domperidone has been researched along with Hypothyroidism in 7 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The thyrotrophin (TSH) and prolactin (Prl) releasing effects of domperidone, a recently developed antidopaminergic drug which does not cross the blood-brain barrier, were investigated in 8 women affected by primary hypothyroidism, and were compared to those elicited by another antidopaminergic drug, sulpiride." | 3.66 | Increased thyrotrophin and prolactin secretion induced by domperidone in hypothyroid subjects. ( Amoroso, A; Camanni, F; Massara, F; Molinatti, GM; Müller, EE, 1981) |
| "Domperidone, an extracerebral dopamine receptor antagonist, was given im to 12 normal subjects and to a group of patients with subclinical hypothyroidism to study its effect on PRL and TSH secretion." | 3.66 | Domperidone, an extracerebral inhibitor of dopamine receptors, stimulates thyrotropin and prolactin release in man. ( Delitala, G; Devilla, L; Lotti, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holdaway, IM | 1 |
| Evans, MC | 1 |
| Sheehan, A | 1 |
| Ibbertson, HK | 1 |
| Massara, F | 1 |
| Camanni, F | 1 |
| Amoroso, A | 1 |
| Molinatti, GM | 1 |
| Müller, EE | 1 |
| Delitala, G | 2 |
| Devilla, L | 2 |
| Canessa, A | 1 |
| D'Asta, F | 1 |
| Kamijo, K | 1 |
| Kato, T | 1 |
| Saito, A | 1 |
| Suzuki, M | 1 |
| Yachi, A | 1 |
| Lotti, G | 1 |
| Pourmand, M | 1 |
| Rodriguez-Arnao, MD | 1 |
| Weightman, DR | 1 |
| Hall, R | 1 |
| Cook, DB | 1 |
| Lewis, M | 1 |
| Scanlon, MF | 1 |
| Marcondes, JA | 1 |
| Santomauro, AT | 1 |
| Minanni, SL | 1 |
| Wajchenberg, BL | 1 |
7 other studies available for domperidone and Hypothyroidism
| Article | Year |
|---|---|
Low thyroxine levels in some hyperprolactinemic patients due to dopaminergic suppression of thyrotropin.
Topics: Adult; Domperidone; Dopamine; Female; Humans; Hypothalamus; Hypothyroidism; Male; Metoclopramide; Mi | 1984 |
Increased thyrotrophin and prolactin secretion induced by domperidone in hypothyroid subjects.
Topics: Adolescent; Adult; Aged; Benzimidazoles; Domperidone; Female; Humans; Hypothyroidism; Middle Aged; P | 1981 |
On the role of dopamine receptors in the central regulation of human TSH.
Topics: Adult; Domperidone; Dopamine; Female; Haloperidol; Humans; Hypothalamus; Hypothyroidism; Male; Middl | 1981 |
Evidence of sex difference in dopaminergic modulation of serum TSH secretion in primary hypothyroidism.
Topics: Adult; Domperidone; Estradiol; Female; Humans; Hypothyroidism; Male; Middle Aged; Receptors, Dopamin | 1981 |
Domperidone, an extracerebral inhibitor of dopamine receptors, stimulates thyrotropin and prolactin release in man.
Topics: Adult; Benzimidazoles; Domperidone; Female; Humans; Hypothyroidism; Kinetics; Male; Piperidines; Pro | 1980 |
Domperidone: a novel agent for the investigation of anterior pituitary function and control in man.
Topics: Autoimmune Diseases; Benzimidazoles; Domperidone; Dopamine Antagonists; Hypothyroidism; Piperidines; | 1980 |
Dissociated response of thyrotropin and prolactin to dopamine receptor blockade with domperidone in hypothyroid subjects.
Topics: Adult; Domperidone; Dopamine Antagonists; Female; Humans; Hypothyroidism; Prolactin; Receptors, Dopa | 1991 |