domperidone and Gastroesophageal Reflux studies

Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.

Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Research Excerpts

Excerpt	Relevance	Reference
"To study and document the efficacy and tolerability of rabeprazole and domperidone in the treatment of patients suffering from gastro-oesophageal reflux disease (GERD), an open, prospective, non-comparative study was carried out among 50 adult patients of either sex attending gastroenterology OPD of a leading, tertiary-care teaching hospital in Mumbai with the clinical diagnosis of GERD."	9.13	Rabeprazole plus domperidone: the answer for gastro-oesophageal reflux disease. ( Dabholkar, P; Sawant, P; Shahani, S, 2008)
"To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesophageal reflux."	9.12	Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux. ( Bondi, E; Daga, MK; Sachdev, GK; Sharma, B; Sharma, M, 2007)
"This study sought to define the therapeutic efficacy of domperidone in infants and children with gastroesophageal reflux."	9.07	Efficacy of domperidone in infants and children with gastroesophageal reflux. ( Bines, JE; Kleinman, RE; Quinlan, JE; Treves, S; Winter, HS, 1992)
"To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children."	8.82	Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old. ( Baber, N; Pritchard, DS; Stephenson, T, 2005)
"Domperidone has been widely used in children with gastroesophageal reflux disease (GERD)."	7.83	Effects of Domperidone on QT Interval in Children with Gastroesophageal Reflux Disease. ( Buddharaksa, Y; Khositseth, A; Ngoenmak, T; Treepongkaruna, S, 2016)
" Galactorrhea is a well-known side effect of domperidone, and is usually associated with hyperprolactinemia."	7.81	Euprolactinemic galactorrhea secondary to domperidone treatment. ( Berberoglu, M; Demir, AM; Kansu, A; Kuloglu, Z, 2015)
"The possible pathophysiology of the relationship between gastro-esophageal reflux disease and apnea of prematurity has been widely investigated."	7.81	Gaviscon and domperidon responsive apnea episodes associated with gastro-esophageal reflux disease in twins. ( Bilgin, H; Eren, A; Kara, S, 2015)
"To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy."	7.79	Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. ( Chen, Q; Liang, SW; Lv, HJ; Qiu, ZM; Xu, XH; Yang, ZM; Yu, L, 2013)
"Domperidone, a "hidden" neuroleptic, is used for symptomatic treatment of gastroesophageal reflux disease, despite its uncertain efficacy."	7.78	Domperidone: ventricular arrhythmia and sudden death (continued). ( , 2012)
"Twice-daily dosing of proton pump inhibitor (PPI), the standard therapy for gastro-oesophageal reflux disease (GERD), is an effective therapy for GERD in SSc."	6.84	Effectiveness of add-on therapy with domperidone vs alginic acid in proton pump inhibitor partial response gastro-oesophageal reflux disease in systemic sclerosis: randomized placebo-controlled trial. ( Chunlertrith, K; Foocharoen, C; Mahakkanukrauh, A; Mairiang, P; Namvijit, S; Nanagara, R; Suwannaroj, S; Wantha, O, 2017)
"Cisapride was previously used in the same indication."	6.74	Domperidone versus cisapride in the treatment of infant regurgitation and increased acid gastro-oesophageal reflux: a pilot study. ( Advani, N; Alatas, S; Firmansyah, A; Hegar, B; Vandenplas, Y, 2009)
"Neonatal gastroesophageal reflux (GER) is primarily due to a transient motility disorder and characterized by a prevalence of weakly acid refluxes."	6.73	Short-term effect of domperidone on gastroesophageal reflux in newborns assessed by combined intraluminal impedance and pH monitoring. ( Cresi, F; Marinaccio, C; Miniero, R; Russo, MC; Silvestro, L, 2008)
"Cisapride was more effective than domperidone in the REFLUX-Group."	6.68	Study with two prokinetics in functional dyspepsia and GORD: domperidone vs. cisapride. ( Guyot, J; Halter, F; Hammer, B; Miazza, BM; Staub, P, 1997)
"Evidence demonstrates a link between gastroesophageal reflux disease and chronic allograft dysfunction in lung transplant recipients."	5.40	Domperidone for delayed gastric emptying in lung transplant recipients with and without gastroesophageal reflux. ( Clarke, JO; Ensor, CR; Lidor, AO; McDyer, JF; Orens, JB; Sheer, AJ, 2014)
"The purpose is to evaluate the effectiveness of itopride (IP) and domperidone (DP) in the treatment of patients with gastroesophageal reflux disease (GERD), in combination with diabetes mellitus (DM) type 1 and 2."	5.17	[Comparative data of prokinetics in treatment of gastroesophageal reflux disease in patients with diabetes]. ( Fedorchenko, IuL, 2013)
"To study and document the efficacy and tolerability of rabeprazole and domperidone in the treatment of patients suffering from gastro-oesophageal reflux disease (GERD), an open, prospective, non-comparative study was carried out among 50 adult patients of either sex attending gastroenterology OPD of a leading, tertiary-care teaching hospital in Mumbai with the clinical diagnosis of GERD."	5.13	Rabeprazole plus domperidone: the answer for gastro-oesophageal reflux disease. ( Dabholkar, P; Sawant, P; Shahani, S, 2008)
"To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesophageal reflux."	5.12	Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux. ( Bondi, E; Daga, MK; Sachdev, GK; Sharma, B; Sharma, M, 2007)
"This study sought to define the therapeutic efficacy of domperidone in infants and children with gastroesophageal reflux."	5.07	Efficacy of domperidone in infants and children with gastroesophageal reflux. ( Bines, JE; Kleinman, RE; Quinlan, JE; Treves, S; Winter, HS, 1992)
" The systematic review included medical trials written in English which were published between 2000 and 2016 and were retrieved from PubMed and Scopus using the keywords 'PPI-resistant gastro-oesophageal reflux', 'alginate AND gastro-oesophageal reflux', 'hyaluronic acid AND gastro-oesophageal reflux', 'prokinetics AND gastro-oesophageal reflux', 'sucralfate AND gastro-oesophageal reflux' and 'baclofen AND gastro-oesophageal reflux'."	4.98	Treatment of PPI-resistant gastro-oesophageal reflux: A systematic review. ( Gallusi, G; Pontone, S, 2018)
"To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer."	4.91	[Cardiac adverse effects of domperidone in adult patients: a systematic review]. ( Avila, A; Caraballo, L; Marzi, M; Molina, G; Piskulic, L; Weitz, D, 2015)
"To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children."	4.82	Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old. ( Baber, N; Pritchard, DS; Stephenson, T, 2005)
" These pharmacological differences have clinical relevance: metoclopramide and domperidon could not consistently prove efficacy in functional dyspepsia and GORD."	4.79	[Pharmacologic and clinical differentiation of prokinetic drugs]. ( Greving, I; May, B, 1996)
"The author discusses the role of prokinetic agents, such as bethanechol, metoclopramide, domperidone, and cisipride in the management of gastroesophageal reflux disease."	4.78	Gastric emptying in gastroesophageal reflux and the therapeutic role of prokinetic agents. ( McCallum, RW, 1990)
"Systemic sclerosis (SSc) patients often become refractory to proton pump inhibitors (PPI)-a standard treatment for gastroesophageal reflux disease (GERD)-and intolerant to PPI in combination with domperidone."	4.31	Cost-effectiveness of alginic acid in combination with proton pump inhibitor for the treatment of gastroesophageal reflux disease in systemic sclerosis patients. ( Chaiyarit, J; Foocharoen, C; Kingkaew, P; Mahakkanukrauh, A; Manasirisuk, W; Sangchan, A; Suwannaroj, S; Teerawattananon, Y, 2023)
