domperidone has been researched along with Hypertension in 22 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A central dopaminergic origin has been demonstrated for the bromocriptine-induced tachycardia in conscious, normotensive rats." | 7.71 | Central bromocriptine-induced tachycardia is reversed to bradycardia in conscious, deoxycorticosterone acetate-salt hypertensive rats. ( Lahlou, S, 2001) |
| "The aim of the study was to investigate whether or not the development of hypertension is influenced by chronic treatment with bromocriptine and/or domperidone." | 7.67 | Attenuated development of hypertension by chronic administration of bromocriptine in Doca-salt hypertensive rats. ( Ijichi, H; Kambara, S; Okabayashi, H; Takahashi, H; Yoshimura, M, 1986) |
| "Administration of two dopamine antagonists, domperidone and metoclopramide, gave a marked rise in blood pressure with an increase in plasma catecholamines in two patients with pheochromocytoma." | 7.67 | Increase in blood pressure in pheochromocytoma induced by domperidone and metoclopramide. ( Arai, M; Ichikawa, S; Murata, K; Ono, Z, 1985) |
| "In three patients with orthostatic hypotension successfully treated by the peripheral dopaminergic antagonist domperidone 60 mg/day, the subsequent introduction of verapamil 240 mg/day did not modify the standing-induced decrease in systolic blood pressure: 46." | 5.27 | Hypertension with orthostatic hypotension: interest of verapamil. ( Chamontin, BF; Montastruc, JL; Salvador, MJ, 1987) |
| "Bromocriptine may be useful in the treatment of hypertension in patients with Parkinson's disease." | 5.27 | Parkinson's disease and hypertension: chronic bromocriptine treatment. ( Chamontin, B; Montastruc, JL; Rascol, A, 1985) |
| "The effect of the intravenous administration of dihydroergotoxine (6 micrograms/kg) on arterial blood pressure, heart rate, and plasma concentrations of norepinephrine and 3,4-dihydroxyphenylacetic acid (the deaminated dopamine metabolite) was studied in 20 subjects with essential hypertension (8 men and 12 women aged 32-68 years old, World Health Organization Class I-II)." | 5.06 | Peripheral dopamine receptors in the antihypertensive action of dihydroergotoxine in humans. ( Cherchi, A; Gessa, G; Mercuro, G; Rivano, CA; Rossetti, ZL; Ruscazio, M; Tocco, L, 1987) |
| "A central dopaminergic origin has been demonstrated for the bromocriptine-induced tachycardia in conscious, normotensive rats." | 3.71 | Central bromocriptine-induced tachycardia is reversed to bradycardia in conscious, deoxycorticosterone acetate-salt hypertensive rats. ( Lahlou, S, 2001) |
| "To assess the role of spinal dopamine receptors in mediation of hypotension induced by systemic administration of the dopamine D2 receptor agonist, bromocriptine, conscious deoxycorticosterone acetate (DOCA)-salt hypertensive rats were pretreated with either intravenous (i." | 3.70 | Hypotensive action of bromocriptine in the DOCA-salt hypertensive rat: contribution of spinal dopamine receptors. ( Duarte, GP; Lahlou, S, 1998) |
| " The dopamine D2 receptor antagonist, domperidone, caused hypertension in ropinirole-but not vehicle-treated rats." | 3.69 | Tolerance to peripheral, but not central, effects of ropinirole, a selective dopamine D2-like receptor agonist. ( Eden, RJ; Parker, SG; Raval, P; Yeulet, S, 1994) |
| " To elucidate the role of central and peripheral dopaminergic systems in the pathogenesis of DOCA/NaCl hypertension, we examined the effects of quinpirole on mean arterial pressure, heart rate, plasma norepinephrine, epinephrine, arginine vasopressin and atrial natriuretic peptide (ANP) in conscious 4-week-old DOCA/NaCl hypertensive and normotensive control rats." | 3.67 | Blunted pressor responsiveness to quinpirole, a specific dopamine D2 receptor agonist, in conscious deoxycorticosterone acetate/NaCl hypertensive rats is related to atrial natriuretic peptide release. ( Chen, YF; Jin, HK; Nagahama, S; Paul, R, 1988) |
| "The aim of the study was to investigate whether or not the development of hypertension is influenced by chronic treatment with bromocriptine and/or domperidone." | 3.67 | Attenuated development of hypertension by chronic administration of bromocriptine in Doca-salt hypertensive rats. ( Ijichi, H; Kambara, S; Okabayashi, H; Takahashi, H; Yoshimura, M, 1986) |
| "Administration of two dopamine antagonists, domperidone and metoclopramide, gave a marked rise in blood pressure with an increase in plasma catecholamines in two patients with pheochromocytoma." | 3.67 | Increase in blood pressure in pheochromocytoma induced by domperidone and metoclopramide. ( Arai, M; Ichikawa, S; Murata, K; Ono, Z, 1985) |
