domperidone has been researched along with Migraine Disorders in 28 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the safety of domperidone in the treatment of nausea associated with dihydroergotamine (DHE) infusion and headache." | 7.83 | Safety of domperidone in treating nausea associated with dihydroergotamine infusion and headache. ( Goadsby, PJ; Ito, H; Robbins, NM; Scheinman, MM, 2016) |
| " In the present studies, therefore, we used Suncus murinus, a species of insectivore capable of emesis, to investigate if the vanilloid receptor agonist resiniferatoxin is capable of modeling the emesis associated with migraine." | 7.73 | Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). ( Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C, 2005) |
| " The aim of this study was to compare the effectiveness and tolerability of a fixed combination of domperidone and paracetamol (Domperamol; Servier), which has anti-nauseant and anti-emetic activity, with sumatriptan 50 mg in moderate to severe migraine." | 5.09 | Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study. ( Ball, K; Dowson, A; Haworth, D, 2000) |
| "To determine the safety of domperidone in the treatment of nausea associated with dihydroergotamine (DHE) infusion and headache." | 3.83 | Safety of domperidone in treating nausea associated with dihydroergotamine infusion and headache. ( Goadsby, PJ; Ito, H; Robbins, NM; Scheinman, MM, 2016) |
| "Domperidone is a dopamine antagonist that has recently been released in Canada." | 3.76 | Domperidone, a new dopamine antagonist. ( Champion, MC; Hartnett, M; Yen, M, 1986) |
| " In the present studies, therefore, we used Suncus murinus, a species of insectivore capable of emesis, to investigate if the vanilloid receptor agonist resiniferatoxin is capable of modeling the emesis associated with migraine." | 3.73 | Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). ( Andrews, PL; Cheng, FH; Moreaux, B; Ngan, MP; Rudd, JA; Sam, TS; Wai, MK; Wan, C, 2005) |
| "Migraine suffers who experience spontaneous syncopes (syncopal migraine) during attacks exhibit a dramatic intolerance to bromocriptine, a dopamine agonist." | 3.66 | A new nonvascular interpretation of syncopal migraine. ( Boccuni, M; Bonciani, M; D'Egidio, P; Fanciullacci, M; Sicuteri, F, 1982) |
| "In conclusion, migraineurs show a lower threshold for dopamine receptor activation than normal subjects." | 2.68 | Dopamine hypersensitivity in migraine: role of the apomorphine test. ( Barbanti, P; Brusa, L; Buzzi, MG; Cerbo, R; Fabbrini, G; Lenzi, GL; Roberti, C; Zanette, E, 1997) |
| "Severity of headache, duration of migraine attack and overall efficacy of treatment were amongst the variables assessed in a randomized, double-blind, three-way cross-over comparison of 1 g paracetamol plus either domperidone 30 mg, domperidone 20 mg or placebo, taken at onset of headache." | 2.67 | Domperidone plus paracetamol in the treatment of migraine. ( Bancroft, K; MacGregor, EA; Wilkinson, M, 1993) |
| " Following a previous placebo-controlled trial, a dose-response study was done." | 2.65 | Dopamine blockade with domperidone: bridge between prophylactic and abortive treatment of migraine? A dose-finding study. ( Waelkens, J, 1984) |
| "Patients with migraine exhibited an 18 p." | 2.65 | [Dopaminergic hypersensitivity in migraine: a diagnostic test? (author's transl)]. ( Arné-Bès, MC; Bès, A; Géraud, G; Güell, A, 1982) |
