domperidone has been researched along with Hypoxia in 46 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have analyzed a conditioned avoidance response (CAR) in rats, under both normoxia and hypobaric hypoxia (300 torr), to try to elucidate the mechanism of apomorphine's protective effect against hypoxia." | 7.66 | Avoidance learning and mechanism of the protective effect of apomorphine against hypoxia. ( Boismare, F; Moore, N; Raoult, JP; Saligaut, C, 1981) |
| " Exposure to moderate and severe hypoxia as well as to hyperoxia and injection of domperidone, a potent peripheral ventilatory stimulant, revealed that the presence of transgenic or rhEpo extensively increased the hypoxic ventilatory response in female mice compared with their corresponding male siblings." | 3.75 | Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin. ( Gassmann, M; Lundby, C; Soliz, J; Soulage, C; Thomsen, JJ, 2009) |
| " Peripheral chemoreceptor effects on ventilation were evaluated by exposing animals to hyperoxia (Dejours test) and domperidone, a peripheral ventilatory stimulant drug directly affecting the carotid sinus nerve discharge." | 3.74 | Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. ( Borter, E; Gassmann, M; Soliz, J; Soulage, C; van Patot, MT, 2008) |
| "05) and gave rise, following post-hyperventilation apnea, to an increased incidence of PB (14% vs." | 3.74 | Increased peripheral chemosensitivity via dopaminergic manipulation promotes respiratory instability in lambs. ( Berger, PJ; Brodecky, V; Edwards, BA; Sands, SA; Skuza, EM; Stockx, EM; Wilkinson, MH, 2008) |
| " In ovariectomized female rats raised at sea level, domperidone, a peripheral D2-receptor antagonist, increased ventilation in normoxia (minute ventilation = +55%) and acute hypoxia (+32%)." | 3.71 | Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats. ( Favier, R; Joseph, V; Pequignot, J; Pequignot, JM; Soliz, J; Soria, R; Spielvogel, H, 2002) |
| " Substantially less reflex hyperventilation was evoked in capsaicin-treated rats by the peripheral chemoreceptor stimulants hypoxia and sodium cyanide, in comparison with the controls, and domperidone did not increase the responsiveness." | 3.67 | Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin. ( McQueen, DS; Mir, AK, 1984) |
| " In view of this we studied the effect of apomorphine, specific antagonists of dopamine receptors SCH 23390 (D1), sulpiride and domperidone (D2), and cis(z)-flupentixol (D1 + D2) on the typical ventilatory response to hypoxia in neonatal rabbit pups." | 3.67 | A possible dopaminergic pathway mediating hypoxic depression in neonatal rabbits. ( Lagercrantz, H; Srinivasan, M; Yamamoto, Y, 1989) |
| " In one series, we simultaneously measured carotid chemoreceptor and ventilatory responses to hypoxia and hypercapnia before and after a saturation dose of intravenous domperidone, a peripheral dopamine (D2) receptor antagonist." | 3.67 | Peripheral and central dopamine receptors in respiratory control. ( Hsiao, C; Lahiri, S; Mokashi, A, 1989) |
| "The effects of apomorphine on survival time of mice during lethal anoxic hypoxia were studied." | 3.67 | Survival time in hypoxic mice: differentiation between apomorphine-induced hypothermia and antihypoxic properties. ( Boismare, F; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1986) |