| "Domperidone pretreatment prevented the GFR increase induced by nicardipine and increased the noradrenaline response (+107%), but did not change the other actions of nicardipine." | 2.66 | Haemodynamic (systemic and renal) and humoral interactions between nicardipine and domperidone in hypertensives. ( Lucarini, AR; Salvetti, A, 1987) |
| "Both hypertension and orthostatic hypotension (OH) are strongly age-associated and are common management problems in older people." | 2.55 | Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension. ( Anpalahan, M; Chisholm, P, 2017) |
| "Initial use of dopamine agonists in the treatment of hypertension and its possible involvement in the etiology and maintenance of hypertension are discussed." | 2.37 | Dopamine receptors and hypertension. Physiologic and pharmacologic implications. ( Goldberg, LI, 1984) |
| "In 6 hypertensive patients with Parkinson's disease, chronic treatment with bromocriptine (46." | 1.27 | [How do we explain the antihypertensive effect of bromocriptine? Clinical and experimental contribution]. ( Chamontin, B; Montastruc, JL; Rascol, A, 1984) |
| "In three patients with orthostatic hypotension successfully treated by the peripheral dopaminergic antagonist domperidone 60 mg/day, the subsequent introduction of verapamil 240 mg/day did not modify the standing-induced decrease in systolic blood pressure: 46." | 1.27 | Hypertension with orthostatic hypotension: interest of verapamil. ( Chamontin, BF; Montastruc, JL; Salvador, MJ, 1987) |
| "Bromocriptine may be useful in the treatment of hypertension in patients with Parkinson's disease." | 1.27 | Parkinson's disease and hypertension: chronic bromocriptine treatment. ( Chamontin, B; Montastruc, JL; Rascol, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (63.64) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chisholm, P | 1 |
| Anpalahan, M | 1 |
| Toscano, CF | 1 |
| Lahlou, S | 3 |
| Goldberg, LI | 1 |
| Chamontin, B | 3 |
| Montastruc, JL | 4 |
| Rascol, A | 2 |
| Nagahama, S | 2 |
| Chen, YF | 2 |
| Oparil, S | 1 |
| Parker, SG | 1 |
| Raval, P | 1 |
| Yeulet, S | 1 |
| Eden, RJ | 1 |
| Forte, P | 1 |
| Martin, G | 1 |
| Luchsinger, A | 3 |
| Hernandez, O | 1 |
| Romero, E | 1 |
| Velasco, M | 3 |
| Corujo, M | 1 |
| Valery, J | 1 |
| Morales, E | 1 |
| Duarte, GP | 1 |
| Grilli, M | 1 |
| Chamontin, BF | 1 |
| Salvador, MJ | 1 |
| van den Buuse, M | 1 |
| Lambrechts, AC | 1 |
| Bernini, GP | 1 |
| Lucarini, AR | 2 |
| Franchi, F | 1 |
| Salvetti, A | 2 |
| Villeneuve, A | 1 |
| Berlan, M | 1 |
| Salvador, M | 1 |
| Jin, HK | 1 |
| Paul, R | 1 |
| Kambara, S | 1 |
| Yoshimura, M | 1 |
| Okabayashi, H | 1 |
| Takahashi, H | 1 |
| Ijichi, H | 1 |
| Mercuro, G | 2 |
| Rossetti, Z | 1 |
| Rivano, AC | 1 |
| Tocco, L | 2 |
| Ruscazio, M | 2 |
| Stefanini, E | 1 |
| Gessa, GL | 1 |
| Cherchi, A | 2 |
| Rossetti, ZL | 1 |
| Rivano, CA | 1 |
| Gessa, G | 1 |
| Ichikawa, S | 1 |
| Ono, Z | 1 |
| Arai, M | 1 |
| Murata, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Mechanisms of Human Spinal Cord Stimulation for Purpose of Treating Restless Leg Syndrome[NCT03539081] | 15 participants (Actual) | Interventional | 2016-07-05 | Completed | |||
| Randomized, Controlled Pilot Trial of Domperidone in Relapsing-Remitting Multiple Sclerosis[NCT02493049] | Phase 2 | 17 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Response will measured by peroneal nerve microneurography to the lower limb during epidural spinal cord stimulation in patients with chronic back pain.~Percent change MSNA burst frequency from baseline to 60 minutes" (NCT03539081)
Timeframe: Baseline to 60 minutes
| Intervention | Percent change MSNA burst frequency (Mean) |
|---|---|
| Subjects With RLS | -29 |
| Subjects Without RLS | -24 |
The response will be measured by Doppler ultrasound of the femoral artery during epidural spinal cord stimulation in patients with chronic back pain. (NCT03539081)
Timeframe: Baseline and 1.5 Hours
| Intervention | percentage of change (Mean) |
|---|---|
| Subjects With RLS | 24 |
| Subjects Without RLS | 22 |
2 reviews available for domperidone and Hypertension
| Article | Year |
|---|---|
Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension.
Topics: Antihypertensive Agents; Antiparkinson Agents; Clonidine; Disease Management; Domperidone; Dopamine | 2017 |
Dopamine receptors and hypertension. Physiologic and pharmacologic implications.