| "Migraine is a typical "women's disease": the fluctuations of sex hormones, in particular estrogens, during woman's reproductive life show a direct and major influence on migraine course." | 2.42 | [Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies]. ( Airola, G; Allais, G; Benedetto, C; Bosio, A; Ciochetto, D; De Lorenzo, C; Mana, O; Quirico, PE; Terzi, MG, 2003) |
| "Nausea and vomiting are common symptoms of migraine, which can be controlled with a variety of anti-emetics including phenothiazines and antihistamines." | 2.41 | Anti-emetics. ( MacGregor, EA, 2001) |
| "Cephalalgias are divided into four syndromes and the most severe of these, migraine, presents several therapeutic applications." | 2.38 | [Therapy of headache]. ( Cavanna, M, 1989) |
| "Migraine burden of migraines with brainstem aura, hemiplegic migraines, and retinal migraine was assessed using the Headache Impact Test-6™ (HIT-6) and the Pediatric Migraine Disability Assessment scale (PedMIDAS)." | 1.56 | Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine. ( Daida, A; Go, S; Ishida, Y; Kashiwagi, Y; Kasuga, A; Kawashima, H; Morichi, S; Morishita, N; Nagao, R; Oana, S; Suganami, Y; Suzuki, S; Takeshita, M; Tomoko, T; Yamanaka, G, 2020) |
| " Therefore, the proposed method is suitable for the routine control of these ingredients in multicomponent dosage forms." | 1.39 | Capillary electrophoretic determination of antimigraine formulations containing caffeine, ergotamine, paracetamol and domperidone or metoclopramide. ( Alshehri, MM; Alzoman, NZ; Elshahed, MS; Maher, HM; Olah, IV; Rizk, MS; Sultan, MA, 2013) |
| "In case of migraine associated with dysmenorrhoea and/or premenstrual tension the management with triphasic hormone proved to be of therapeutic value." | 1.28 | The relation between atypical migraine and multiphasic oral contraceptives. ( Dienes, L; Szigethy, A, 1992) |
| "We tested 22 patients with common migraine (8 men, 7 women in the follicular phase of the menstrual cycle, and 7 women in the luteal phase), and 22 normal subjects adjusted for age, sex and phase of the menstrual cycle." | 1.28 | Tuberoinfundibular dopaminergic tonus in common migraine. ( Alvarez Cermeño, JC; Gutierrez Garcia, JM; Lara Capellan, JI; Riobo Servan, P; Varela Dacosta, C, 1990) |
| "Patients with migraine show a hypersensitivity to dopamine or its agonists." | 1.27 | Pharmacological exploration of dopamine hypersensitivity in migraine patients. ( Bès, A; Bessoles, G; Dupui, P; Géraud, G; Güell, A, 1986) |
| "In a number of patients with complete migraine, migraine attacks can be prevented by taking domperidone, a peripheral dopamine antagonist, at the time of the non-evolutive warning symptoms." | 1.27 | Warning symptoms in migraine: characteristics and therapeutic implications. ( Waelkens, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (50.00) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Yamanaka, G | 1 |
| Go, S | 1 |
| Morichi, S | 1 |
| Takeshita, M | 1 |
| Morishita, N | 1 |
| Suzuki, S | 1 |
| Tomoko, T | 1 |
| Kasuga, A | 1 |
| Daida, A | 1 |
| Ishida, Y | 1 |
| Oana, S | 1 |
| Suganami, Y | 1 |
| Nagao, R | 1 |
| Kashiwagi, Y | 1 |
| Kawashima, H | 1 |
| Israil, A | 1 |
| Ahmed, S | 1 |
| Rahman, KM | 1 |
| Uddin, MJ | 1 |
| Dey, SK | 1 |
| Battacharjee, M | 1 |
| Mondal, G | 1 |
| Ali, MA | 1 |
| Alam, MN | 1 |
| Miah, AH | 1 |
| Uddin, MS | 1 |
| Robbins, NM | 1 |
| Ito, H | 1 |
| Scheinman, MM | 1 |
| Goadsby, PJ | 1 |
| Sultan, MA | 1 |
| Maher, HM | 1 |
| Alzoman, NZ | 1 |
| Alshehri, MM | 1 |
| Rizk, MS | 1 |
| Elshahed, MS | 1 |
| Olah, IV | 1 |
