domperidone has been researched along with Hypotension, Orthostatic in 14 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In three patients with orthostatic hypotension successfully treated by the peripheral dopaminergic antagonist domperidone 60 mg/day, the subsequent introduction of verapamil 240 mg/day did not modify the standing-induced decrease in systolic blood pressure: 46." | 5.27 | Hypertension with orthostatic hypotension: interest of verapamil. ( Chamontin, BF; Montastruc, JL; Salvador, MJ, 1987) |
| " The included RCTs were small (total of 28 participants in RCTs), short term (two to three weeks), only examined fludrocortisone for orthostatic hypotension in people with two conditions (diabetes and Parkinson disease), and had variable risk of bias (two had unclear risk of bias and one had low risk of bias)." | 5.12 | Fludrocortisone for orthostatic hypotension. ( Ansari, Y; Chung, KA; Gibbons, CH; Helfand, M; Peterson, K; Raj, SR; Veazie, S, 2021) |
| "There is limited evidence for the treatment of orthostatic hypotension in idiopathic Parkinson's disease." | 2.73 | Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease. ( Henderson, RD; O'Maley, K; O'Sullivan, JD; Schoffer, KL, 2007) |
| "Domperidone is a proposed treatment of orthostatic hypotension (OH) in Parkinson's disease (PD)." | 2.55 | Domperidone for Hypotension in Parkinson's Disease: A Systematic Review. ( Bacchi, S; Chim, I; Kramer, P; Postuma, RB, 2017) |
| "Both hypertension and orthostatic hypotension (OH) are strongly age-associated and are common management problems in older people." | 2.55 | Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension. ( Anpalahan, M; Chisholm, P, 2017) |
| "In three patients with orthostatic hypotension successfully treated by the peripheral dopaminergic antagonist domperidone 60 mg/day, the subsequent introduction of verapamil 240 mg/day did not modify the standing-induced decrease in systolic blood pressure: 46." | 1.27 | Hypertension with orthostatic hypotension: interest of verapamil. ( Chamontin, BF; Montastruc, JL; Salvador, MJ, 1987) |
| " Administration of domperidone for 3 days reduced the falls in creatinine clearance and the urinary excretion of sodium and potassium induced by UP but did not alter the blood pressure and aldosterone dose-response curves to angiotensin II." | 1.27 | Peripheral dopaminergic blockade for the treatment of diabetic orthostatic hypotension. ( Andriolo, A; Chacra, AR; Lopes de Faria, SR; Ribeiro, AB; Zanella, MT, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Veazie, S | 1 |
| Peterson, K | 1 |
| Ansari, Y | 1 |
| Chung, KA | 1 |
| Gibbons, CH | 1 |
| Raj, SR | 1 |
| Helfand, M | 1 |
| Bacchi, S | 1 |
| Chim, I | 1 |
| Kramer, P | 1 |
| Postuma, RB | 1 |
| Jones, J | 1 |
| Kuritzky, L | 1 |
| Chisholm, P | 1 |
| Anpalahan, M | 1 |
| Schoffer, KL | 1 |
| Henderson, RD | 1 |
| O'Maley, K | 1 |
| O'Sullivan, JD | 1 |
| Lang, AE | 1 |
| Chamontin, BF | 1 |
| Montastruc, JL | 4 |
| Salvador, MJ | 1 |
| Chamontin, B | 2 |
| Villeneuve, A | 1 |
| Berlan, M | 1 |
| Salvador, M | 1 |
| Lopes de Faria, SR | 1 |
| Zanella, MT | 1 |
| Andriolo, A | 1 |
| Ribeiro, AB | 1 |
| Chacra, AR | 1 |
| Micheli, F | 1 |
| Gatto, E | 1 |
| Fernández Pardal, M | 1 |
| Paradiso, G | 1 |
| Gaillard, G | 1 |
| Rascol, O | 1 |
| Pollak, P | 1 |
| Mallaret, M | 1 |
| Gaio, JM | 1 |
| Hommel, M | 1 |
| Perret, J | 1 |
| Destee, A | 1 |
| Leys, D | 1 |
| Delisse, B | 1 |
| Warot, P | 1 |
| Senard, JM | 1 |
| Rascol, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy[NCT00103597] | Phase 1 | 50 participants | Interventional | 2005-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for domperidone and Hypotension, Orthostatic
| Article | Year |
|---|---|
Fludrocortisone for orthostatic hypotension.
Topics: Bias; Diabetes Mellitus; Domperidone; Dysautonomia, Familial; Fludrocortisone; Humans; Hypotension, | 2021 |
Domperidone for Hypotension in Parkinson's Disease: A Systematic Review.
Topics: Animals; Arrhythmias, Cardiac; Databases, Bibliographic; Death, Sudden, Cardiac; Domperidone; Dopami | 2017 |
Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension.
Topics: Antihypertensive Agents; Antiparkinson Agents; Clonidine; Disease Management; Domperidone; Dopamine | 2017 |
2 trials available for domperidone and Hypotension, Orthostatic
| Article | Year |
|---|---|
Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Blood Pressure; Cross-Over Studies; Domperidone; | 2007 |
Blood pressure effects of apomorphine and domperidone in parkinsonism.
Topics: Adult; Aged; Aged, 80 and over; Apomorphine; Blood Pressure; Clinical Trials as Topic; Domperidone; | 1987 |
9 other studies available for domperidone and Hypotension, Orthostatic
| Article | Year |
|---|---|
Recognition and Management of Orthostatic Hypotension in Primary Care.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Curriculum; Domperidone; Education, Medical, Continu | 2018 |
Acute orthostatic hypotension when starting dopamine agonist therapy in parkinson disease: the role of domperidone therapy.
Topics: Acute Disease; Domperidone; Dopamine Agonists; Dopamine Antagonists; Humans; Hypotension, Orthostati | 2001 |
Hypertension with orthostatic hypotension: interest of verapamil.
Topics: Adult; Aged; Blood Pressure; Domperidone; Female; Follow-Up Studies; Heart Rate; Humans; Hypertensio | 1987 |
[Arterial hypertension with orthostatic hypotension caused by dysregulation of the baroreflex. Correction with domperidone and verapamil].
Topics: Domperidone; Drug Therapy, Combination; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle | 1986 |
Peripheral dopaminergic blockade for the treatment of diabetic orthostatic hypotension.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Diabetic Neuropathies; Diet; Domperidone; Female | 1988 |
[Domperidone and Parkinson disease].
Topics: Domperidone; Female; Humans; Hypotension, Orthostatic; Middle Aged; Parkinson Disease, Secondary | 1988 |
Adrenal catecholamine concentration after domperidone.
Topics: Adrenal Medulla; Animals; Catecholamines; Domperidone; Dose-Response Relationship, Drug; Epinephrine | 1987 |
Orthostatic hypotension due to diabetic autonomic neuropathy? Treatment with domperidone.
Topics: Aged; Diabetic Neuropathies; Domperidone; Female; Humans; Hypotension, Orthostatic; Receptors, Dopam | 1987 |
Domperidone in the management of orthostatic hypotension.
Topics: Domperidone; Humans; Hypotension, Orthostatic | 1985 |