"The possible pathophysiology of the relationship between gastro-esophageal reflux disease and apnea of prematurity has been widely investigated."	3.81	Gaviscon and domperidon responsive apnea episodes associated with gastro-esophageal reflux disease in twins. ( Bilgin, H; Eren, A; Kara, S, 2015)
"Non-acid GERC had the similar cough character, cough symptom score, and capsaicin cough sensitivity to acid GERC."	3.81	Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux. ( Chen, Q; Liang, S; Lü, H; Qiu, Z; Xu, X; Yang, Z; Yu, L, 2015)
"Domperidone and metoclopramide are prokinetics commonly prescribed off-label to infants and younger children in an attempt to treat gastro-oesophageal reflux symptoms."	3.81	Prokinetics prescribing in paediatrics: evidence on cisapride, domperidone, and metoclopramide. ( Ashby, D; Croft, NM; Mt-Isa, S; Sutcliffe, A; Tomlin, S; Underwood, M; Williamson, P, 2015)
" Galactorrhea is a well-known side effect of domperidone, and is usually associated with hyperprolactinemia."	3.81	Euprolactinemic galactorrhea secondary to domperidone treatment. ( Berberoglu, M; Demir, AM; Kansu, A; Kuloglu, Z, 2015)
"To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy."	3.79	Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. ( Chen, Q; Liang, SW; Lv, HJ; Qiu, ZM; Xu, XH; Yang, ZM; Yu, L, 2013)
"Domperidone, a "hidden" neuroleptic, is used for symptomatic treatment of gastroesophageal reflux disease, despite its uncertain efficacy."	3.78	Domperidone: ventricular arrhythmia and sudden death (continued). ( , 2012)
"Domperidone is a dopamine antagonist that has recently been released in Canada."	3.76	Domperidone, a new dopamine antagonist. ( Champion, MC; Hartnett, M; Yen, M, 1986)
"To determine whether oral domperidone is associated with QT interval prolongation and ventricular arrhythmia and to identify factors that can influence these effects."	3.74	Effect of domperidone on QT interval in neonates. ( Djeddi, D; Kongolo, G; Lefaix, C; Léké, A; Mounard, J, 2008)
"The influence of the dopamine receptor blocking agent domperidone on prolactin and TSH secretion was studied in 16 infants, aged 10-360 days, who were treated for gastroesophageal reflux."	3.67	Increased serum prolactin but normal TSH during prolonged domperidone treatment in children. ( Deprettere, AR; Du Caju, MV; Van Acker, KJ, 1987)
"Twice-daily dosing of proton pump inhibitor (PPI), the standard therapy for gastro-oesophageal reflux disease (GERD), is an effective therapy for GERD in SSc."	2.84	Effectiveness of add-on therapy with domperidone vs alginic acid in proton pump inhibitor partial response gastro-oesophageal reflux disease in systemic sclerosis: randomized placebo-controlled trial. ( Chunlertrith, K; Foocharoen, C; Mahakkanukrauh, A; Mairiang, P; Namvijit, S; Nanagara, R; Suwannaroj, S; Wantha, O, 2017)
"Sixty patients with GERD were divided into equal groups according to performed therapy: standard drug treatment or its combination with psychotherapeutic methods."	2.79	[Role of psychological correction in the combination treatment of patients with gastroesophageal reflux disease]. ( Bitkova, EN; Dicheva, DT; Iurenev, GL; Maev, IV; Sirota, NA, 2014)
"Cisapride was previously used in the same indication."	2.74	Domperidone versus cisapride in the treatment of infant regurgitation and increased acid gastro-oesophageal reflux: a pilot study. ( Advani, N; Alatas, S; Firmansyah, A; Hegar, B; Vandenplas, Y, 2009)
"Thirty asthmatic patients with GERD were randomly divided into two groups (group A and group B)."	2.71	Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease. ( Jiang, SP; Li, JG; Liang, RY; Liang, YK; Liu, QL; Zeng, ZY, 2003)
"Cisapride was more effective than domperidone in the REFLUX-Group."	2.68	Study with two prokinetics in functional dyspepsia and GORD: domperidone vs. cisapride. ( Guyot, J; Halter, F; Hammer, B; Miazza, BM; Staub, P, 1997)
"For diagnosis of gastroesophageal reflux, amongst other investigations, esophageal gammagraphy of swallowing, that detects alterations in the mobility of the oesophagus, secondary to a possible oesophagitis."	2.67	[Nocturnal spasmodic cough in the infant. Evolution after antireflux treatment]. ( Baltazar, MA; Botoy, J; Dordal, MT; Marques, L; Roca, I; Server, MT, 1994)
"Gastro-oesophageal reflux (GOR) is a common disorder, characterised by regurgitation of gastric contents into the oesophagus."	2.50	Pharmacological treatment of children with gastro-oesophageal reflux. ( Afzal, NA; Beattie, RM; Bevan, A; Hayen, A; Munro, A; Tighe, M, 2014)
"Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life."	2.43	The diagnosis and management of gastro-oesophageal reflux in infants. ( Hauser, B; Salvatore, S; Vandenplas, Y, 2005)
"The choice of a medical therapy to treat gastroesophageal reflux disease (GERD) centers around several factors, including the efficacy and safety of the agent and the severity of the patient's symptoms and complications."	2.42	Profile and assessment of GERD pharmacotherapy. ( Maton, PN, 2003)
"The key factor in the pathogenesis of GERD is disordered function of the lower esophageal sphincter."	2.40	Prokinetic therapy in gastroesophageal reflux disease. ( Champion, MC, 1997)
" The ideal therapy for GORD will have linear pharmacokinetics, a relatively long plasma half-life (t1/2), a duration of action allowing once daily administration, and a stable effect independent of interactions with food, antacids and other drugs."	2.39	Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease. ( Berstad, A; Hatlebakk, JG, 1996)
"Dyspepsia affects one in four Australians; of those who present in general practice, the majority will have functional or non-ulcer dyspepsia, with no structural explanation for their symptoms."	2.39	Modern management of dyspepsia. ( Talley, NJ, 1996)
" There was no relation between domperidone dosage and QTc change."	1.38	Effects of domperidone on QTc interval in infants. ( Miyague, NI; Salvatore, S; Van Steen, K; Vandenplas, Y; Vieira, MC, 2012)
"Radical treatment of GERD allows the pulmonologist to perform correct respiratory treatment and to prevent the development chronic and life-threatening complications."	1.32	Outcome of laparoscopic Nissen-Rossetti fundoplication in children with gastroesophageal reflux disease and supraesophageal symptoms. ( Castagnetti, M; Gentilino, V; Jasonni, V; Martino, F; Mattioli, G; Montobbio, G; Pini Prato, A; Sacco, O, 2004)
"The gastroesophageal reflux disease was an important cause of the reflux laryngitis which symptoms and signs can be healed by antacids and motile medications."	1.31	[Study on relationship between the reflux laryngitis and gastroesophageal reflux disease]. ( Gong, Q; Zhou, K, 2001)
"Those ascribed to gastroesophageal reflux and vocal abuse have a high resolution rate, although some cases need rescue procedures."	1.30	Clinical evolution of laryngeal granulomas: treatment and prognosis. ( De Biase, NG; de Lima Pontes, PA; Gadelha, EC, 1999)
"The association between GERD and these supraesophageal symptoms may be elusive."	1.30	Supraesophageal manifestations of gastroesophageal reflux disease. ( Al-Sabbagh, G; Wo, JM, 1999)