| MacGregor, EA | 2 |
| Allais, G | 1 |
| Bosio, A | 1 |
| Mana, O | 1 |
| Airola, G | 1 |
| Ciochetto, D | 1 |
| Terzi, MG | 1 |
| De Lorenzo, C | 1 |
| Quirico, PE | 1 |
| Benedetto, C | 1 |
| Cheng, FH | 1 |
| Andrews, PL | 1 |
| Moreaux, B | 1 |
| Ngan, MP | 1 |
| Rudd, JA | 1 |
| Sam, TS | 1 |
| Wai, MK | 1 |
| Wan, C | 1 |
| Amery, WK | 1 |
| Waelkens, J | 4 |
| Bès, A | 2 |
| Géraud, G | 2 |
| Güell, A | 2 |
| Arné-Bès, MC | 1 |
| Sicuteri, F | 2 |
| Boccuni, M | 2 |
| Fanciullacci, M | 1 |
| D'Egidio, P | 1 |
| Bonciani, M | 1 |
| Wilkinson, M | 1 |
| Bancroft, K | 1 |
| Cerbo, R | 1 |
| Barbanti, P | 1 |
| Buzzi, MG | 1 |
| Fabbrini, G | 1 |
| Brusa, L | 1 |
| Roberti, C | 1 |
| Zanette, E | 1 |
| Lenzi, GL | 1 |
| Dowson, A | 1 |
| Ball, K | 1 |
| Haworth, D | 1 |
| Szigethy, A | 1 |
| Dienes, L | 1 |
| Varga, A | 1 |
| Lovas, J | 1 |
| Lara Capellan, JI | 1 |
| Varela Dacosta, C | 1 |
| Gutierrez Garcia, JM | 1 |
| Riobo Servan, P | 1 |
| Alvarez Cermeño, JC | 1 |
| Cavanna, M | 1 |
| Cangi, F | 1 |
| Del Bene, E | 1 |
| Fusco, BM | 1 |
| Kis Csitári, I | 1 |
| Champion, MC | 1 |
| Hartnett, M | 1 |
| Yen, M | 1 |
| Murialdo, G | 1 |
| Martignoni, E | 1 |
| De Maria, A | 1 |
| Bonura, ML | 1 |
| Sances, G | 1 |
| Bono, G | 1 |
| Polleri, A | 1 |
| Dupui, P | 1 |
| Bessoles, G | 1 |
| Turner, P | 1 |
| Montastruc, JL | 1 |
| David, J | 1 |
| Rascol, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis: A Single-blind Randomized Controlled Trial[NCT06158230] | Phase 2 | 140 participants (Actual) | Interventional | 2023-03-19 | Active, not recruiting | ||
| Oral Domperidone for Relief of Gastrointestinal Disorders in Patients Who Failed Standard Therapy[NCT00761254] | 42 participants (Actual) | Interventional | 2008-08-31 | Terminated (stopped due to PI withdrew due to increased responsibilities in clinical department.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for domperidone and Migraine Disorders
| Article | Year |
|---|---|
Anti-emetics.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Humans; Metoclopramide; Migraine Disorders; Nausea; | 2001 |
[Migraine during pregnancy and lactation: treatment of the acute attack and non-pharmacological prophylactic strategies].
Topics: Abnormalities, Drug-Induced; Acetaminophen; Acupuncture Points; Acupuncture Therapy; Adult; Analgesi | 2003 |
[Therapy of headache].
Topics: Cluster Headache; Dextropropoxyphene; Dihydroergotamine; Domperidone; Ergotamine; Headache; Humans; | 1989 |
[Dopaminergic disequilibria in hemicrania].
Topics: Animals; Apomorphine; Blood Pressure; Brain; Bromocriptine; Domperidone; Dopamine; Heart Rate; Human | 1985 |
Domperidone, a new dopamine antagonist.
Topics: Administration, Oral; Adult; Child; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Dys | 1986 |
9 trials available for domperidone and Migraine Disorders
| Article | Year |
|---|---|
Efficacy of amitriptyline, pizotifen and propranolol in the prevention of migraine.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Antiemetics; Child; Dompe | 2013 |
Prevention of the last chance: an alternative pharmacologic treatment of migraine.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Domperidone; Double-Blind Method; Female; Humans | 1983 |
Dopamine blockade with domperidone: bridge between prophylactic and abortive treatment of migraine? A dose-finding study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Double-Blind Method; | 1984 |
Domperidone in the prevention of complete classical migraine.
