domperidone has been researched along with Disease Exacerbation in 2 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone treatment increased LPS-induced tumor necrosis factor (TNF) and interleukin (IL)-6 production in the bronchoalveolar lavage fluid, without altering tissue damage and the number of immune cells in the lungs and circulation." | 5.48 | Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice. ( Barreto, TR; Costola-de-Souza, C; Felício, LF; Margatho, RO; Palermo-Neto, J; Queiroz-Hazarbassanov, N; Rodrigues, SC; Zager, A, 2018) |
| "Domperidone treatment increased LPS-induced tumor necrosis factor (TNF) and interleukin (IL)-6 production in the bronchoalveolar lavage fluid, without altering tissue damage and the number of immune cells in the lungs and circulation." | 1.48 | Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice. ( Barreto, TR; Costola-de-Souza, C; Felício, LF; Margatho, RO; Palermo-Neto, J; Queiroz-Hazarbassanov, N; Rodrigues, SC; Zager, A, 2018) |
| "Those ascribed to gastroesophageal reflux and vocal abuse have a high resolution rate, although some cases need rescue procedures." | 1.30 | Clinical evolution of laryngeal granulomas: treatment and prognosis. ( De Biase, NG; de Lima Pontes, PA; Gadelha, EC, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barreto, TR | 1 |
| Costola-de-Souza, C | 1 |
| Margatho, RO | 1 |
| Queiroz-Hazarbassanov, N | 1 |
| Rodrigues, SC | 1 |
| Felício, LF | 1 |
| Palermo-Neto, J | 1 |
| Zager, A | 1 |
| de Lima Pontes, PA | 1 |
| De Biase, NG | 1 |
| Gadelha, EC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial Comparing Proton Pump Inhibitor Therapy With and Without Interarytenoid Botulinum Toxin Injection for Vocal Fold Granuloma[NCT01678053] | Phase 2 | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn (stopped due to Was not able to recruit patients for randomization.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for domperidone and Disease Exacerbation
| Article | Year |
|---|---|
Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Progression; Domperidone; Dopamine | 2018 |
Clinical evolution of laryngeal granulomas: treatment and prognosis.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Antiemetics; Botulinum Toxins, Type A; Combined Modality | 1999 |