Topics: Animals; Benzazepines; Blood Pressure; Bromocriptine; Domperidone; Dopamine; Ergolines; Fenoldopam; | 1984 |
5 trials available for domperidone and Hypertension
| Article | Year |
|---|---|
Dopaminergic influence on the cardiovascular response to exercise in normotensive and hypertensive subjects.
Topics: Adult; Blood Pressure; Cross-Over Studies; Domperidone; Dopamine; Dopamine Antagonists; Exercise; Fe | 1995 |
Metoclopramide and domperidone block the antihypertensive effect of bromocriptine in hypertensive patients.
Topics: Adult; Aldosterone; Antihypertensive Agents; Blood Pressure; Bromocriptine; Case-Control Studies; Cr | 1998 |
Humoral effects of metoclopramide and domperidone in normal subjects and in hypertensive patients.
Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Domperidone; Female; Humans; Hydrocortisone; Hypert | 1988 |
Haemodynamic (systemic and renal) and humoral interactions between nicardipine and domperidone in hypertensives.
Topics: Adult; Aldosterone; Domperidone; Drug Interactions; Female; Glomerular Filtration Rate; Heart Rate; | 1987 |
Peripheral dopamine receptors in the antihypertensive action of dihydroergotoxine in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Aged; Blood Pressure; Depression, Chemical; Dihydroergotoxine | 1987 |
15 other studies available for domperidone and Hypertension
| Article | Year |
|---|---|
Blood pressure effects of intravenous apomorphine in conscious deoxycorticosterone-acetate salt-hypertensive rats.
Topics: Animals; Apomorphine; Behavior, Animal; Blood Pressure; Desoxycorticosterone; Domperidone; Dopamine | 2003 |
[How do we explain the antihypertensive effect of bromocriptine? Clinical and experimental contribution].
Topics: Adrenergic alpha-Antagonists; Aged; Animals; Antihypertensive Agents; Bromocriptine; Dogs; Domperido | 1984 |
Mechanism of the depressor effect of bromocriptine in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Bromocriptine; Depression, Chemical; Domperidone; Epin | 1984 |
Tolerance to peripheral, but not central, effects of ropinirole, a selective dopamine D2-like receptor agonist.
Topics: Administration, Oral; Analysis of Variance; Animals; Bethanidine; Blood Pressure; Bromocriptine; Dec | 1994 |
Effects of dopaminergic antagonists on dopamine-induced cardiovascular and insulin secretion actions in hypertensive patients.
Topics: Blood Glucose; Blood Pressure; Domperidone; Dopamine; Dopamine Antagonists; Heart; Heart Rate; Human | 1993 |
Hypotensive action of bromocriptine in the DOCA-salt hypertensive rat: contribution of spinal dopamine receptors.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bromocriptine; Desoxycorticosterone; | 1998 |
Central bromocriptine-induced tachycardia is reversed to bradycardia in conscious, deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Aorta, Abdominal; Blood Pressure; Bradycardia; Bromocriptine; Desoxycorticosterone; Domperi | 2001 |
Hypertension with orthostatic hypotension: interest of verapamil.
Topics: Adult; Aged; Blood Pressure; Domperidone; Female; Follow-Up Studies; Heart Rate; Humans; Hypertensio | 1987 |
Bromocriptine-induced decrease in blood pressure in conscious spontaneously hypertensive rats: evidence for a peripheral site of action.
Topics: Animals; Blood Pressure; Bromocriptine; Domperidone; Hypertension; Injections, Intraperitoneal; Inje | 1989 |
[Arterial hypertension with orthostatic hypotension caused by dysregulation of the baroreflex. Correction with domperidone and verapamil].
Topics: Domperidone; Drug Therapy, Combination; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle | 1986 |
Blunted pressor responsiveness to quinpirole, a specific dopamine D2 receptor agonist, in conscious deoxycorticosterone acetate/NaCl hypertensive rats is related to atrial natriuretic peptide release.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Pressure; Desoxycorticosterone; Domp | 1988 |
Attenuated development of hypertension by chronic administration of bromocriptine in Doca-salt hypertensive rats.
Topics: Animals; Blood Pressure; Bromocriptine; Desoxycorticosterone; Dihydroxyphenylalanine; Domperidone; D | 1986 |
[Peripheral presynaptic dopamine receptors control the release of norepinephrine and arterial pressure in humans].
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Apomorphine; Blood Pressure; Bromocriptine; Dihydroergotoxine | 1987 |
Increase in blood pressure in pheochromocytoma induced by domperidone and metoclopramide.
Topics: Adrenal Gland Neoplasms; Adult; Blood Pressure; Domperidone; Epinephrine; Female; Humans; Hypertensi | 1985 |
Parkinson's disease and hypertension: chronic bromocriptine treatment.
Topics: Aged; Bromocriptine; Domperidone; Female; Humans; Hypertension; Male; Parkinson Disease | 1985 |