Topics: Clinical Trials as Topic; Domperidone; Double-Blind Method; Humans; Migraine Disorders; Premedicatio | 1982 |
[Dopaminergic hypersensitivity in migraine: a diagnostic test? (author's transl)].
Topics: Cerebrovascular Circulation; Clinical Trials as Topic; Diagnosis, Differential; Domperidone; Dopamin | 1982 |
Domperidone plus paracetamol in the treatment of migraine.
Topics: Acetaminophen; Adolescent; Adult; Aged; Domperidone; Double-Blind Method; Drug Combinations; Female; | 1993 |
Dopamine hypersensitivity in migraine: role of the apomorphine test.
Topics: Adult; Apomorphine; Domperidone; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Re | 1997 |
Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Cross-Over Studies; Domperido | 2000 |
Domperidone, a new dopamine antagonist.
Topics: Administration, Oral; Adult; Child; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Dys | 1986 |
15 other studies available for domperidone and Migraine Disorders
| Article | Year |
|---|---|
Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.
Topics: Adolescent; Brain; Brain Stem; Child; Cost of Illness; Domperidone; Electrocardiography; Electroence | 2020 |
Safety of domperidone in treating nausea associated with dihydroergotamine infusion and headache.
Topics: Adolescent; Adult; Aged; Antiemetics; Dihydroergotamine; Domperidone; Female; Headache; Humans; Male | 2016 |
Capillary electrophoretic determination of antimigraine formulations containing caffeine, ergotamine, paracetamol and domperidone or metoclopramide.
Topics: Acetaminophen; Caffeine; Domperidone; Drug Combinations; Drug Stability; Electrophoresis, Capillary; | 2013 |
[More than six billions Euro costs due to illness days. Migraine therapy counts].
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Cost of Ill | 2003 |
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
Topics: Animals; Antiemetics; Butanols; Capsaicin; Cyclooxygenase Inhibitors; Dihydroergotamine; Diphenhydra | 2005 |
A new nonvascular interpretation of syncopal migraine.
Topics: Adolescent; Adult; Blood Pressure; Bromocriptine; Domperidone; Female; Humans; Hypotension; Male; Mi | 1982 |
The relation between atypical migraine and multiphasic oral contraceptives.
Topics: Adult; Contraceptives, Oral; Diclofenac; Domperidone; Drug Evaluation; Female; Humans; Menstruation; | 1992 |
Some possible gynaecological indications for peripheral antidopamine therapy.
Topics: Adult; Climacteric; Domperidone; Drug Evaluation; Dyspepsia; Female; Gastrointestinal Diseases; Huma | 1992 |
Tuberoinfundibular dopaminergic tonus in common migraine.
Topics: Domperidone; Dopamine; Female; Humans; Male; Migraine Disorders; Pituitary Gland; Prolactin | 1990 |
Use of peripheral dopamine receptor antagonist in gynaecology in certain borderline cases.
Topics: Climacteric; Domperidone; Dyspepsia; Female; Gastrointestinal Diseases; Humans; Migraine Disorders; | 1987 |
Changes in the dopaminergic control of prolactin secretion and in ovarian steroids in migraine.
Topics: Adult; Domperidone; Dopamine; Estradiol; Female; Follicular Phase; Humans; Lisuride; Luteal Phase; M | 1986 |
Pharmacological exploration of dopamine hypersensitivity in migraine patients.
Topics: Cerebrovascular Circulation; Domperidone; Dopamine; Headache; Humans; Hypotension; Migraine Disorder | 1986 |
Adverse reactions to drugs in migraine: some recent reports.
Topics: Domperidone; Ergotamine; Humans; Metoclopramide; Migraine Disorders | 1985 |
Does the piribedil test permit predicting the efficacy of domperidone, a dopaminergic antagonist, in the treatment of migraine?
Topics: Adult; Domperidone; Dopamine Antagonists; Female; Forecasting; Humans; Male; Middle Aged; Migraine D | 1985 |
Warning symptoms in migraine: characteristics and therapeutic implications.
Topics: Adolescent; Adult; Aged; Cisapride; Domperidone; Female; Humans; Male; Middle Aged; Migraine Disorde | 1985 |