sphincter of Oddi. ( Chen, JZ; Kong, J; Li, ZS; Shi, G; Wang, W; Wu, SD; Zhang, XB, 2008) |
| "Pretreatment with domperidone i." | 1.28 | Prejunctional adrenoceptor activity of N-0437: a relatively selective DA2 dopamine receptor agonist. ( Burke, JA; Chan, MF; Crosson, CE; Potter, DE, 1990) |
| "Domperidone was a potent, competitive antagonist at neuronal (pA2 = 7." | 1.27 | Peripheral dopamine receptor blockade by SCH 23390 and domperidone in vitro. ( Drew, GM; Hilditch, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (62.07) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nam, Y | 1 |
| Lee, JM | 1 |
| Wang, Y | 1 |
| Ha, HS | 1 |
| Sohn, UD | 1 |
| Kong, J | 1 |
| Wu, SD | 1 |
| Zhang, XB | 1 |
| Li, ZS | 1 |
| Shi, G | 1 |
| Wang, W | 1 |
| Chen, JZ | 1 |
| Li, C | 1 |
| Qian, W | 1 |
| Hou, X | 1 |
| Ozaki, M | 2 |
| Masuda, Y | 1 |
| Kishioka, S | 2 |
| Yamamoto, H | 2 |
| Nagatomo, T | 1 |
| Maeda, T | 1 |
| Ennis, C | 1 |
| Cox, B | 1 |
| Sahyoun, HA | 2 |
| Costall, B | 3 |
| Naylor, RJ | 3 |
| Schuurkes, JA | 2 |
| Van Nueten, JM | 2 |
| Tan, CC | 1 |
| Eyre-Brook, IA | 1 |
| Smallwood, R | 1 |
| Johnson, AG | 1 |
| Mangel, AW | 1 |
| Stavorski, JR | 1 |
| Pendleton, RG | 1 |
| Brock-Utne, JG | 1 |
| Yoshida, Y | 1 |
| Takayanagi, I | 1 |
| Murakami, H | 1 |
| Maroy, B | 1 |
| Chermet, J | 1 |
| Tubiana, JM | 1 |
| Chalut, J | 1 |
| Odinot, JM | 1 |
| Defilippi, C | 1 |
| Gomez, E | 1 |
| Lefebvre, RA | 2 |
| Willems, JL | 1 |
| Takahashi, T | 1 |
| Kurosawa, S | 1 |
| Wiley, JW | 1 |
| Owyang, C | 1 |
| Crosson, CE | 1 |
| Burke, JA | 1 |
| Chan, MF | 1 |
| Potter, DE | 1 |
| Matsuo, S | 1 |
| Neya, T | 1 |
| Yamasato, T | 1 |
| Iwanaga, Y | 1 |
| Miyashita, N | 1 |
| Morikawa, K | 1 |
| Mizumoto, A | 1 |
| Kondo, Y | 1 |
| Itoh, Z | 1 |
| Yamauchi, M | 1 |
| Kobayashi, Y | 1 |
| Hattori, K | 1 |
| Yamada, K | 1 |
| Nakase, A | 1 |
| Lang, IM | 1 |
| Marvig, J | 1 |
| Hilditch, A | 1 |
| Drew, GM | 1 |
| Sanger, GJ | 1 |
| Lombardi, DM | 1 |
| Grous, M | 1 |
| Fine, CF | 1 |
| Barone, FC | 1 |
| Fowler, PJ | 1 |
| Phyall, WB | 1 |
| Rush, JA | 1 |
| Ormsbee, HS | 1 |
| Lee, KY | 1 |
| Park, HJ | 1 |
| Chey, WY | 1 |
| Helsen, LF | 1 |
3 trials available for domperidone and Muscle Contraction
| Article | Year |
|---|---|
Choledochoscope manometry about different drugs on the Sphincter of Oddi.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Cholecystectomy; Cimetidine; Domperidone; Endoscopes; Fa | 2008 |
Domperidone antagonizes the relaxant effect atropine on the lower esophageal sphincter.
Topics: Adult; Antiemetics; Atropine; Benzimidazoles; Domperidone; Esophagogastric Junction; Gastroesophagea | 1980 |
[Comparative radiologic study of 2 agents modifying digestive behavior].
Topics: Adult; Aged; Benzimidazoles; Digestive System; Domperidone; Duodenum; Female; Humans; Male; Metoclop | 1980 |
26 other studies available for domperidone and Muscle Contraction
| Article | Year |
|---|---|
The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function.
Topics: Animals; Benzamides; Carbachol; Cats; Cells, Cultured; Domperidone; Dose-Response Relationship, Drug | 2016 |
Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit.
Topics: Animals; Carbachol; Domperidone; Gastrointestinal Agents; Gastrointestinal Motility; Indoles; Male; | 2009 |
Actions of domperidone on the opioid system in isolated guinea-pig ileum: differences between dopamine antagonists on opioid system.
Topics: Animals; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In | 2003 |
Pharmacological differences between Liu-Jun-Zi-Tang, a traditional Chinese herbal medicine, and domperidone on isolated guinea-pig ileum.
