domperidone has been researched along with Hypogalactia in 18 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Hypogalactia: A condition of less than normal MILK secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone was given at a dose of 10 mg thrice daily for 14 days." | 2.90 | Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial. ( Asztalos, EV; Campbell-Yeo, M; daSilva, OP; Ito, S; Kiss, A; Knoppert, D, 2019) |
| "Domperidone is a potent dopamine D2 receptor antagonist which stimulates the release of prolactin." | 2.77 | Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial). ( Asztalos, EV; Campbell-Yeo, M; daSilva, OP; Ito, S; Kiss, A; Knoppert, DC, 2012) |
| "To investigate the possibility of a dose-response relationship for the use of domperidone in treating insufficient milk supply in mothers of preterm infants, and to quantify the exposure of the breastfed infant to domperidone." | 2.73 | Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk. ( Davey, K; Hartmann, PE; Ilett, KF; Page-Sharp, M; Simmer, K; Wan, EW, 2008) |
| "The patient presented with withdrawal symptoms after gradual taper and discontinuation of domperidone." | 1.48 | Case report: domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation. ( Doyle, M; Grossman, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 12 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wada, Y | 1 |
| Suyama, F | 1 |
| Sasaki, A | 1 |
| Saito, J | 1 |
| Shimizu, Y | 1 |
| Amari, S | 1 |
| Ito, Y | 1 |
| Sago, H | 1 |
| Doyle, M | 1 |
| Grossman, M | 1 |
| Asztalos, EV | 2 |
| Kiss, A | 2 |
| daSilva, OP | 2 |
| Campbell-Yeo, M | 2 |
| Ito, S | 3 |
| Knoppert, D | 1 |
| Grzeskowiak, LE | 2 |
| Amir, LH | 2 |
| Axelsson, PB | 1 |
| Bjerrum, F | 1 |
| Løkkegaard, EC | 1 |
| Paul, C | 1 |
| Zénut, M | 1 |
| Dorut, A | 1 |
| Coudoré, MA | 1 |
| Vein, J | 1 |
| Cardot, JM | 1 |
| Balayssac, D | 1 |
| Haase, B | 1 |
| Taylor, SN | 1 |
| Mauldin, J | 1 |
| Johnson, TS | 1 |
| Wagner, CL | 1 |
| Wan, EW | 1 |
| Davey, K | 1 |
| Page-Sharp, M | 1 |
| Hartmann, PE | 1 |
| Simmer, K | 1 |
| Ilett, KF | 1 |
| Jones, W | 1 |
| Breward, S | 1 |
| Duran, MS | 1 |
| Spatz, DL | 1 |
| Knoppert, DC | 1 |
| Bozzo, P | 1 |
| Koren, G | 1 |
| Cann, PA | 1 |
| Read, NW | 1 |
| Holdsworth, CD | 1 |
| Maddern, GJ | 1 |
| Rolfini, G | 1 |
| De Rosa, D | 1 |
| Lupi, AM | 1 |
| Petrelli, V | 1 |
| Petraglia, F | 1 |
| De Leo, V | 1 |
| Sardelli, S | 1 |
| Pieroni, ML | 1 |
| D'Antona, N | 1 |
| Genazzani, AR | 1 |
| Johnston, DG | 1 |
| Haigh, J | 1 |
| Prescott, RW | 1 |
| Heaton, A | 1 |
| Kendall-Taylor, P | 1 |
| Baylis, P | 1 |
| Alberti, KG | 1 |
| Rowe, R | 1 |
| Friesen, H | 1 |
| Cook, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancing Breast Milk Production With Domperidone in Mothers of Preterm Neonates[NCT01512225] | Phase 2 | 90 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology[NCT03221855] | Early Phase 1 | 30 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome is the difference in the proportion of women having a 50% increase in breast milk volume at the end of 14 days of treatment with domperidone compared to mothers receiving placebo (mean day 14 volume minus mean day 0 volume at entry). (NCT01512225)
Timeframe: Day 0 to day 14
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A: Domperidone | 35 |
| Group B: Placebo + Domperidone | 26 |
Number of mothers who achieved 50% increase in milk volume on day 28 (NCT01512225)
Timeframe: day 0 to day 28
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A: Domperidone | 31 |
| Group B: Placebo + Domperidone | 28 |
Mean milk volumes between the two groups at 14 days of study intervention (NCT01512225)
Timeframe: Day 0 and day 14
| Intervention | millilitres (Mean) |
|---|---|
| Group A: Domperidone | 267 |
| Group B: Placebo + Domperidone | 217 |
Mean milk volumes between the two groups at 28 days of study intervention (NCT01512225)
Timeframe: day 0 and 28
| Intervention | millilitres (Mean) |
|---|---|
| Group A: Domperidone | 290 |
| Group B: Placebo + Domperidone | 302 |
change on the volume of milk from day 0 to day 14 between the two groups (NCT01512225)
Timeframe: days 0 and 14
| Intervention | millilitres (Mean) |
|---|---|
| Group A: Domperidone | 254 |
| Group B: Placebo + Domperidone | 175 |
change on the volume of milk from day 15 to day 28 between the two groups (NCT01512225)
Timeframe: day 15 and day 28
| Intervention | millilitres (Mean) |
|---|---|
| Group A: Domperidone | 22 |
| Group B: Placebo + Domperidone | 49 |
Provision of breast milk at 6 weeks post term gestation as primary source of nutrition (NCT01512225)
Timeframe: 6 weeks post term gestation
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A: Domperidone | 19 |
| Group B: Placebo + Domperidone | 20 |
provision of breast milk as the primary source of nutrition (NCT01512225)
Timeframe: term gestation
| Intervention | Participants (Count of Participants) |
|---|---|
| Group A: Domperidone | 26 |
| Group B: Placebo + Domperidone | 27 |
1 review available for domperidone and Hypogalactia
| Article | Year |
|---|---|
[Pharmaceutical treatment of lactation deficiency lacks evidence].