Research

Studies (89)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Changing of Frequency of Symptoms in SSc Related Omeprazole Resistant GERD Evaluated by Frequency Scale for the Symptoms of GERD (FSSG)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (30.34)	18.7374
1990's	19 (21.35)	18.2507
2000's	17 (19.10)	29.6817
2010's	24 (26.97)	24.3611
2020's	2 (2.25)	2.80

Authors	Studies
Foocharoen, C	2
Kingkaew, P	1
Teerawattananon, Y	1
Mahakkanukrauh, A	2
Suwannaroj, S	2
Manasirisuk, W	1
Chaiyarit, J	1
Sangchan, A	1
Heidinger, M	1
Gorkiewicz, G	1
Freisinger, O	1
Brcic, I	1
Gallusi, G	1
Pontone, S	1
Xu, XH	1
Yang, ZM	1
Chen, Q	2
Yu, L	2
Liang, SW	1
Lv, HJ	1
Qiu, ZM	1
Uña, E	1
Alonso, P	1
Fedorchenko, IuL	1
Lidor, AO	1
Ensor, CR	1
Sheer, AJ	1
Orens, JB	1
Clarke, JO	1
McDyer, JF	1
Xu, X	1
Yang, Z	1
Liang, S	1
Lü, H	1
Qiu, Z	1
Iurenev, GL	1
Sirota, NA	1
Dicheva, DT	1
Bitkova, EN	1
Maev, IV	1
Caraballo, L	2
Molina, G	2
Weitz, D	2
Piskulic, L	2
Avila, A	2
Marzi, M	2
Tighe, M	1
Afzal, NA	1
Bevan, A	1
Hayen, A	1
Munro, A	1
Beattie, RM	1
Demir, AM	1
Kuloglu, Z	1
Berberoglu, M	1
Kansu, A	1
Mt-Isa, S	1
Tomlin, S	1
Sutcliffe, A	1
Underwood, M	1
Williamson, P	1
Croft, NM	1
Ashby, D	1
Ngoenmak, T	1
Treepongkaruna, S	1
Buddharaksa, Y	1
Khositseth, A	1
Bilgin, H	1
Eren, A	1
Kara, S	1
Chunlertrith, K	1
Mairiang, P	1
Namvijit, S	1
Wantha, O	1
Nanagara, R	1
Cresi, F	1
Marinaccio, C	1
Russo, MC	1
Miniero, R	1
Silvestro, L	1
Djeddi, D	1
Kongolo, G	1
Lefaix, C	1
Mounard, J	1
Léké, A	1
Shahani, S	1
Sawant, P	1
Dabholkar, P	1
Collins, KK	1
Sondheimer, JM	1
Hegar, B	1
Alatas, S	1
Advani, N	1
Firmansyah, A	1
Vandenplas, Y	4
Vakhrushev, IaM	1
Potapova, LO	1
Muravtseva, OV	1
Kumar, Y	1
Sarvananthan, R	1
Günlemez, A	1
Babaoğlu, A	1
Arisoy, AE	1
Türker, G	1
Gökalp, AS	1
González Gutiérrez, ML	1
Rubio Pérez, M	1
Vázquez Cortés, S	1
Martínez González de Lema, B	1
Gottrand, F	1
Ndraha, S	1
Vieira, MC	1
Miyague, NI	1
Van Steen, K	1
Salvatore, S	2
Scott, B	1
Hondeghem, LM	1
Gong, Q	1
Zhou, K	1
Jiang, SP	1
Liang, RY	1
Zeng, ZY	1
Liu, QL	1
Liang, YK	1
Li, JG	1
Maton, PN	1
Mattioli, G	1
Sacco, O	1
Gentilino, V	1
Martino, F	1
Pini Prato, A	1
Castagnetti, M	1
Montobbio, G	1
Jasonni, V	1
Pritchard, DS	1
Baber, N	1
Stephenson, T	1
Hauser, B	1
Sharma, B	1
Sharma, M	1
Daga, MK	1
Sachdev, GK	1
Bondi, E	1
Keady, S	1
Young, P	1
Finn, BC	1
Bruetman, JE	1
Trimarchi, H	1
Siupsinskiene, N	1
Uloza, V	1
Pribuisiene, R	1
Butkus, E	1
Kupcinskas, L	1
Levin, G	1
Fisher, RS	1
Maddern, GJ	2
Grill, BB	2
Heinkelein, J	1
Brock-Utne, JG	2
Bron, B	1
Downing, JW	1
Dimopoulos, GE	1
Rubin, J	1
Moshal, MG	1
Lux, G	1
Engel, H	1
Rösch, W	1
Jia, B	1
Robinson, M	1
Carroccio, A	1
Iacono, G	1
Montalto, G	1
Cavataio, F	1
Soresi, M	1
Notarbartolo, A	1
Dordal, MT	1
Baltazar, MA	1
Roca, I	1
Marques, L	1
Server, MT	1
Botoy, J	1
Carella, G	1
Marra, L	1
Talley, NJ	1
May, B	1
Greving, I	1
Hatlebakk, JG	1
Berstad, A	1
Halter, F	1
Staub, P	1
Hammer, B	1
Guyot, J	1
Miazza, BM	1
Champion, MC	2
Wittmann, T	1
Rosztóczy, A	1
Fehér, A	1
Jármay, K	1
Oláh, T	1
Szendrényi, V	1
Kiss, I	1
Al-Sabbagh, G	1
Wo, JM	1
de Lima Pontes, PA	1
De Biase, NG	1
Gadelha, EC	1
Jian, R	1
Taurand, P	1
Bines, JE	1
Quinlan, JE	1
Treves, S	1
Kleinman, RE	1
Winter, HS	1
Pace, F	1
Santalucia, F	1
Bianchi Porro, G	1
McCallum, RW	4