Topics: Acetylcholine; Animals; Domperidone; Drugs, Chinese Herbal; Electric Stimulation; Guinea Pigs; Ileum | 2006 |
The dopamine receptor antagonist domperidone is also a competitive antagonist at alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Benzimidazoles; Domperidone; Female; Guinea | 1980 |
On the ability of domperidone to selectively inhibit catecholamine-induced relaxation of circular smooth muscle of guinea-pig stomach.
Topics: Animals; Catecholamines; Domperidone; Dopamine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Mal | 1982 |
Catecholamine-induced relaxation and contraction of the lower oesophageal and pyloric sphincters of guinea-pig stomach: modification by domperidone.
Topics: Animals; Catecholamines; Domperidone; Dopamine; Esophagogastric Junction; Guinea Pigs; In Vitro Tech | 1982 |
Effects of dopamine and its antagonist domperidone cannot be explained by an effect on alpha 1-adrenergic receptors.
Topics: Animals; Benzimidazoles; Domperidone; Dopamine; Dopamine Antagonists; Guinea Pigs; In Vitro Techniqu | 1981 |
Neuronally mediated contraction responses of guinea-pig stomach smooth muscle preparations: modification by benzamide derivatives does not reflect a dopamine antagonist action.
Topics: Animals; Benzamides; Domperidone; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Technique | 1984 |
Human antroduodenal motility, pyloric closure, and domperidone.
Topics: Adult; Domperidone; Double-Blind Method; Duodenum; Endoscopy; Female; Gastrointestinal Motility; Hum | 1984 |
Effects of bethanechol, metoclopramide, and domperidone on antral contractions in cats and dogs.
Topics: Animals; Bethanechol Compounds; Cats; Dogs; Domperidone; Metoclopramide; Models, Biological; Muscle | 1983 |
Dopamine and its antagonists on molluscan smooth muscle.
Topics: Animals; Benzimidazoles; Bivalvia; Domperidone; Dopamine; Dopamine Antagonists; In Vitro Techniques; | 1981 |
Short report: effect of two prokinetic drugs on the electrical and motor activity of the small bowel in dogs.
Topics: Animals; Dogs; Domperidone; Electrophysiology; Gastrointestinal Motility; Membrane Potentials; Muscl | 1993 |
Gastric relaxation by morphine, apomorphine and fentanyl in the conscious dog.
Topics: Animals; Apomorphine; Benzimidazoles; Dogs; Domperidone; Fentanyl; Haloperidol; Morphine; Muscle Con | 1979 |
The inhibitory effect of dopamine on cat gastric smooth muscle.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cats; Domperidone; Dopamine; Dop | 1992 |
Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs.
Topics: Animals; Domperidone; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Motility; | 1991 |
Prejunctional adrenoceptor activity of N-0437: a relatively selective DA2 dopamine receptor agonist.
Topics: Animals; Cats; Domperidone; Dopamine Agents; Electric Stimulation; In Vitro Techniques; Muscle Contr | 1990 |
Antroduodenal coordinated contractions as studied by chemical ablation of myenteric neurons in the gastroduodenal junctional zone.
Topics: Animals; Benzalkonium Compounds; Domperidone; Duodenum; Female; Male; Muscle Contraction; Muscle, Sm | 1991 |
A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine.
Topics: Animals; Benzamides; Benzyl Compounds; Cholinesterase Inhibitors; Dogs; Domperidone; Dopamine Antago | 1990 |
Dopamine-induced relaxation in human pulmonary arteries.
Topics: Aged; Dinoprost; Domperidone; Dopamine; Female; Fluphenazine; Haloperidol; Humans; Male; Middle Aged | 1989 |
Functional localization of specific receptors mediating gastrointestinal motor correlates of vomiting.
Topics: Animals; Apomorphine; Atropine; Copper; Copper Sulfate; Digestive System; Dogs; Domperidone; Female; | 1989 |
Peripheral dopamine receptor blockade by SCH 23390 and domperidone in vitro.
Topics: Animals; Antipsychotic Agents; Arteries; Benzazepines; Dinoprost; Domperidone; In Vitro Techniques; | 1985 |
Effects of metoclopramide and domperidone on cholinergically mediated contractions of human isolated stomach muscle.
Topics: Acetylcholine; Atropine; Carbachol; Domperidone; Electric Stimulation; Humans; In Vitro Techniques; | 1985 |
DA1 receptor mediates dopamine-induced relaxation of opossum lower esophageal sphincter in vitro.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Aporphines; Benzaz | 1986 |
Studies on mechanism of retching and vomiting in dogs. Effect of peripheral dopamine blocker on myoelectric changes in antrum and upper small intestine.
Topics: Animals; Copper; Copper Sulfate; Dogs; Domperidone; Dopamine; Duodenum; Electrophysiology; Jejunum; | 1985 |
A comparative study on the effects of domperidone, metoclopramide, clebopride and trimebutine on the gastro-duodenal preparation of the guinea pig.
Topics: Animals; Benzamides; Benzoates; Domperidone; Drug Antagonism; Duodenum; Female; Gastrointestinal Mot | 1985 |