domperidone has been researched along with Diabetic Neuropathies in 10 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone was most effective in those patients with the greatest delay in gastric emptying." | 2.66 | Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy. ( Chatterton, BE; Collins, PJ; Harding, PE; Horowitz, M; Shearman, DJ, 1985) |
| " Administration of domperidone for 3 days reduced the falls in creatinine clearance and the urinary excretion of sodium and potassium induced by UP but did not alter the blood pressure and aldosterone dose-response curves to angiotensin II." | 1.27 | Peripheral dopaminergic blockade for the treatment of diabetic orthostatic hypotension. ( Andriolo, A; Chacra, AR; Lopes de Faria, SR; Ribeiro, AB; Zanella, MT, 1988) |
| "Domperidone did not increase solid oesophageal emptying in diabetic patients either after acute or after chronic administration." | 1.27 | The effect of domperidone on oesophageal emptying in diabetic autonomic neuropathy. ( Horowitz, M; Jamieson, GG; Maddern, GJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valenzuela, JE | 1 |
| Dooley, CP | 1 |
| Maréchaud, R | 1 |
| Abadie, JC | 1 |
| Quéron, B | 1 |
| Ziegler, JE | 1 |
| Sudre, Y | 1 |
| Horowitz, M | 3 |
| O'Donovan, D | 1 |
| Jones, KL | 1 |
| Feinle, C | 1 |
| Rayner, CK | 1 |
| Samsom, M | 1 |
| Champion, MC | 1 |
| Day, JP | 1 |
| Pruitt, RE | 1 |
| Watts, GF | 1 |
| Armitage, M | 1 |
| Sinclair, J | 1 |
| Hill, RD | 1 |
| Lopes de Faria, SR | 1 |
| Zanella, MT | 1 |
| Andriolo, A | 1 |
| Ribeiro, AB | 1 |
| Chacra, AR | 1 |
| Destee, A | 1 |
| Leys, D | 1 |
| Delisse, B | 1 |
| Warot, P | 1 |
| Harding, PE | 1 |
| Chatterton, BE | 1 |
| Collins, PJ | 1 |
| Shearman, DJ | 1 |
| Maddern, GJ | 1 |
| Jamieson, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Preoperative Oral Carbohydrate on Recovery in Diabetic Patients After Gastrointestinal Surgery: a Pilot Randomized Controlled Trial[NCT03204344] | 65 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for domperidone and Diabetic Neuropathies
| Article | Year |
|---|---|
Dopamine antagonists in the upper gastrointestinal tract.
Topics: Diabetic Neuropathies; Digestive System; Domperidone; Dopamine Antagonists; Duodenum; Dyspepsia; Eso | 1984 |
Gastric emptying in diabetes: clinical significance and treatment.
Topics: Blood Glucose; Cisapride; Diabetes Mellitus; Diabetic Neuropathies; Domperidone; Gastric Emptying; G | 2002 |
Management of idiopathic, diabetic and miscellaneous gastroparesis with cisapride.
Topics: Cisapride; Clinical Trials as Topic; Diabetic Neuropathies; Domperidone; Gastric Emptying; Humans; M | 1989 |
2 trials available for domperidone and Diabetic Neuropathies
| Article | Year |
|---|---|
Management of idiopathic, diabetic and miscellaneous gastroparesis with cisapride.
Topics: Cisapride; Clinical Trials as Topic; Diabetic Neuropathies; Domperidone; Gastric Emptying; Humans; M | 1989 |
Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropa | 1985 |
6 other studies available for domperidone and Diabetic Neuropathies
| Article | Year |
|---|---|
[Diabetic gastroparesis treated with domperidone].
Topics: Aged; Diabetic Neuropathies; Domperidone; Female; Gastric Emptying; Humans; Male; Stomach Diseases | 1982 |
Diabetic gastroparesis in a patient with Parkinson's disease: effective treatment with domperidone.
Topics: Diabetic Neuropathies; Domperidone; Female; Humans; Middle Aged; Parkinson Disease; Stomach Diseases | 1989 |
Treatment of diabetic gastroparesis with oral domperidone.
Topics: Administration, Oral; Adult; Diabetic Neuropathies; Domperidone; Female; Humans; Male; Middle Aged; | 1985 |
Peripheral dopaminergic blockade for the treatment of diabetic orthostatic hypotension.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Diabetic Neuropathies; Diet; Domperidone; Female | 1988 |
Orthostatic hypotension due to diabetic autonomic neuropathy? Treatment with domperidone.
Topics: Aged; Diabetic Neuropathies; Domperidone; Female; Humans; Hypotension, Orthostatic; Receptors, Dopam | 1987 |
The effect of domperidone on oesophageal emptying in diabetic autonomic neuropathy.
Topics: Adult; Autonomic Nervous System; Diabetic Neuropathies; Domperidone; Esophagus; Female; Humans; Male | 1985 |