domperidone has been researched along with Gastroenteritis in 10 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Gastroenteritis: INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this randomized, double-blind, phase 3 study, children ages 6 months to 12 years with acute gastroenteritis randomly (1:1) received oral domperidone 0." | 9.30 | Safety and Efficacy of Low-dose Domperidone for Treating Nausea and Vomiting Due to Acute Gastroenteritis in Children. ( Appiani, C; Garces-Sanchez, M; Gupta, R; Hu, P; Leitz, G; Li, Q; Mitha, E, 2019) |
| "Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan." | 9.20 | Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan: a multicenter, randomized controlled trial. ( Hinotsu, S; Kawakami, K; Kishida, K; Kita, F; Nakahata, T; Sasaki, H; Shimakawa, T; Urushihara, H; Wakazono, Y; Yamauchi, E; Yorifuji, T, 2015) |
| "To compare the efficacy of ondansetron and domperidone for the symptomatic treatment of vomiting in children with AG who have failed ORT." | 9.15 | Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial. ( Arrighini, A; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Di Pietro, P; Guala, A; Maestro, A; Mannelli, F; Marchetti, F; Messi, G; Pazzaglia, A; Perri, F; Reale, A; Renna, S; Ronfani, L; Rovere, F; Tondelli, MT; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2011) |
| "Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis." | 6.82 | Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial. ( Arrighini, A; Barbi, E; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Guala, A; Maestro, A; Marchetti, F; Mazzoni, E; Pazzaglia, A; Perri, PF; Reale, A; Renna, S; Ronfani, L; Rovere, F; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2016) |
| "In this randomized, double-blind, phase 3 study, children ages 6 months to 12 years with acute gastroenteritis randomly (1:1) received oral domperidone 0." | 5.30 | Safety and Efficacy of Low-dose Domperidone for Treating Nausea and Vomiting Due to Acute Gastroenteritis in Children. ( Appiani, C; Garces-Sanchez, M; Gupta, R; Hu, P; Leitz, G; Li, Q; Mitha, E, 2019) |
| "Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan." | 5.20 | Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan: a multicenter, randomized controlled trial. ( Hinotsu, S; Kawakami, K; Kishida, K; Kita, F; Nakahata, T; Sasaki, H; Shimakawa, T; Urushihara, H; Wakazono, Y; Yamauchi, E; Yorifuji, T, 2015) |
| "To compare the efficacy of ondansetron and domperidone for the symptomatic treatment of vomiting in children with AG who have failed ORT." | 5.15 | Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial. ( Arrighini, A; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Di Pietro, P; Guala, A; Maestro, A; Mannelli, F; Marchetti, F; Messi, G; Pazzaglia, A; Perri, F; Reale, A; Renna, S; Ronfani, L; Rovere, F; Tondelli, MT; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2011) |
| " Ondansetron revealed the largest effect in comparison to placebo for cessation of vomiting (odds ratio = 0." | 5.05 | Antiemetics in Children With Acute Gastroenteritis: A Meta-analysis. ( Acosta-Reyes, J; Florez, ID; Niño-Serna, LF; Veroniki, AA, 2020) |
| "Two girls, aged 2 and 4 years, with acute gastroenteritis and vomiting, received domperidone and metoclopramide, respectively." | 3.73 | [Urinary retention in 2 children after the use of antiemetic agents during acute gastroenteritis]. ( de Moor, RA; Diemont, WL; van den Bemt, PM; Visser, MO, 2005) |
| "Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis." | 2.82 | Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial. ( Arrighini, A; Barbi, E; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Guala, A; Maestro, A; Marchetti, F; Mazzoni, E; Pazzaglia, A; Perri, PF; Reale, A; Renna, S; Ronfani, L; Rovere, F; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2016) |
| "Ondansetron was used in a minor proportion of antiemetic prescriptions (Germany, Canada, Spain, and Italy, 0%; United States, 3%; United Kingdom, 6%)." | 1.35 | Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America. ( Carius, R; Kiess, W; Kostev, K; Pfeil, N; Schröder, H; Uhlig, HH; Uhlig, U, 2008) |