Russell, JE	1
Gedye, A	1
Mandel, H	1
Tirosh, E	1
Berant, M	1
Reynolds, JC	1
Stern, WR	1
Pelemans, W	1
Vantrappen, G	1
Tytgat, GN	3
Nio, CY	1
Dupont, C	1
Molkhou, P	1
Petrovic, N	1
Fraitag, B	1
Depla, AC	1
Bartelsman, JF	1
Roos, CM	1
Jansen, HM	1
Ricci, DA	1
Hartnett, M	1
Yen, M	1
Deprettere, AR	1
Van Acker, KJ	1
Du Caju, MV	1
Sacré-Smits, L	1
Ishikawa, A	1
Sageshima, S	1
Kakuya, K	1
Kohsaka, S	1
Kajii, N	1
Nagashima, T	1
Sakuma, N	1
Kiroff, GK	1
Leppard, PI	1
Jamieson, GG	1
Di Gesù, G	1
Di Vita, G	1
Feo, M	1
Fiasconaro, G	1
Vetri, G	1
Picone, A	1
Friedman, G	1
Hillemeier, AC	1
Semeraro, LA	1
Gryboski, JD	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Effectiveness of Domperidone Versus Alginic Acid Add on Omeprazole Therapy in Omeprazole Resistance Gastroesophageal Reflux in Systemic Sclerosis[NCT01878526]	Phase 3	80 participants (Actual)	Interventional	2013-06-30	Completed
Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology[NCT03221855]	Early Phase 1	30 participants (Actual)	Interventional	2013-03-31	Completed
A Randomized Controlled Trial Comparing Proton Pump Inhibitor Therapy With and Without Interarytenoid Botulinum Toxin Injection for Vocal Fold Granuloma[NCT01678053]	Phase 2	0 participants (Actual)	Interventional	2012-09-30	Withdrawn (stopped due to Was not able to recruit patients for randomization.)
Oral Domperidone for Relief of Gastrointestinal Disorders in Patients Who Failed Standard Therapy[NCT00761254]		42 participants (Actual)	Interventional	2008-08-31	Terminated (stopped due to PI withdrew due to increased responsibilities in clinical department.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Unit scale 0-48 was applied for an outcome measurement of the frequency of symptoms. The unit scale 0 was no symptom and scale 48 was usual symptom of GERD. The changing of the frequency of symptoms was the changing of the unit scale before and after treatment. (NCT01878526)
Timeframe: 8 weeks

Changing of the Quality of Life Which is Evaluated by EQ-5DTM

Intervention	units on a scale (Mean)
Omeprazole Plus Alginic Acid and Placebo of Domperidone	4.6
Omeprazole Plus Domperidone and Placebo of Alginic Acid	4.7

VAS scale 0-100 was applied for an outcome measurement of the quality of life. The VAS scale 0 was the worst quality of life and scale 100 was the best quality of life. The changing of the quality of life was the changing of VAS of quality of life before and after treatment. (NCT01878526)
Timeframe: 8 weeks

Changing of the Severity of Regurgitation

Intervention	VAS (100) (Mean)
Omeprazole Plus Alginic Acid and Placebo of Domperidone	75.7
Omeprazole Plus Domperidone and Placebo of Alginic Acid	76.1

VAS scale 0-100 was applied for an outcome measurement of the severity of regurgitation. The VAS scale 0 was no symptoms of regurgitation and scale 100 was a maximum symptom of regurgitation. The changing of the severity of regurgitation was the changing of VAS before and after treatment. (NCT01878526)
Timeframe: 8 weeks

Changing Severity of Heart Burn of SSc Related Omeprazole Resistant GERD Evaluated by Visual Analogue Score (VAS)

Intervention	VAS (100) (Mean)
Omeprazole Plus Alginic Acid and Placebo of Domperidone	24.9
Omeprazole Plus Domperidone and Placebo of Alginic Acid	23.1

