domperidone has been researched along with Gastric Diseases in 29 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A diagnosis of neuroleptic malignant syndrome was made, and the patient was given dantrolene with prompt and complete resolution of all signs and symptoms." | 7.68 | Neuroleptic malignant syndrome induced by domperidone. ( Chan, W; Sachar, DB; Spirt, MJ; Thieberg, M, 1992) |
| "Domperidone is a dopamine antagonist that has recently been released in Canada." | 3.76 | Domperidone, a new dopamine antagonist. ( Champion, MC; Hartnett, M; Yen, M, 1986) |
| " A diagnosis of neuroleptic malignant syndrome was made, and the patient was given dantrolene with prompt and complete resolution of all signs and symptoms." | 3.68 | Neuroleptic malignant syndrome induced by domperidone. ( Chan, W; Sachar, DB; Spirt, MJ; Thieberg, M, 1992) |
| "Domperidone was most effective in those patients with the greatest delay in gastric emptying." | 2.66 | Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy. ( Chatterton, BE; Collins, PJ; Harding, PE; Horowitz, M; Shearman, DJ, 1985) |
| "Domperidone is a selective antagonist at peripheral dopamine D2 receptors, with gastroprokinetic and antiemetic properties." | 2.40 | Domperidone. A review of its use in diabetic gastropathy. ( Prakash, A; Wagstaff, AJ, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (55.17) | 18.7374 |
| 1990's | 11 (37.93) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, XF | 1 |
| Yin, GZ | 1 |
| Liu, QG | 1 |
| Liu, XM | 1 |
| Wang, B | 1 |
| Yu, L | 1 |
| Liu, SN | 1 |
| Cui, HY | 1 |
| Lv, Y | 1 |
| Gordon, SJ | 1 |
| Joseph, RE | 1 |
| Gil, R | 1 |
| Debiais, F | 1 |
| Lefevre, JP | 1 |
| Pouget-Abadie, JF | 1 |
| Marechaud, R | 2 |
| Simmat, G | 1 |
| Boissonnot, L | 1 |
| Valenzuela, JE | 1 |
| Dooley, CP | 1 |
| Reynolds, RP | 1 |
| Bardakjian, BL | 1 |
| Diamant, NE | 1 |
| Abadie, JC | 1 |
| Quéron, B | 1 |
| Ziegler, JE | 1 |
| Sudre, Y | 1 |
| Kendall, BJ | 1 |
| McCallum, RW | 2 |
| Sternberg, A | 1 |
| Coscas, D | 1 |
| Fireman, Z | 1 |
| Czambor-Ksiazek, E | 1 |
| Pokrzywnicki, W | 1 |
| Grzeszczak, W | 1 |
| Duda, G | 1 |
| Prakash, A | 1 |
| Wagstaff, AJ | 1 |
| Lu, F | 1 |
| Wu, H | 1 |
| Zhang, K | 1 |
| Li, D | 1 |
| Bilic, I | 1 |
| Zoricic, I | 1 |
| Anic, T | 1 |
| Separovic, J | 1 |
| Stancic-Rokotov, D | 1 |
| Mikus, D | 1 |
| Buljat, G | 1 |
| Ivankovic, D | 1 |
| Aralica, G | 1 |
| Prkacin, I | 1 |
| Perovic, D | 1 |
| Mise, S | 1 |
| Rotkvic, I | 1 |
| Petek, M | 1 |
| Rucman, R | 1 |
| Seiwerth, S | 1 |
| Sikiric, P | 1 |
| Drenth, JP | 1 |
| Engels, LG | 1 |
| Jian, R | 1 |
| Spirt, MJ | 1 |
| Chan, W | 1 |
| Thieberg, M | 1 |
| Sachar, DB | 1 |
| Layer, P | 1 |
| Goebell, H | 1 |
| Hongo, M | 1 |
| Toyota, T | 1 |
| Hngo, M | 1 |
| Reynolds, JC | 1 |
| Day, JP | 1 |
| Pruitt, RE | 1 |
| Koch, KL | 1 |
| Stern, RM | 1 |
| Stewart, WR | 1 |
| Vasey, MW | 1 |
| Stern, WR | 1 |
| Rogers, AI | 1 |
| Watts, GF | 1 |
| Armitage, M | 1 |
| Sinclair, J | 1 |
| Hill, RD | 1 |
| Ricci, DA | 1 |
| Champion, MC | 1 |
| Hartnett, M | 1 |
| Yen, M | 1 |
| Ceraudo, E | 1 |
| Degano, G | 1 |
| Del Gobbo, MR | 1 |
| Monaco, M | 1 |
| Horowitz, M | 2 |
| Collins, PJ | 2 |
| Shearman, DJ | 2 |
| Harding, PE | 1 |
| Chatterton, BE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oral Domperidone for Relief of Gastrointestinal Disorders in Patients Who Failed Standard Therapy[NCT00761254] | 42 participants (Actual) | Interventional | 2008-08-31 | Terminated (stopped due to PI withdrew due to increased responsibilities in clinical department.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for domperidone and Gastric Diseases
| Article | Year |
|---|---|
Dopamine antagonists in the upper gastrointestinal tract.
Topics: Diabetic Neuropathies; Digestive System; Domperidone; Dopamine Antagonists; Duodenum; Dyspepsia; Eso | 1984 |
Gastroparesis and the current use of prokinetic drugs.
Topics: Cisapride; Domperidone; Gastric Emptying; Humans; Metoclopramide; Piperidines; Stomach Diseases | 1993 |
[Disorders of gastric emptying in diabetes. II. Treatment].