| "The study of apomorphine's interaction with three dopaminergic antagonists (domperidone, sulpiride and pimozide) is an attempt to characterize the dopaminergic receptors involved in the dopaminergic agonist-induced protection against hypobaric hypoxia." | 3.66 | Modification by sulpiride, pimozide, or domperidone of apomorphine's effects on learning in hypoxic rats. ( Boismare, F; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1983) |
| "We have analyzed a conditioned avoidance response (CAR) in rats, under both normoxia and hypobaric hypoxia (300 torr), to try to elucidate the mechanism of apomorphine's protective effect against hypoxia." | 3.66 | Avoidance learning and mechanism of the protective effect of apomorphine against hypoxia. ( Boismare, F; Moore, N; Raoult, JP; Saligaut, C, 1981) |
| "Domperidone treatment in intact animals evoked a significant increase in normoxic tidal volume, while haloperidol potentiated tidal volume increase in response to hypoxia." | 1.43 | Hypoxic ventilatory response after dopamine D2 receptor blockade in unilateral rat model of Parkinson's disease. ( Andrzejewski, K; Budzińska, K; Kaczyńska, K; Zaremba, M, 2016) |
| "Domperidone caused an increase in CSN activity at all O2 levels in adults (P < 0." | 1.29 | Effects of domperidone on neonatal and adult carotid chemoreceptors in the cat. ( Bamford, OS; Carroll, JL; Fitzgerald, RS; Sterni, LM; Tomares, SM, 1994) |
| "Domperidone treated animals had a significantly greater acute ventilatory response to hypoxia followed by a lower rate of progressive hyperventilation in this period." | 1.27 | Dopamine blockade alters ventilatory acclimatization to hypoxia in goats. ( Bisgard, GE; Daristotle, L; Forster, HV; Kressin, NA; Nielsen, AM; Smith, CA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (30.43) | 18.7374 |
| 1990's | 17 (36.96) | 18.2507 |
| 2000's | 12 (26.09) | 29.6817 |
| 2010's | 3 (6.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrzejewski, K | 1 |
| Budzińska, K | 1 |
| Zaremba, M | 1 |
| Kaczyńska, K | 1 |
| Soliz, J | 4 |
| Soulage, C | 3 |
| Borter, E | 1 |
| van Patot, MT | 1 |
| Gassmann, M | 3 |
| Edwards, BA | 2 |
| Sands, SA | 2 |
| Skuza, EM | 1 |
| Stockx, EM | 1 |
| Brodecky, V | 1 |
| Wilkinson, MH | 1 |
| Berger, PJ | 2 |
| Thomsen, JJ | 1 |
| Lundby, C | 1 |
| Nemati, S | 1 |
| Wellman, A | 1 |
| Verghese, GC | 1 |
| Malhotra, A | 1 |
| Butler, JP | 1 |
| Julien, CA | 1 |
| Joseph, V | 2 |
| Bairam, A | 1 |
| Gamboa, J | 1 |
| Macarlupú, JL | 1 |
| Rivera-Chira, M | 1 |
| Monge-C, C | 1 |
| León-Velarde, F | 1 |
| Kim, DK | 1 |
| Prabhakar, NR | 1 |
| Kumar, GK | 1 |
| Subramanian, S | 1 |
| Dostal, J | 1 |
| Erokwu, B | 1 |
| Han, F | 1 |
| Dick, TE | 1 |
| Strohl, KP | 1 |
| Hermann, DM | 1 |
| Schlenker, EH | 1 |
| Kirby, GC | 1 |
| McQueen, DS | 4 |
| Mir, AK | 2 |
| Brash, HM | 1 |
| Nahorski, SR | 1 |
| Saligaut, C | 3 |
| Moore, N | 3 |
| Chretien, P | 2 |
| Daoust, M | 2 |
| Boismare, F | 3 |
| Raoult, JP | 1 |
| Tatsumi, K | 3 |
| Pickett, CK | 3 |
| Weil, JV | 3 |
| Tomares, SM | 2 |
| Bamford, OS | 2 |
| Sterni, LM | 2 |
| Fitzgerald, RS | 2 |
| Carroll, JL | 2 |
| Iturriaga, R | 2 |
| Larraín, C | 2 |
| Zapata, P | 2 |
| Bee, D | 3 |
| Wright, C | 1 |
| Pallot, D | 1 |
| Lagneaux, D | 1 |
| Pallot, DJ | 1 |
| Janssen, PL | 1 |
| O'Halloran, KD | 1 |
| Pizarro, J | 2 |