VAS scale 0-100 was applied for an outcome measurement of the severity of heart burn. The VAS scale 0 was no symptoms of heart burn and scale 100 was a maximum symptom of heart burn. The changing of the severity of heart burn was the changing of VAS before and after treatment. (NCT01878526)
Timeframe: 8 weeks

Article	Year
Treatment of PPI-resistant gastro-oesophageal reflux: A systematic review. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2018, Volume: 19, Issue:2 Topics: Baclofen; Benzamides; Chondroitin Sulfates; Domperidone; Drug Combinations; Drug Therapy, Combinatio	2018
High dose of prokinetics for refractory hiccups after chemotherapy or the return to a simple drug. BMJ case reports, 2013, Oct-29, Volume: 2013 Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Domperidone; Dopamine Antagonists	2013
[Proarrhythmic effects of domperidone in infants: a systematic review]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2014, Sep-16, Volume: 38, Issue:5 Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Cisapride; Contraindications; Cytochrome P-450 CYP3A; Dom	2014
Pharmacological treatment of children with gastro-oesophageal reflux. The Cochrane database of systematic reviews, 2014, Nov-24, Issue:11 Topics: Alginates; Aluminum Hydroxide; Child; Child, Preschool; Domperidone; Drug Combinations; Gastroesopha	2014
[Cardiac adverse effects of domperidone in adult patients: a systematic review]. Revista medica de Chile, 2015, Volume: 143, Issue:1 Topics: Adult; Antiemetics; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Female; Gastroesophag	2015
GORD in children. BMJ clinical evidence, 2008, Oct-01, Volume: 2008 Topics: Acute Disease; Administration, Oral; Child; Cross-Sectional Studies; Domperidone; Gastroesophageal R	2008
[Prokinetics in childhood]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:6 Topics: Adolescent; Anti-Ulcer Agents; Antiemetics; Bethanechol; Child; Child, Preschool; Cisapride; Cross-S	2010
Question 2. How effective is domperidone at reducing symptoms of gastro-oesophageal reflux in infants? Archives of disease in childhood, 2012, Volume: 97, Issue:8 Topics: Antiemetics; Domperidone; Evidence-Based Medicine; Gastroesophageal Reflux; Humans; Infant; Male; Pa	2012
Domperidone: limited benefits with significant risk for sudden cardiac death. Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:3 Topics: Action Potentials; Animals; Antiemetics; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists;	2013
Profile and assessment of GERD pharmacotherapy. Cleveland Clinic journal of medicine, 2003, Volume: 70 Suppl 5 Topics: Adult; Aged; Anti-Ulcer Agents; Cisapride; Controlled Clinical Trials as Topic; Domperidone; Esophag	2003
Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old. British journal of clinical pharmacology, 2005, Volume: 59, Issue:6 Topics: Antiemetics; Child; Child, Preschool; Domperidone; Dopamine Antagonists; Evidence-Based Medicine; Ga	2005
The diagnosis and management of gastro-oesophageal reflux in infants. Early human development, 2005, Volume: 81, Issue:12 Topics: Antacids; Cisapride; Domperidone; Erythromycin; Gastric Mucosa; Gastroesophageal Reflux; Histamine H	2005
Update on drugs for gastro-oesophageal reflux disease. Archives of disease in childhood. Education and practice edition, 2007, Volume: 92, Issue:4 Topics: Adolescent; Antacids; Child; Child, Preschool; Cisapride; Contraindications; Domperidone; Erythromyc	2007
[Gastroesophageal reflux as a cause of night sweating]. Anales de medicina interna (Madrid, Spain : 1984), 2007, Volume: 24, Issue:6 Topics: Adult; Aged; Anti-Ulcer Agents; Cholestyramine Resin; Diagnosis, Differential; Domperidone; Female;	2007
[Modern attitude towards management of laryngopharyngeal form of gastroesophageal reflux disease. Lithuanian clinical practice guidelines for adults]. Medicina (Kaunas, Lithuania), 2007, Volume: 43, Issue:10 Topics: Adult; Algorithms; Antacids; Anti-Ulcer Agents; Domperidone; Dopamine Antagonists; Gastroesophageal	2007
Gastroesophageal reflux disease: an update. Clinical therapeutics, 1983, Volume: 6, Issue:1 Topics: Antacids; Anti-Ulcer Agents; Bethanechol Compounds; Domperidone; Female; Gastroesophageal Reflux; Hu	1983
Prokinetic therapy for gastroesophageal reflux disease. American family physician, 1995, Sep-01, Volume: 52, Issue:3 Topics: Bethanechol; Cisapride; Domperidone; Erythromycin; Gastroesophageal Reflux; Humans; Metoclopramide;	1995
Modern management of dyspepsia. Australian family physician, 1996, Volume: 25, Issue:1 Topics: Adult; Aged; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bismuth; Child; C	1996
[Pharmacologic and clinical differentiation of prokinetic drugs]. Leber, Magen, Darm, 1996, Volume: 26, Issue:4 Topics: Adult; Antiemetics; Child; Cisapride; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; D	1996
Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease. Clinical pharmacokinetics, 1996, Volume: 31, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antacids; Benzimidazoles; Cimetidine; Cisapride; Domperidon	1996
Prokinetic therapy in gastroesophageal reflux disease. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 1997, Volume: 11 Suppl B Topics: Cisapride; Domperidone; Esophagus; Gastroesophageal Reflux; Gastrointestinal Agents; Histamine H2 An	1997
[Drug therapy of gastroesophageal reflux (a prospective controlled clinical trial)]. Orvosi hetilap, 1998, May-03, Volume: 139, Issue:18 Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Domperidone; Dose-Response Relationship, Drug; Fe	1998
[Gastroesophageal reflux in adults: diagnosis and treatment. Conclusions of Consensus Conference: long text. Organized by the French National Society of Gastroenterology and Belgian Royal Society of Gastroenterology/Flemish Society of Gastroenterology. Fr Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:1 Topics: Adult; Age Factors; Antacids; Anti-Ulcer Agents; Cisapride; Clinical Trials as Topic; Diagnosis, Dif	1999
[Disorders of gastric emptying]. Presse medicale (Paris, France : 1983), 1992, Jun-20, Volume: 21, Issue:23 Topics: Cisapride; Diabetes Complications; Domperidone; Dyspepsia; Gastric Emptying; Gastroesophageal Reflux	1992
Gastric emptying in gastroesophageal reflux and the therapeutic role of prokinetic agents. Gastroenterology clinics of North America, 1990, Volume: 19, Issue:3 Topics: Bethanechol; Bethanechol Compounds; Cisapride; Domperidone; Esophagogastric Junction; Gastric Emptyi	1990
Prokinetic agents: a key in the future of gastroenterology. Gastroenterology clinics of North America, 1989, Volume: 18, Issue:2 Topics: Biomechanical Phenomena; Cisapride; Domperidone; Forecasting; Gastroenterology; Gastroesophageal Ref	1989
Oesophageal disease in the elderly. Clinics in gastroenterology, 1985, Volume: 14, Issue:4 Topics: Age Factors; Aged; Alginates; Aluminum Hydroxide; Bethanechol Compounds; Bicarbonates; Deglutition D	1985
The medical therapy of reflux oesophagitis. Bailliere's clinical gastroenterology, 1987, Volume: 1, Issue:4 Topics: Antacids; Bethanechol; Bethanechol Compounds; Cimetidine; Cisapride; Domperidone; Esophagitis, Pepti	1987
Diagnosis and treatment of delayed gastric emptying. Advances in internal medicine, 1988, Volume: 33 Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications;	1988
Domperidone, a new dopamine antagonist. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1986, Sep-01, Volume: 135, Issue:5 Topics: Administration, Oral; Adult; Child; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Dys	1986