Topics: Cisapride; Diabetes Complications; Domperidone; Dopamine Agents; Erythromycin; Gastric Emptying; Hum | 1997 |
Domperidone. A review of its use in diabetic gastropathy.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Domperidone; Dopamine Antagonists; | 1998 |
Diabetic gastroparesis. A critical reappraisal of new treatment strategies.
Topics: Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Diabetes | 1992 |
[Disorders of gastric emptying].
Topics: Cisapride; Diabetes Complications; Domperidone; Dyspepsia; Gastric Emptying; Gastroesophageal Reflux | 1992 |
Prokinetic agents: a key in the future of gastroenterology.
Topics: Biomechanical Phenomena; Cisapride; Domperidone; Forecasting; Gastroenterology; Gastroesophageal Ref | 1989 |
Diagnosis and treatment of delayed gastric emptying.
Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications; | 1988 |
Domperidone, a new dopamine antagonist.
Topics: Administration, Oral; Adult; Child; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Dys | 1986 |
Disorders of gastric emptying and the application of radionuclide techniques.
Topics: Domperidone; Food; Gastric Emptying; Humans; Indium; Intubation, Gastrointestinal; Metoclopramide; P | 1985 |
3 trials available for domperidone and Gastric Diseases
| Article | Year |
|---|---|
Diabetic gastroparesis. A critical reappraisal of new treatment strategies.
Topics: Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cisapride; Diabetes | 1992 |
Domperidone, a new dopamine antagonist.
Topics: Administration, Oral; Adult; Child; Clinical Trials as Topic; Domperidone; Dopamine Antagonists; Dys | 1986 |
Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropa | 1985 |
18 other studies available for domperidone and Gastric Diseases
| Article | Year |
|---|---|
Does Braun enteroenterostomy reduce delayed gastric emptying after pancreaticoduodenectomy?
Topics: Abdominal Abscess; Acupuncture; Anastomotic Leak; Antiemetics; Domperidone; Enterostomy; Erythromyci | 2014 |
Diabetic gastroparesis and colonic dilatation treated with domperidone.
Topics: Benzimidazoles; Domperidone; Gastrointestinal Hormones; Humans; Motilin; Paralysis; Piperidines; Sto | 1981 |
[Amyloidosis with gastroparesis. Improvement with domperidone].
Topics: Adult; Amyloidosis; Domperidone; Gastric Emptying; Humans; Male; Stomach Diseases | 1984 |
A case of antral tachygastria: symptomatic and myoelectric improvement with gastroenterostomy and domperidone therapy.
Topics: Adult; Domperidone; Electromyography; Female; Gastric Emptying; Gastroenterostomy; Humans; Manometry | 1983 |
[Diabetic gastroparesis treated with domperidone].
Topics: Aged; Diabetic Neuropathies; Domperidone; Female; Gastric Emptying; Humans; Male; Stomach Diseases | 1982 |
[Gastric phytobezoar].
Topics: Adult; Anti-Ulcer Agents; Bezoars; Cellulose; Cisapride; Dietary Fiber; Domperidone; Endoscopy; Frui | 1996 |
[Domperidone and hyperprolactinemia].
Topics: Adult; Domperidone; Female; Gastrointestinal Agents; Humans; Hyperprolactinemia; Middle Aged; Pituit | 1998 |
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromo | 2001 |
Neuroleptic malignant syndrome induced by domperidone.
Topics: Dantrolene; Diabetes Mellitus, Type 1; Domperidone; Female; Humans; Malignant Hyperthermia; Middle A | 1992 |
[Therapy of motility disorders of the stomach and small intestine].
Topics: Cisapride; Constipation; Diarrhea; Domperidone; Dumping Syndrome; Gastric Emptying; Gastrointestinal | 1991 |
[Diabetic gastropathy].
Topics: Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Motility; Humans; Insulin; M | 1991 |
[Effect of acute and long-term administration of a stimulative agent on gastrointestinal motility in the therapy of patients with diabetic gastroparesis].
Topics: Diabetes Complications; Diabetes Mellitus; Domperidone; Female; Gastric Emptying; Humans; Male; Midd | 1990 |
Diabetic gastroparesis in a patient with Parkinson's disease: effective treatment with domperidone.
Topics: Diabetic Neuropathies; Domperidone; Female; Humans; Middle Aged; Parkinson Disease; Stomach Diseases | 1989 |
Gastric emptying and gastric myoelectrical activity in patients with diabetic gastroparesis: effect of long-term domperidone treatment.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Domperidone; Electrophysiology; Female; Gastric Emptying; Hu | 1989 |
Summary of the 34th meeting of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee. March 15 and 16, 1989 (omeprazole and domperidone).
Topics: Animals; Diabetes Complications; Domperidone; Duodenal Ulcer; Gastroesophageal Reflux; Humans; Omepr | 1989 |
Gastric emptying disorders.
Topics: Bethanechol; Bethanechol Compounds; Domperidone; Food; Gastric Emptying; Gastric Fundus; Humans; Met | 1985 |
Treatment of diabetic gastroparesis with oral domperidone.
Topics: Administration, Oral; Adult; Diabetic Neuropathies; Domperidone; Female; Humans; Male; Middle Aged; | 1985 |
[Gastroparesis: which treatment? Presentation of 5 cases and review of the literature].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Domperidone; Female; Gastrointestinal Motility; Humans; | 1986 |