domperidone has been researched along with Disease Models, Animal in 25 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models." | 7.91 | Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019) |
| "L-sulpiride, at a dose of 4 mg/kg, essentially abolished motion-induced emesis in a group of 6 squirrel monkeys undergoing horizontal rotation at 25 rpm, a terrestrial model of space motion sickness (SMS)." | 7.67 | The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness. ( Brizzee, KR; Miller, JD, 1987) |
| "Pretreatment with domperidone inhibited apomorphine-induced kaolin intake." | 5.29 | Pica in rats is analogous to emesis: an animal model in emesis research. ( Hasegawa, S; Matsunaga, T; Morita, M; Takeda, N, 1993) |
| "Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models." | 3.91 | Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019) |
| " Imipramine was administered for the next 5 weeks, and it reversed anhedonia in majority of animals (imipramine-reactive); however, in some animals, it did not (imipramine-non-reactive)." | 3.88 | Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat. ( Antkiewicz-Michaluk, L; Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gruca, P; Kolasa, M; Kuśmider, M; Pabian, P; Papp, M; Romańska, I; Solich, J; Szlachta, M; Żurawek, D, 2018) |
| "Inflammatory edema was induced by carrageenan in male rats, and hyperprolactinemia was induced by injections of the dopamine receptor antagonist domperidone." | 3.76 | Acute and chronic stress and the inflammatory response in hyperprolactinemic rats. ( Carvalho-Freitas, MI; Cruz-Casallas, PE; Felicio, LF; Malucelli, BE; Nasello, AG; Ochoa-Amaya, JE, 2010) |
| " Exposure to moderate and severe hypoxia as well as to hyperoxia and injection of domperidone, a potent peripheral ventilatory stimulant, revealed that the presence of transgenic or rhEpo extensively increased the hypoxic ventilatory response in female mice compared with their corresponding male siblings." | 3.75 | Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin. ( Gassmann, M; Lundby, C; Soliz, J; Soulage, C; Thomsen, JJ, 2009) |
| " Peripheral chemoreceptor effects on ventilation were evaluated by exposing animals to hyperoxia (Dejours test) and domperidone, a peripheral ventilatory stimulant drug directly affecting the carotid sinus nerve discharge." | 3.74 | Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. ( Borter, E; Gassmann, M; Soliz, J; Soulage, C; van Patot, MT, 2008) |
| "L-sulpiride, at a dose of 4 mg/kg, essentially abolished motion-induced emesis in a group of 6 squirrel monkeys undergoing horizontal rotation at 25 rpm, a terrestrial model of space motion sickness (SMS)." | 3.67 | The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness. ( Brizzee, KR; Miller, JD, 1987) |
| "domperidone was administered to both 6-hydroxydopamine Parkinsonism models and regular Wistar rats." | 1.51 | Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone. ( Britto, LRG; Faber, J; Ferraz, HB; Oliveira, LF; Rodrigues, LD; Scorza, CA; Scorza, FA; Shinoda, L, 2019) |
| "Domperidone treatment in intact animals evoked a significant increase in normoxic tidal volume, while haloperidol potentiated tidal volume increase in response to hypoxia." | 1.43 | Hypoxic ventilatory response after dopamine D2 receptor blockade in unilateral rat model of Parkinson's disease. ( Andrzejewski, K; Budzińska, K; Kaczyńska, K; Zaremba, M, 2016) |
| " This model can be used to identify toxic P-gp substrates with altered safety in dog populations and may reduce dog use in safety studies that are part of the drug approval process." | 1.39 | P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion. ( Buckely, LE; Jhingory, MV; Jones, YL; Lancaster, VA; Myers, MJ; Orzechowski, KL; Robl, MG; Swaim, HL; Swain, MD; Tinaza, CA; Yancy, HF, 2013) |