Article	Year
[Comparative data of prokinetics in treatment of gastroesophageal reflux disease in patients with diabetes]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2013, Issue:5 Topics: Adult; Benzamides; Benzyl Compounds; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetes Mel	2013
[Role of psychological correction in the combination treatment of patients with gastroesophageal reflux disease]. Terapevticheskii arkhiv, 2014, Volume: 86, Issue:8 Topics: Adult; Aged; Antacids; Combined Modality Therapy; Domperidone; Drug Therapy, Combination; Endoscopy,	2014
Effectiveness of add-on therapy with domperidone vs alginic acid in proton pump inhibitor partial response gastro-oesophageal reflux disease in systemic sclerosis: randomized placebo-controlled trial. Rheumatology (Oxford, England), 2017, Volume: 56, Issue:2 Topics: Adult; Aged; Alginates; Antiemetics; Domperidone; Drug Therapy, Combination; Female; Gastroesophagea	2017
Short-term effect of domperidone on gastroesophageal reflux in newborns assessed by combined intraluminal impedance and pH monitoring. Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:11 Topics: Antiemetics; Domperidone; Dopamine Antagonists; Electric Impedance; Esophageal pH Monitoring; Gastro	2008
Rabeprazole plus domperidone: the answer for gastro-oesophageal reflux disease. Journal of the Indian Medical Association, 2008, Volume: 106, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Domperidone; Dopamine Antagonists	2008
Domperidone versus cisapride in the treatment of infant regurgitation and increased acid gastro-oesophageal reflux: a pilot study. Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:4 Topics: Antiemetics; Cardiovascular System; Cisapride; Domperidone; Electrocardiography; Esophageal pH Monit	2009
[How to raise efficacy of gastroesophageal reflux disease treatment]. Terapevticheskii arkhiv, 2009, Volume: 81, Issue:2 Topics: Adolescent; Adult; Aged; Domperidone; Drug Therapy, Combination; Esophageal pH Monitoring; Female; G	2009
Combination of PPI with a prokinetic drug in gastroesophageal reflux disease. Acta medica Indonesiana, 2011, Volume: 43, Issue:4 Topics: Administration, Oral; Adult; Antiemetics; Domperidone; Double-Blind Method; Drug Synergism; Drug The	2011
Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease. World journal of gastroenterology, 2003, Volume: 9, Issue:5 Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Domperidone; Female; Gastric Emptying; Gastroesophag	2003
Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux. World journal of gastroenterology, 2007, Mar-21, Volume: 13, Issue:11 Topics: Adult; Anti-Asthmatic Agents; Asthma; Domperidone; Dose-Response Relationship, Drug; Double-Blind Me	2007
Domperidone antagonizes the relaxant effect atropine on the lower esophageal sphincter. Anesthesia and analgesia, 1980, Volume: 59, Issue:12 Topics: Adult; Antiemetics; Atropine; Benzimidazoles; Domperidone; Esophagogastric Junction; Gastroesophagea	1980
[Stimulation of esophageal motility with bromoprid, domperidon and metoclopramide. Therapy of esophageal reflux disease]. Fortschritte der Medizin, 1980, May-15, Volume: 98, Issue:18 Topics: Adult; Benzimidazoles; Domperidone; Esophagogastric Junction; Female; Gastroesophageal Reflux; Human	1980
Domperidone plus magnesium hydroxide and aluminum hydroxide: a valid therapy in children with gastroesophageal reflux. A double-blind randomized study versus placebo. Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:4 Topics: Aluminum Hydroxide; Domperidone; Double-Blind Method; Drug Therapy, Combination; Esophagus; Female;	1994
[Nocturnal spasmodic cough in the infant. Evolution after antireflux treatment]. Allergie et immunologie, 1994, Volume: 26, Issue:2 Topics: Adolescent; Child; Child, Preschool; Cisapride; Cough; Domperidone; Female; Gastroesophageal Reflux;	1994
Study with two prokinetics in functional dyspepsia and GORD: domperidone vs. cisapride. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1997, Volume: 48, Issue:2 Topics: Adult; Anti-Ulcer Agents; Cisapride; Domperidone; Double-Blind Method; Dyspepsia; Female; Follow-Up	1997
[Drug therapy of gastroesophageal reflux (a prospective controlled clinical trial)]. Orvosi hetilap, 1998, May-03, Volume: 139, Issue:18 Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Domperidone; Dose-Response Relationship, Drug; Fe	1998
Efficacy of domperidone in infants and children with gastroesophageal reflux. Journal of pediatric gastroenterology and nutrition, 1992, Volume: 14, Issue:4 Topics: Child; Child, Preschool; Diarrhea; Domperidone; Double-Blind Method; Female; Gastric Emptying; Gastr	1992
Domperidone, a new dopamine antagonist. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1986, Sep-01, Volume: 135, Issue:5 Topics: Administration, Oral; Adult; Child; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Dys	1986
Domperidone, metoclopramide, and placebo. All give symptomatic improvement in gastroesophageal reflux. Journal of clinical gastroenterology, 1986, Volume: 8, Issue:2 Topics: Adult; Aged; Domperidone; Double-Blind Method; Female; Gastric Emptying; Gastroesophageal Reflux; Hu	1986