| Dwinell, MR | 1 |
| Bisgard, GE | 4 |
| Walsh, TS | 1 |
| Foo, IT | 1 |
| Drummond, GB | 1 |
| Warren, PM | 1 |
| Pedersen, ME | 2 |
| Dorrington, KL | 3 |
| Robbins, PA | 3 |
| Osanai, S | 1 |
| Akiba, Y | 1 |
| Fujiuchi, S | 1 |
| Nakano, H | 2 |
| Matsumoto, H | 1 |
| Ohsaki, Y | 1 |
| Kikuchi, K | 1 |
| Huey, KA | 1 |
| Brown, IP | 1 |
| Jordan, MC | 1 |
| Powell, FL | 1 |
| Lee, SD | 1 |
| Farkas, GA | 1 |
| Soria, R | 1 |
| Pequignot, J | 1 |
| Favier, R | 1 |
| Spielvogel, H | 1 |
| Pequignot, JM | 1 |
| Güner, I | 1 |
| Yelmen, N | 1 |
| Sahin, G | 1 |
| Oruç, T | 1 |
| Warner, MM | 1 |
| Ryan, M | 1 |
| Mitchell, GS | 2 |
| Bascom, DA | 1 |
| Clement, ID | 1 |
| Evrard, Y | 1 |
| Gordon, BH | 1 |
| Campbell, DB | 1 |
| Wach, RA | 1 |
| Barer, GR | 1 |
| Schaefer, SL | 1 |
| Srinivasan, M | 1 |
| Lagercrantz, H | 1 |
| Yamamoto, Y | 1 |
| Hsiao, C | 1 |
| Lahiri, S | 1 |
| Mokashi, A | 1 |
| Kressin, NA | 2 |
| Nielsen, AM | 2 |
| Daristotle, L | 1 |
| Smith, CA | 1 |
| Forster, HV | 1 |
| Laravuso, R | 1 |
| Delpierre, S | 1 |
| Peyrot, J | 1 |
| Guillot, C | 1 |
| Grimaud, C | 1 |
1 review available for domperidone and Hypoxia
| Article | Year |
|---|---|
Domperidone as a tool to assess the role of dopamine within carotid body chemoreception.
Topics: Action Potentials; Animals; Carbon Dioxide; Carotid Body; Cats; Cell Hypoxia; Domperidone; Dopamine; | 1996 |
3 trials available for domperidone and Hypoxia
| Article | Year |
|---|---|
Influence of dose of domperidone on the acute ventilatory response to hypoxia in humans.
Topics: Adult; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Double-Blind Method; Hum | 1998 |
Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia.
Topics: Acclimatization; Adult; Altitude; Carbon Dioxide; Domperidone; Dopamine; Dopamine Antagonists; Femal | 1999 |
Depression of peripheral chemosensitivity by a dopaminergic mechanism in patients with obstructive sleep apnoea syndrome.
Topics: Adult; Aged; Chemoreceptor Cells; Domperidone; Dopamine; Dopamine Antagonists; Double-Blind Method; | 1999 |
42 other studies available for domperidone and Hypoxia
| Article | Year |
|---|---|
Hypoxic ventilatory response after dopamine D2 receptor blockade in unilateral rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Disease Mode | 2016 |
Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice.
Topics: Acclimatization; Acute Disease; Animals; Body Temperature; Carotid Body; Chronic Disease; Disease Mo | 2008 |
Increased peripheral chemosensitivity via dopaminergic manipulation promotes respiratory instability in lambs.
Topics: Animals; Animals, Newborn; Apnea; Carbon Dioxide; Carotid Body; Chemoreceptor Cells; Domperidone; Do | 2008 |
Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin.
Topics: Adaptation, Physiological; Adult; Animals; Brain Stem; Catecholamines; Disease Models, Animal; Dompe | 2009 |
Model-based characterization of ventilatory stability using spontaneous breathing.
Topics: Animals; Animals, Newborn; Apnea; Carbon Dioxide; Carotid Body; Domperidone; Dopamine Antagonists; D | 2011 |
Alteration of carotid body chemoreflexes after neonatal intermittent hypoxia and caffeine treatment in rat pups.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Apnea; Body Temperature; Body Weight; | 2011 |
Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats.