| " New dopamine D4 receptor agonists, exemplified by (E)-1-(4-chlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one O-methyloxime (59a) and (E)-1-(3-chloro-4-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one O-methyloxime (64a), exhibited favorable pharmacokinetic profiles and showed oral bioavailability in rat and dog." | 1.33 | 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction. ( Bhatia, P; Brioni, JD; Chang, R; Donnelly-Roberts, DL; El Kouhen, O; Hakeem, AA; Henry, R; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martino, B; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Patel, MV; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM, 2006) |
| "Pretreatment with domperidone inhibited apomorphine-induced kaolin intake." | 1.29 | Pica in rats is analogous to emesis: an animal model in emesis research. ( Hasegawa, S; Matsunaga, T; Morita, M; Takeda, N, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 12 (48.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kolasa, T | 1 |
| Matulenko, MA | 1 |
| Hakeem, AA | 1 |
| Patel, MV | 1 |
| Mortell, K | 1 |
| Bhatia, P | 1 |
| Henry, R | 1 |
| Nakane, M | 1 |
| Hsieh, GC | 1 |
| Terranova, MA | 1 |
| Uchic, ME | 1 |
| Miller, LN | 1 |
| Chang, R | 1 |
| Donnelly-Roberts, DL | 1 |
| Namovic, MT | 1 |
| Hollingsworth, PR | 1 |
| Martino, B | 1 |
| El Kouhen, O | 1 |
| Marsh, KC | 1 |
| Wetter, JM | 1 |
| Moreland, RB | 1 |
| Brioni, JD | 1 |
| Stewart, AO | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, T | 1 |
| Wang, L | 1 |
| Zhang, L | 2 |
| Li, B | 1 |
| Wang, D | 1 |
| Wang, T | 1 |
| Fu, F | 1 |
| Faron-Górecka, A | 2 |
| Kuśmider, M | 2 |
| Solich, J | 1 |
| Kolasa, M | 2 |
| Pabian, P | 1 |
| Gruca, P | 2 |
| Romańska, I | 1 |
| Żurawek, D | 2 |
| Szlachta, M | 1 |
| Papp, M | 2 |
| Antkiewicz-Michaluk, L | 1 |
| Dziedzicka-Wasylewska, M | 2 |
| Nozu, T | 1 |
| Miyagishi, S | 1 |
| Kumei, S | 1 |
| Nozu, R | 1 |
| Takakusaki, K | 1 |
| Okumura, T | 1 |
| Rodrigues, LD | 1 |
| Oliveira, LF | 1 |
| Shinoda, L | 1 |
| Scorza, CA | 1 |
| Faber, J | 1 |
| Ferraz, HB | 1 |
| Britto, LRG | 1 |
| Scorza, FA | 1 |
| Stegner, D | 1 |
| Thielmann, I | 1 |
| Kraft, P | 1 |
| Frohman, MA | 1 |
| Stoll, G | 1 |
| Nieswandt, B | 1 |
| Andrzejewski, K | 1 |
| Budzińska, K | 1 |
| Zaremba, M | 1 |
| Kaczyńska, K | 1 |
| Chang, X | 1 |
| Wang, S | 1 |
| Bao, YR | 1 |
| Li, TJ | 1 |
| Yu, XM | 1 |
| Meng, XS | 1 |
| Soliz, J | 2 |
| Soulage, C | 2 |
| Borter, E | 1 |
| van Patot, MT | 1 |
| Gassmann, M | 2 |
| King, MV | 1 |
| Seeman, P | 2 |
| Marsden, CA | 1 |
| Fone, KC | 1 |
| Thomsen, JJ | 1 |
| Lundby, C | 1 |
| Novak, G | 1 |
| Ochoa-Amaya, JE | 1 |
| Malucelli, BE | 1 |
| Cruz-Casallas, PE | 1 |
| Nasello, AG | 1 |
| Felicio, LF | 1 |
| Carvalho-Freitas, MI | 1 |
| Zhao, T | 1 |
| Zondervan-van der Linde, H | 1 |
| Severijnen, LA | 1 |
| Oostra, BA | 1 |
| Willemsen, R | 1 |
| Bonifati, V | 1 |
| Swain, MD | 1 |
| Orzechowski, KL | 1 |
| Swaim, HL | 1 |
| Jones, YL | 1 |
| Robl, MG | 1 |
| Tinaza, CA | 1 |
| Myers, MJ | 1 |
| Jhingory, MV | 1 |
| Buckely, LE | 1 |
| Lancaster, VA | 1 |
| Yancy, HF | 1 |
| Kuribayashi, K | 1 |
| Kitaoka, Y | 2 |
| Kumai, T | 1 |
| Munemasa, Y | 1 |
| Isenoumi, K | 1 |
| Motoki, M | 1 |
| Kogo, J | 1 |
| Hayashi, Y | 1 |
| Kobayashi, S | 1 |
| Ueno, S | 1 |
| Schlenker, EH | 1 |
| Takeda, N | 1 |
| Hasegawa, S | 1 |
| Morita, M | 1 |
| Matsunaga, T | 1 |
| Bilic, I | 1 |
| Zoricic, I | 1 |
| Anic, T | 1 |
| Separovic, J | 1 |
| Stancic-Rokotov, D | 1 |
| Mikus, D | 1 |
| Buljat, G | 1 |
| Ivankovic, D | 1 |
| Aralica, G | 1 |
| Prkacin, I | 1 |
| Perovic, D | 1 |
| Mise, S | 1 |
| Rotkvic, I | 1 |
| Petek, M | 1 |
| Rucman, R | 1 |
| Seiwerth, S | 1 |
| Sikiric, P | 1 |
| Herak-Perković, V | 1 |
| Grabarević, Z | 1 |
| Banić, M | 1 |
| Anić, B | 1 |
| Novosel, V | 1 |
| Pogacnik, M | 1 |
| Chiou, GC | 1 |
| Chen, YJ | 1 |
| Miller, JD | 1 |
| Brizzee, KR | 1 |
25 other studies available for domperidone and Disease Models, Animal
| Article | Year |
|---|---|
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Topics: Animals; Benzamides; Binding Sites; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Drug | 2006 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system.