Article	Year
Cost-effectiveness of alginic acid in combination with proton pump inhibitor for the treatment of gastroesophageal reflux disease in systemic sclerosis patients. International journal of rheumatic diseases, 2023, Volume: 26, Issue:10 Topics: Alginic Acid; Cost-Benefit Analysis; Domperidone; Gastroesophageal Reflux; Humans; Infant, Newborn;	2023
Ulcerative reflux esophagitis associated with Clostridium ventriculi following hiatoplasty - is antibiotic treatment necessary? A case report. Zeitschrift fur Gastroenterologie, 2020, Volume: 58, Issue:5 Topics: Aged; Anti-Bacterial Agents; Antiemetics; Clostridium; Clostridium Infections; Domperidone; Esophagi	2020
Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. World journal of gastroenterology, 2013, Jul-21, Volume: 19, Issue:27 Topics: Adult; Baclofen; Capsaicin; Cohort Studies; Cough; Domperidone; Esophageal pH Monitoring; Female; Ga	2013
Domperidone for delayed gastric emptying in lung transplant recipients with and without gastroesophageal reflux. Progress in transplantation (Aliso Viejo, Calif.), 2014, Volume: 24, Issue:1 Topics: Domperidone; Dopamine Antagonists; Female; Gastric Emptying; Gastroesophageal Reflux; Humans; Lung T	2014
Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux. The clinical respiratory journal, 2015, Volume: 9, Issue:2 Topics: Adult; Anti-Ulcer Agents; Baclofen; Capsaicin; Chronic Disease; Cough; Domperidone; Esophageal pH Mo	2015
Euprolactinemic galactorrhea secondary to domperidone treatment. Journal of pediatric endocrinology & metabolism : JPEM, 2015, Volume: 28, Issue:7-8 Topics: Adolescent; Antiemetics; Domperidone; Female; Galactorrhea; Gastroesophageal Reflux; Humans; Hyperpr	2015
Prokinetics prescribing in paediatrics: evidence on cisapride, domperidone, and metoclopramide. Journal of pediatric gastroenterology and nutrition, 2015, Volume: 60, Issue:4 Topics: Adolescent; Antiemetics; Child; Child, Preschool; Cisapride; Domperidone; Drug Prescriptions; Gastro	2015
Effects of Domperidone on QT Interval in Children with Gastroesophageal Reflux Disease. Pediatrics and neonatology, 2016, Volume: 57, Issue:1 Topics: Domperidone; Electrocardiography; Female; Gastroesophageal Reflux; Humans; Infant; Male	2016
Gaviscon and domperidon responsive apnea episodes associated with gastro-esophageal reflux disease in twins. Asia Pacific journal of clinical nutrition, 2015, Volume: 24, Issue:4 Topics: Alginates; Aluminum Hydroxide; Antacids; Antiemetics; Apnea; Diseases in Twins; Domperidone; Drug Co	2015
Effect of domperidone on QT interval in neonates. The Journal of pediatrics, 2008, Volume: 153, Issue:5 Topics: Administration, Oral; Arrhythmias, Cardiac; Domperidone; Dopamine Antagonists; Drug-Related Side Eff	2008
Domperidone-induced QT prolongation: add another drug to the list. The Journal of pediatrics, 2008, Volume: 153, Issue:5 Topics: Animals; Cisapride; Domperidone; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactio	2008
Effect of domperidone on the QTc interval in premature infants. Journal of perinatology : official journal of the California Perinatal Association, 2010, Volume: 30, Issue:1 Topics: Domperidone; Dopamine Antagonists; Electrocardiography; Female; Gastroesophageal Reflux; Humans; Inf	2010
Cinitapride-induced exanthema. Journal of investigational allergology & clinical immunology, 2010, Volume: 20, Issue:2 Topics: Administration, Oral; Aged; Benzamides; Domperidone; Dopamine; Dopamine Antagonists; Drug Therapy, C	2010
Domperidone: QT prolongation in infants. Prescrire international, 2011, Volume: 20, Issue:112 Topics: Antiemetics; Domperidone; Dopamine Antagonists; France; Gastroesophageal Reflux; Humans; Infant; Inf	2011
Effects of domperidone on QTc interval in infants. Acta paediatrica (Oslo, Norway : 1992), 2012, Volume: 101, Issue:5 Topics: Antiemetics; Domperidone; Electrocardiography; Female; Gastroesophageal Reflux; Humans; Infant; Infa	2012
Domperidone: ventricular arrhythmia and sudden death (continued). Prescrire international, 2012, Volume: 21, Issue:129 Topics: Aged; Antipsychotic Agents; Arrhythmias, Cardiac; Death, Sudden; Domperidone; Female; Gastroesophage	2012
[Study on relationship between the reflux laryngitis and gastroesophageal reflux disease]. Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 2001, Volume: 15, Issue:12 Topics: Adult; Antacids; Domperidone; Drugs, Chinese Herbal; Female; Gastroesophageal Reflux; Humans; Laryng	2001
Outcome of laparoscopic Nissen-Rossetti fundoplication in children with gastroesophageal reflux disease and supraesophageal symptoms. Surgical endoscopy, 2004, Volume: 18, Issue:3 Topics: Adolescent; Anti-Ulcer Agents; Asthma; Child; Child, Preschool; Combined Modality Therapy; Domperido	2004
Galactorrhoea due to domperidone. The Medical journal of Australia, 1983, Nov-26, Volume: 2, Issue:11 Topics: Adult; Domperidone; Female; Galactorrhea; Gastroesophageal Reflux; Humans; Lactation Disorders; Preg	1983
Treatment of gastroesophageal reflux. The Western journal of medicine, 1984, Volume: 140, Issue:6 Topics: Bethanechol Compounds; Cimetidine; Domperidone; Gastroesophageal Reflux; Humans; Infant; Infant, New	1984
[Gastritis, stomach ulcer, reflux diseases. Motility effective therapy with Motilium]. ZFA. Zeitschrift fur Allgemeinmedizin, 1982, Jun-30, Volume: 58, Issue:18 Topics: Adult; Domperidone; Duodenal Ulcer; Esophagitis, Peptic; Female; Gastritis; Gastroesophageal Reflux;	1982