Topics: Breast Feeding; Domperidone; Dopamine Antagonists; Evidence-Based Medicine; Female; Humans; Lactatio | 2014 |
5 trials available for domperidone and Hypogalactia
| Article | Year |
|---|---|
Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial.
Topics: Adult; Canada; Domperidone; Dopamine Antagonists; Female; Galactogogues; Gestational Age; Humans; In | 2019 |
Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk.
Topics: Breast Feeding; Clinical Protocols; Domperidone; Dopamine Antagonists; Dose-Response Relationship, D | 2008 |
Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial).
Topics: Domperidone; Dopamine Antagonists; Double-Blind Method; Female; Galactogogues; Humans; Infant, Extre | 2012 |
Galactorrhoea as side effect of domperidone.
Topics: Adult; Domperidone; Female; Galactorrhea; Humans; Lactation Disorders; Middle Aged; Pregnancy; Prola | 1983 |
Domperidone in defective and insufficient lactation.
Topics: Adult; Clinical Trials as Topic; Domperidone; Double-Blind Method; Female; Humans; Lactation Disorde | 1985 |
12 other studies available for domperidone and Hypogalactia
| Article | Year |
|---|---|
Effects of Domperidone in Increasing Milk Production in Mothers with Insufficient Lactation for Infants in the Neonatal Intensive Care Unit.
Topics: Adult; Breast Feeding; Domperidone; Drug Monitoring; Female; Galactogogues; Humans; Infant, Newborn; | 2019 |
Case report: domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation.
Topics: Adult; Breast Feeding; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; | 2018 |
Pharmacological management of low milk supply with domperidone: separating fact from fiction.
Topics: Age Factors; Arrhythmias, Cardiac; Breast Feeding; Death, Sudden, Cardiac; Domperidone; Dopamine Ant | 2014 |
Pharmacological management of low milk supply with domperidone: separating fact from fiction.
Topics: Breast Feeding; Domperidone; Dopamine Antagonists; Female; Humans; Lactation Disorders; Male | 2015 |
Response to "Use of domperidone to increase breast milk supply: further consideration of the benefit-risk ratio is required".
Topics: Breast Feeding; Domperidone; Female; Humans; Lactation Disorders; Milk, Human; Odds Ratio | 2015 |
Domperidone for Treatment of Low Milk Supply in Breast Pump-Dependent Mothers of Hospitalized Premature Infants: A Clinical Protocol.
Topics: Breast Milk Expression; Clinical Protocols; Domperidone; Drug Administration Schedule; Female; Follo | 2016 |
Use of domperidone to enhance lactation: what is the evidence?
Topics: Breast Feeding; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Humans; | 2011 |
A mother with glandular hypoplasia and a late preterm infant.
Topics: Adult; Breast; Breast Feeding; Domperidone; Dopamine Antagonists; Female; Humans; Infant, Newborn; I | 2011 |
Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]?
Topics: Arrhythmias, Cardiac; Canada; Death, Sudden, Cardiac; Domperidone; Female; Galactogogues; Humans; La | 2012 |
Galactorrhoea due to domperidone.
Topics: Adult; Domperidone; Female; Galactorrhea; Gastroesophageal Reflux; Humans; Lactation Disorders; Preg | 1983 |
[Hypogalactia: therapeutic possibilities].
Topics: Administration, Oral; Adult; Domperidone; Female; Humans; Lactation; Lactation Disorders; Metoclopra | 1989 |
Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.
Topics: Adult; Animals; Biological Assay; Domperidone; Female; Galactorrhea; Humans; Insulin; Lactation Diso | 1985 |