domperidone has been researched along with Long QT Syndrome in 20 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders." | 6.46 | Domperidone and long QT syndrome. ( Giorgi, G; Rossi, M, 2010) |
| "Domperidone is an effective antiemetic used worldwide, but there have been reports of possible cardiotoxicity." | 5.72 | Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms. ( Bustamante-Bernal, M; Espino, K; Gajendran, M; Gonzalez, Z; McCallum, R; Sarosiek, I; Siddiqui, T; Waterhouse, N; Woods, K, 2022) |
| "A search of two bibliographic databases, the European Medicines Agency (EMA) website, Micromedex, Lexicomp and reference texts was undertaken for domperidone related reports of QT prolongation, cardiac arrhythmias and/or SCD." | 4.91 | Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations. ( Buffery, PJ; Strother, RM, 2015) |
| "Domperidone is a dopamine receptor antagonist used for the treatment of gastroparesis." | 3.91 | Effect of Chronic Domperidone Use on QT Interval: A Large Single Center Study. ( Bhuta, R; Cooper, J; Field, J; Malik, Z; Parkman, HP; Schey, R; Wasilewski, M, 2019) |
| "Domperidone, a peripheral D2 dopamine receptor antagonist, has efficacy for treatment of nausea, dyspepsia, and gastroparesis." | 3.85 | Domperidone is Commonly Prescribed With QT-Interacting Drugs: Review of a Community-based Practice and a Postmarketing Adverse Drug Event Reporting Database. ( Alexoff, A; Ehrenpreis, ED; Roginsky, G; Smith, DG, 2017) |
| "Observational retrospective studies have linked domperidone and prolonged QT interval, ventricular arrhythmias and risk of sudden death." | 3.85 | [Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database]. ( Auffret, M; Béné, J; Gautier, S; Rochoy, M, 2017) |
| "To determine whether oral domperidone is associated with QT interval prolongation and ventricular arrhythmia and to identify factors that can influence these effects." | 3.74 | Effect of domperidone on QT interval in neonates. ( Djeddi, D; Kongolo, G; Lefaix, C; Léké, A; Mounard, J, 2008) |
| "To assess the steady-state pharmacokinetic and QT(c) effects of domperidone and ketoconazole, given alone and together." | 2.77 | Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study. ( Baisley, KJ; Boyce, MJ; Warrington, SJ, 2012) |
| "Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders." | 2.46 | Domperidone and long QT syndrome. ( Giorgi, G; Rossi, M, 2010) |
| "Domperidone is an effective antiemetic used worldwide, but there have been reports of possible cardiotoxicity." | 1.72 | Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms. ( Bustamante-Bernal, M; Espino, K; Gajendran, M; Gonzalez, Z; McCallum, R; Sarosiek, I; Siddiqui, T; Waterhouse, N; Woods, K, 2022) |
| "Verapamil treatment augmented prolongation of MAPD( 90) caused by dofetilide or domperidone (P < ." | 1.35 | Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs. ( Hreiche, R; Morissette, P; Turgeon, J; Zakrzewski-Jakubiak, H, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Poluzzi, E | 1 |
| De Ponti, F | 1 |
| Recanatini, M | 1 |
| Wang, F | 1 |
| Nie, J | 1 |
| Yang, L | 1 |
| Yang, Z | 1 |
| Xu, L | 1 |
| Wang, L | 1 |
| Liao, H | 1 |
| Li, M | 1 |
| Wang, P | 1 |
| Li, G | 1 |
| Li, H | 1 |
| Woods, K | 1 |
| Gajendran, M | 1 |
| Gonzalez, Z | 1 |
| Bustamante-Bernal, M | 1 |
| Sarosiek, I | 1 |
| Espino, K | 1 |
| Waterhouse, N | 1 |
| Siddiqui, T | 1 |
| McCallum, R | 1 |
| Kamath, A | 1 |
| Rai, KM | 1 |
| Shreyas, R | 1 |
| Saxena, PUP | 1 |
| Banerjee, S | 1 |
| Berger, F | 1 |
| Saâïd, S | 1 |
| van Gelder, T | 1 |
| Stricker, B | 1 |
| Becker, M | 1 |
| van den Bemt, P | 1 |
| Field, J | 1 |
| Wasilewski, M | 1 |
| Bhuta, R | 1 |
| Malik, Z | 1 |
| Cooper, J | 1 |
| Parkman, HP | 1 |
| Schey, R | 1 |
| Caraballo, L | 1 |
| Molina, G | 1 |
| Weitz, D | 1 |
| Piskulic, L | 1 |
| Avila, A | 1 |
| Marzi, M | 1 |
| Buffery, PJ | 1 |
| Strother, RM | 1 |
| Ioannou, A | 1 |
| Jain, A | 1 |
| Kassianos, G | 1 |
| Missouris, C | 1 |
| Ehrenpreis, ED | 1 |
| Roginsky, G | 1 |
| Alexoff, A | 1 |
| Smith, DG | 1 |
| Rochoy, M | 1 |
| Auffret, M | 1 |
| Béné, J | 1 |
| Gautier, S | 1 |
| Djeddi, D | 1 |
| Kongolo, G | 1 |
| Lefaix, C | 1 |
| Mounard, J | 1 |
| Léké, A | 1 |
| Collins, KK | 1 |
| Sondheimer, JM | 1 |
| Hreiche, R | 1 |
| Morissette, P | 1 |
| Zakrzewski-Jakubiak, H | 1 |
| Turgeon, J | 1 |
| Rossi, M | 1 |
| Giorgi, G | 1 |
| Boyce, MJ | 1 |
| Baisley, KJ | 1 |
| Warrington, SJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology[NCT03221855] | Early Phase 1 | 30 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for domperidone and Long QT Syndrome
| Article | Year |
|---|---|
[Proarrhythmic effects of domperidone in infants: a systematic review].
Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Cisapride; Contraindications; Cytochrome P-450 CYP3A; Dom | 2014 |
Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations.
Topics: Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Death, Sudde | 2015 |
Domperidone and long QT syndrome.
Topics: Adult; Animals; Arrhythmias, Cardiac; Child; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonis | 2010 |
2 trials available for domperidone and Long QT Syndrome
| Article | Year |
|---|---|
Four-Way Crossover Phase 1 Thorough QT Study to Assess Cardiac Safety of Domperidone and Consideration for Design and Conduct of QT/QTc Study in China.
Topics: Domperidone; Heart; Humans; Long QT Syndrome; Moxifloxacin | 2022 |
Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study.
Topics: 14-alpha Demethylase Inhibitors; Adolescent; Adult; Analysis of Variance; Area Under Curve; Arrhythm | 2012 |
15 other studies available for domperidone and Long QT Syndrome
| Article | Year |
|---|---|
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go- | 2002 |
Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms.
Topics: Domperidone; Female; Gastroparesis; Humans; Long QT Syndrome; Male; Middle Aged; Retrospective Studi | 2022 |
Effect of domperidone, ondansetron, olanzapine-containing antiemetic regimen on QT
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Agents; Domperidone; Drug Co | 2021 |
Media attention regarding sudden cardiac death associated with domperidone use does not affect in hospital ECG recording.
Topics: Adult; Aged; Antiemetics; Cohort Studies; Death, Sudden, Cardiac; Domperidone; Drug Prescriptions; D | 2017 |
Effect of Chronic Domperidone Use on QT Interval: A Large Single Center Study.
Topics: Adult; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrocardiography; Fem | 2019 |
Survey of the use of domperidone and the association with QTc prolongation in general practice.
Topics: Aged; Domperidone; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; | 2016 |
Domperidone is Commonly Prescribed With QT-Interacting Drugs: Review of a Community-based Practice and a Postmarketing Adverse Drug Event Reporting Database.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antiemetics; Domperidone; D | 2017 |
[Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Car | 2017 |
Domperidone and sudden death. Cardiac rhythm disorders: QT interval prolongation.
Topics: Antiemetics; Arrhythmias, Cardiac; Canada; Death, Sudden, Cardiac; Domperidone; Humans; Long QT Synd | 2008 |
Effect of domperidone on QT interval in neonates.
Topics: Administration, Oral; Arrhythmias, Cardiac; Domperidone; Dopamine Antagonists; Drug-Related Side Eff | 2008 |
Domperidone-induced QT prolongation: add another drug to the list.
Topics: Animals; Cisapride; Domperidone; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactio | 2008 |
Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Domperidon | 2009 |
Domperidone: QT prolongation in infants.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; France; Gastroesophageal Reflux; Humans; Infant; Inf | 2011 |
Interaction between ketoconazole and domperidone and the risk of QT prolongation--important safety information.
Topics: Antiemetics; Antifungal Agents; Domperidone; Drug Interactions; Humans; Ketoconazole; Long QT Syndro | 2006 |
Domperidone and sudden death.
Topics: Adult; Antiemetics; Brazil; Clinical Trials as Topic; Death, Sudden, Cardiac; Domperidone; Drug Appr | 2006 |