Topics: Animals; Chronic Disease; Domperidone; Dopamine Antagonists; Hemoglobins; Hypoxia; Male; Polycythemi | 2003 |
Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Carotid Body; Domperidone; Dopamine Antagoni | 2004 |
Domperidone and ventilatory behavior: Sprague-Dawley versus Brown Norway rats.
Topics: Animals; Behavior, Animal; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Enzy | 2007 |
Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin.
Topics: Acclimatization; Animals; Domperidone; Dopamine Antagonists; Erythropoietin; Female; Gene Expression | 2007 |
In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia.
Topics: Animals; Body Temperature; Carbon Dioxide; Carotid Body; Cricetinae; Disease Models, Animal; Domperi | 2007 |
Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine.
Topics: Action Potentials; Animals; Carotid Body; Cats; Chemoreceptor Cells; Domperidone; Dopamine; Electrop | 1984 |
Increased sensitivity of rabbit carotid body chemoreceptors to dopamine after chronic treatment with domperidone.
Topics: Animals; Binding Sites; Carotid Body; Chemoreceptor Cells; Domperidone; Dopamine; Electrophysiology; | 1984 |
Changes in carotid body amine levels and effects of dopamine on respiration in rats treated neonatally with capsaicin.
Topics: Animals; Animals, Newborn; Biogenic Amines; Capsaicin; Carotid Body; Denervation; Domperidone; Dopam | 1984 |
Modification by sulpiride, pimozide, or domperidone of apomorphine's effects on learning in hypoxic rats.
Topics: Animals; Apomorphine; Atmosphere Exposure Chambers; Avoidance Learning; Domperidone; Female; Hypoxia | 1983 |
Avoidance learning and mechanism of the protective effect of apomorphine against hypoxia.
Topics: Animals; Apomorphine; Atmospheric Pressure; Avoidance Learning; Benzimidazoles; Domperidone; Female; | 1981 |
Possible role of dopamine in ventilatory acclimatization to high altitude.
Topics: Acclimatization; Altitude; Animals; Body Weight; Cats; Domperidone; Dopamine; Female; Hypercapnia; H | 1995 |
Effects of domperidone on neonatal and adult carotid chemoreceptors in the cat.
Topics: Animals; Carbon Dioxide; Carotid Body; Carotid Sinus; Cats; Domperidone; Dopamine Antagonists; Elect | 1994 |
Effects of dopaminergic blockade upon carotid chemosensory activity and its hypoxia-induced excitation.
Topics: Animals; Blood Pressure; Carotid Sinus; Cats; Chemoreceptor Cells; Domperidone; Dopamine D2 Receptor | 1994 |
Attenuation of the hypoxic ventilatory response in awake rabbit pups; possible role of dopamine.
Topics: Animals; Domperidone; Dopamine; Female; Hypoxia; Male; Rabbits; Reference Values; Respiration; Wakef | 1994 |
The role of endogenous dopamine as an inhibitory neuromodulator in neonatal and adult carotid bodies.
Topics: Aging; Animals; Animals, Newborn; Carotid Body; Cats; Domperidone; Dopamine; Female; Hypoxia; Male; | 1994 |
Ventilatory responses to brief hypoxic stimuli after simulated altitude exposure in rat.
Topics: Acclimatization; Altitude; Animals; Chemoreceptor Cells; Domperidone; Dopamine; Dopamine D2 Receptor | 1994 |
Decreased carotid body hypoxic sensitivity in chronic hypoxia: role of dopamine.
Topics: Anesthesia; Animals; Carotid Body; Carotid Sinus; Cats; Chronic Disease; Domperidone; Dopamine; Dopa | 1995 |
Acute hypoxic ventilation, carotid body cell division, and dopamine content during early hypoxia in rats.
Topics: Acute Disease; Animals; Autoradiography; Carotid Body; Cell Division; Domperidone; Dopamine; Dopamin | 1995 |
Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats.
Topics: Acclimatization; Animals; Carotid Body; Chemoreceptor Cells; Domperidone; Female; Goats; Hypoxia; Ma | 1998 |
Modulation of ventilatory sensitivity to hypoxia by dopamine and domperidone before and after prolonged exposure to hypoxia in humans.