| "Antiemetics are not included for treatment of vomiting associated with acute gastroenteritis (AGE) in children by standard guidelines." | 1.33 | Antiemetics for children with gastroenteritis: off-label but still on in clinical practice. ( Albano, F; Bruzzese, E; De Marco, G; Spagnuolo, MI, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niño-Serna, LF | 1 |
| Acosta-Reyes, J | 1 |
| Veroniki, AA | 1 |
| Florez, ID | 1 |
| Leitz, G | 1 |
| Hu, P | 1 |
| Appiani, C | 1 |
| Li, Q | 1 |
| Mitha, E | 1 |
| Garces-Sanchez, M | 1 |
| Gupta, R | 1 |
| Di Lorenzo, C | 1 |
| Nurko, S | 1 |
| Marchetti, F | 2 |
| Bonati, M | 2 |
| Maestro, A | 2 |
| Zanon, D | 2 |
| Rovere, F | 2 |
| Arrighini, A | 2 |
| Barbi, E | 1 |
| Bertolani, P | 2 |
| Biban, P | 2 |
| Da Dalt, L | 2 |
| Guala, A | 2 |
| Mazzoni, E | 1 |
| Pazzaglia, A | 2 |
| Perri, PF | 1 |
| Reale, A | 2 |
| Renna, S | 2 |
| Urbino, AF | 2 |
| Valletta, E | 2 |
| Vitale, A | 2 |
| Zangardi, T | 2 |
| Clavenna, A | 2 |
| Ronfani, L | 2 |
| Pfeil, N | 1 |
| Uhlig, U | 1 |
| Kostev, K | 1 |
| Carius, R | 1 |
| Schröder, H | 1 |
| Kiess, W | 1 |
| Uhlig, HH | 1 |
| Di Pietro, P | 1 |
| Mannelli, F | 1 |
| Messi, G | 1 |
| Perri, F | 1 |
| Tondelli, MT | 1 |
| Kita, F | 1 |
| Hinotsu, S | 1 |
| Yorifuji, T | 1 |
| Urushihara, H | 1 |
| Shimakawa, T | 1 |
| Kishida, K | 1 |
| Wakazono, Y | 1 |
| Yamauchi, E | 1 |
| Sasaki, H | 1 |
| Nakahata, T | 1 |
| Kawakami, K | 1 |
| de Moor, RA | 1 |
| Diemont, WL | 1 |
| Visser, MO | 1 |
| van den Bemt, PM | 1 |
| Albano, F | 1 |
| Bruzzese, E | 1 |
| Spagnuolo, MI | 1 |
| De Marco, G | 1 |
| Poorter, ME | 1 |
| Wolf, BH | 1 |
| Woltil, HA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group, Prospective Study to Evaluate the Safety and Efficacy of Domperidone in 6-month-old to 12-year-old Pediatric Subjects With Nausea and Vomiting Due to Acute Gastroenteritis[NCT02699385] | Phase 3 | 10 participants (Actual) | Interventional | 2015-12-07 | Terminated (stopped due to Study prematurely terminated upon recommendation of IDMC due to lack of efficacy.) | ||
| Oral Ondansetron vs Domperidone for Symptomatic Treatment of Vomiting During Acute Gastroenteritis in Children: Multicentre Randomized Controlled Trial[NCT01257672] | Phase 3 | 356 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for domperidone and Gastroenteritis
| Article | Year |
|---|---|
Antiemetics in Children With Acute Gastroenteritis: A Meta-analysis.
Topics: Acute Disease; Antiemetics; Child; Child, Preschool; Dexamethasone; Diarrhea; Dimenhydrinate; Domper | 2020 |
4 trials available for domperidone and Gastroenteritis
| Article | Year |
|---|---|
Safety and Efficacy of Low-dose Domperidone for Treating Nausea and Vomiting Due to Acute Gastroenteritis in Children.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Domperidone; Double-Blind | 2019 |
Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Domperidone; Double-Blind | 2016 |
Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Clinical Protocols; Dompe | 2011 |
Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan: a multicenter, randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Domperidone; Drug Therapy | 2015 |
5 other studies available for domperidone and Gastroenteritis
| Article | Year |
|---|---|
It Is Ok to Be Negative!
Topics: Child; Domperidone; Gastroenteritis; Humans; Nausea; Vomiting | 2019 |
Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America.
Topics: Antiemetics; Child; Child, Preschool; Dimenhydrinate; Diphenhydramine; Domperidone; Europe; Female; | 2008 |
[Urinary retention in 2 children after the use of antiemetic agents during acute gastroenteritis].
Topics: Acute Disease; Antiemetics; Child, Preschool; Domperidone; Dopamine Antagonists; Female; Gastroenter | 2005 |
Antiemetics for children with gastroenteritis: off-label but still on in clinical practice.
Topics: Acute Disease; Administration, Rectal; Antiemetics; Child, Preschool; Domperidone; Gastroenteritis; | 2006 |
[A 'suppository for vomiting prevention'].
Topics: Antiemetics; Basal Ganglia Diseases; Child; Child, Preschool; Diagnosis, Differential; Domperidone; | 1997 |