[Physiopathology, diagnosis and treatment of esophageal reflux]. Schweizerische medizinische Wochenschrift, 1981, Feb-21, Volume: 111, Issue:8 Topics: Alginates; Benzimidazoles; Diagnostic Errors; Diet, Reducing; Dietary Fats; Domperidone; Electrodes;	1981
Effect of domperidone on lower esophageal sphincter tone in late pregnancy. Anesthesiology, 1980, Volume: 52, Issue:4 Topics: Adolescent; Adult; Anesthesia, Obstetrical; Benzimidazoles; Domperidone; Esophagogastric Junction; F	1980
[Drug therapy of gastrointestinal motility disorders]. Zhonghua nei ke za zhi, 1995, Volume: 34, Issue:3 Topics: Cisapride; Domperidone; Dyspepsia; Gastroesophageal Reflux; Gastroparesis; Humans; Metoclopramide; P	1995
[Prokinetic drugs in digestive disorders]. La Clinica terapeutica, 1993, Volume: 143, Issue:3 Topics: Antineoplastic Agents; Cisapride; Domperidone; Esophageal Motility Disorders; Gastroesophageal Reflu	1993
Supraesophageal manifestations of gastroesophageal reflux disease. Seminars in gastrointestinal disease, 1999, Volume: 10, Issue:3 Topics: Adult; Anti-Ulcer Agents; Cough; Domperidone; Dopamine Antagonists; Endoscopy, Gastrointestinal; Fem	1999
Clinical evolution of laryngeal granulomas: treatment and prognosis. The Laryngoscope, 1999, Volume: 109, Issue:2 Pt 1 Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Antiemetics; Botulinum Toxins, Type A; Combined Modality	1999
[A severe malaise in infants]. Soins. Gynecologie, obstetrique, puericulture, pediatrie, 1992, Issue:132 Topics: Domperidone; Gastroesophageal Reflux; Humans; Infant; Male; Metoclopramide; Posture	1992
Natural history of gastro-oesophageal reflux disease without oesophagitis. Gut, 1991, Volume: 32, Issue:8 Topics: Adult; Aged; Aluminum Hydroxide; Antacids; Domperidone; Drug Combinations; Esophagitis; Esophagus; F	1991
Self-injury, regurgitation, and antiemetics. Lancet (London, England), 1989, Jan-28, Volume: 1, Issue:8631 Topics: Adult; Domperidone; Down Syndrome; Gastroesophageal Reflux; Humans; Intellectual Disability; Male; M	1989
Sandifer syndrome reconsidered. Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:5 Topics: Antacids; Child; Child, Preschool; Cimetidine; Domperidone; Dystonia; Female; Gastroesophageal Reflu	1989
Summary of the 34th meeting of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee. March 15 and 16, 1989 (omeprazole and domperidone). The American journal of gastroenterology, 1989, Volume: 84, Issue:11 Topics: Animals; Diabetes Complications; Domperidone; Duodenal Ulcer; Gastroesophageal Reflux; Humans; Omepr	1989
[Therapeutic procedures in gastroesophageal reflux disease]. Zeitschrift fur Gastroenterologie, 1986, Volume: 24 Suppl 2 Topics: Alginates; Aluminum Hydroxide; Antacids; Bicarbonates; Combined Modality Therapy; Dilatation; Domper	1986
[Treatment using Motilium of gastro-esophageal reflux associated with respiratory manifestations in children]. Annales de pediatrie, 1989, Volume: 36, Issue:2 Topics: Asthma; Bronchitis; Child; Child, Preschool; Chronic Disease; Cough; Domperidone; Gastroesophageal R	1989
Beneficial effect of omeprazole in a patient with severe bronchial asthma and gastro-oesophageal reflux. The European respiratory journal, 1988, Volume: 1, Issue:10 Topics: Adult; Asthma; Domperidone; Gastroesophageal Reflux; Humans; Male; Omeprazole; Ranitidine; Recurrenc	1988
Increased serum prolactin but normal TSH during prolonged domperidone treatment in children. European journal of pediatrics, 1987, Volume: 146, Issue:2 Topics: Domperidone; Female; Gastroesophageal Reflux; Humans; Infant; Infant, Newborn; Male; Prolactin; Stim	1987
Gastro-oesophageal reflux in infants. Evaluation of treatment by pH monitoring. European journal of pediatrics, 1987, Volume: 146, Issue:5 Topics: Alginates; Aluminum Hydroxide; Bicarbonates; Domperidone; Drug Combinations; Gastric Acidity Determi	1987
[Domperidone peroral therapy for gastroesophageal reflux in severely retarded children]. No to hattatsu = Brain and development, 1986, Volume: 18, Issue:2 Topics: Child; Child, Preschool; Domperidone; Female; Gastroesophageal Reflux; Humans; Infant; Intellectual	1986
[Radionuclide study in the evaluation of the effect of pharmacologic treatment in conditions of esophageal motility pathology]. Minerva chirurgica, 1986, Jul-31, Volume: 41, Issue:13-14 Topics: Domperidone; Esophagogastric Junction; Female; Gastroesophageal Reflux; Humans; Male; Radionuclide I	1986
New drugs in gastroenterology. The Mount Sinai journal of medicine, New York, 1985, Volume: 52, Issue:6 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antidiarrheals; Colit	1985
Effects of domperidone therapy on symptoms and upper gastrointestinal motility in infants with gastroesophageal reflux. The Journal of pediatrics, 1985, Volume: 106, Issue:2 Topics: Domperidone; Drug Administration Schedule; Esophagus; Female; Follow-Up Studies; Gastric Emptying; G	1985
Review of the current status of prokinetic agents in gastroenterology. The American journal of gastroenterology, 1985, Volume: 80, Issue:12 Topics: Benzamides; Chemical Phenomena; Chemistry; Cisapride; Dexamethasone; Digestive System; Domperidone;	1985

domperidone and Gastroesophageal Reflux