Topics: Animals; Cardiotonic Agents; Domperidone; Dopamine; Dopamine Antagonists; Humans; Hypoxia; Pulmonary | 1998 |
Changes in dopamine D(2)-receptor modulation of the hypoxic ventilatory response with chronic hypoxia.
Topics: Animals; Carbon Dioxide; Carotid Body; Central Nervous System; Domperidone; Dopamine Antagonists; Do | 2000 |
Dopaminergic modulation of ventilation in obese Zucker rats.
Topics: Animals; Body Temperature; Domperidone; Dopamine; Dopamine Antagonists; Haloperidol; Hypercapnia; Hy | 2002 |
Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats.
Topics: Acclimatization; Altitude; Animals; Cardiomegaly; Carotid Body; Catecholamines; Domperidone; Dopamin | 2002 |
The effect of intracerebroventricular dopamine administration on the respiratory response to hypoxia.
Topics: Animals; Cerebrovascular Circulation; Domperidone; Dopamine; Dopamine Antagonists; Haloperidol; Hypo | 2002 |
Intracarotid norepinephrine infusions inhibit ventilation in goats.
Topics: Animals; Carotid Arteries; Carotid Body; Domperidone; Dopamine; Goats; Hypoxia; Injections, Intra-Ar | 1992 |
Effects of haloperidol and domperidone on ventilatory roll off during sustained hypoxia in cats.
Topics: Animals; Carotid Sinus; Cats; Domperidone; Dopamine Antagonists; Electrophysiology; Female; Haloperi | 1992 |
Effects of dopamine and domperidone on ventilation during isocapnic hypoxia in humans.
Topics: Adult; Almitrine; Domperidone; Dopamine; Female; Humans; Hypoxia; Male; Random Allocation; Respirati | 1991 |
Ganglioglomerular nerves influence responsiveness of cat carotid body chemoreceptors to almitrine.
Topics: Action Potentials; Adrenergic Fibers; Almitrine; Animals; Carotid Body; Cats; Chemoreceptor Cells; D | 1989 |
Dopamine and ventilatory effects of hypoxia and almitrine in chronically hypoxic rats.
Topics: Almitrine; Animals; Central Nervous System Stimulants; Chronic Disease; Domperidone; Dopamine Antago | 1989 |
Ventilatory control during exercise with peripheral chemoreceptor stimulation: hypoxia vs. domperidone.
Topics: Animals; Carotid Body; Domperidone; Female; Goats; Hypoxia; Physical Exertion; Respiration | 1989 |
A possible dopaminergic pathway mediating hypoxic depression in neonatal rabbits.
Topics: Animals; Animals, Newborn; Apomorphine; Benzazepines; Decerebrate State; Domperidone; Dopamine Antag | 1989 |
Peripheral and central dopamine receptors in respiratory control.
Topics: Animals; Carotid Body; Cats; Domperidone; Dopamine; Female; Haloperidol; Hypercapnia; Hypoxia; Recep | 1989 |
Dopamine blockade alters ventilatory acclimatization to hypoxia in goats.
Topics: Acclimatization; Animals; Blood Gas Analysis; Carotid Body; Domperidone; Dopamine Antagonists; Femal | 1987 |
Survival time in hypoxic mice: differentiation between apomorphine-induced hypothermia and antihypoxic properties.
Topics: Animals; Apomorphine; Body Temperature; Domperidone; Drug Interactions; Female; Haloperidol; Hypoxia | 1986 |
Domperidone-induced potentiation of ventilatory responses in awake goats.
Topics: Animals; Carotid Body; Denervation; Domperidone; Dopamine Antagonists; Goats; Hypercapnia; Hypoxia; | 1986 |
Ventilatory effects of domperidone, a new dopamine antagonist, in anaesthetized rabbits.
Topics: Anesthesia; Animals; Blood Gas Analysis; Carbon Dioxide; Domperidone; Dopamine Antagonists; Heart Ra | 1985 |