Topics: Analgesics; Animals; Carrageenan; Corpus Striatum; Disease Models, Animal; Domperidone; Dopamine; Do | 2021 |
Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat.
Topics: Anhedonia; Animals; Antidepressive Agents; Autoradiography; Brain; Depression; Disease Models, Anima | 2018 |
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagon | 2019 |
Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone.
Topics: Animals; Behavior, Animal; Cardiovascular Diseases; Disease Models, Animal; Domperidone; Dopamine An | 2019 |
Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.
Topics: Animals; Blood Platelets; Carotid Artery Diseases; Disease Models, Animal; Domperidone; Dose-Respons | 2013 |
Hypoxic ventilatory response after dopamine D2 receptor blockade in unilateral rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Disease Mode | 2016 |
Multicomponent, multitarget integrated adjustment - Metabolomics study of Qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine.
Topics: Animals; Atropine; Benzamides; Biomarkers; Chromatography, High Pressure Liquid; Chromatography, Liq | 2016 |
Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice.
Topics: Acclimatization; Acute Disease; Animals; Body Temperature; Carotid Body; Chronic Disease; Disease Mo | 2008 |
Increased dopamine D2High receptors in rats reared in social isolation.
Topics: Animals; Behavior, Animal; Binding, Competitive; Brain Chemistry; Corpus Striatum; Disease Models, A | 2009 |
Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin.
Topics: Adaptation, Physiological; Adult; Animals; Brain Stem; Catecholamines; Disease Models, Animal; Dompe | 2009 |
Hyperactive mice show elevated D2(High) receptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corpus Striatum; Disease | 2010 |
Acute and chronic stress and the inflammatory response in hyperprolactinemic rats.
Topics: Acute Disease; Animals; Carrageenan; Chronic Disease; Cold Temperature; Disease Models, Animal; Domp | 2010 |
Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish.
Topics: Animals; Apomorphine; Body Patterning; Brain; Disease Models, Animal; Domperidone; Dopamine; Dopamin | 2012 |
P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.
Topics: Animals; Anti-Infective Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette | 2013 |
Mesolimbic dopamine D₂ receptor plasticity contributes to stress resilience in rats subjected to chronic mild stress.
Topics: Animals; Brain; Depression; Disease Models, Animal; Domperidone; Gene Expression Regulation; Male; R | 2013 |
Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina.
Topics: Analysis of Variance; Animals; Antibodies; Atrial Natriuretic Factor; Benzazepines; Blotting, Wester | 2006 |
In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia.
Topics: Animals; Body Temperature; Carbon Dioxide; Carotid Body; Cricetinae; Disease Models, Animal; Domperi | 2007 |
Pica in rats is analogous to emesis: an animal model in emesis research.
Topics: Animals; Antiemetics; Apomorphine; Cisplatin; Copper; Copper Sulfate; Disease Models, Animal; Domper | 1993 |
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromo | 2001 |
Effects of dopaminergic drugs on inflammatory bowel disease induced with 2,4-dinitrofluorbenzene in BALB/c mice.
Topics: Animals; Bromocriptine; Colon; Dinitrofluorobenzene; Disease Models, Animal; Domperidone; Dopamine A | 2001 |
Effects of dopamine agonist, bromocriptine, and some dopamine antagonists on ocular blood flow.
Topics: Animals; Blood Flow Velocity; Bromocriptine; Disease Models, Animal; Domperidone; Dopamine Antagonis | 1992 |
The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness.
Topics: Animals; Antiemetics; Chlorpromazine; Disease Models, Animal; Domperidone; Female; Male; Motion Sick | 1987 |