domperidone has been researched along with Diabetes Mellitus in 7 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe the health-related quality of life (HRQOL) of patients with insulin-treated diabetes and symptoms of diabetic gastroparesis and to assess the impact of domperidone on HRQOL in these patients." | 9.08 | Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis. ( Farup, CE; Helbers, L; Leidy, NK; Murray, M; Quigley, EM; Williams, GR, 1998) |
| "There is increased awareness about risks and benefits of using domperidone to treat gastroparesis." | 7.83 | Domperidone to Treat Symptoms of Gastroparesis: Benefits and Side Effects from a Large Single-Center Cohort. ( Midani, D; Parkman, HP; Parupalli, R; Roberts, AC; Saadi, M; Schey, R, 2016) |
| " The included RCTs were small (total of 28 participants in RCTs), short term (two to three weeks), only examined fludrocortisone for orthostatic hypotension in people with two conditions (diabetes and Parkinson disease), and had variable risk of bias (two had unclear risk of bias and one had low risk of bias)." | 5.12 | Fludrocortisone for orthostatic hypotension. ( Ansari, Y; Chung, KA; Gibbons, CH; Helfand, M; Peterson, K; Raj, SR; Veazie, S, 2021) |
| "To describe the health-related quality of life (HRQOL) of patients with insulin-treated diabetes and symptoms of diabetic gastroparesis and to assess the impact of domperidone on HRQOL in these patients." | 5.08 | Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis. ( Farup, CE; Helbers, L; Leidy, NK; Murray, M; Quigley, EM; Williams, GR, 1998) |
| "To review the pharmacology, pharmacokinetics, efficacy, and safety of domperidone in the treatment of gastrointestinal motility disorders and emesis." | 4.80 | Domperidone: a peripherally acting dopamine2-receptor antagonist. ( Barone, JA, 1999) |
| "There is increased awareness about risks and benefits of using domperidone to treat gastroparesis." | 3.83 | Domperidone to Treat Symptoms of Gastroparesis: Benefits and Side Effects from a Large Single-Center Cohort. ( Midani, D; Parkman, HP; Parupalli, R; Roberts, AC; Saadi, M; Schey, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Veazie, S | 1 |
| Peterson, K | 1 |
| Ansari, Y | 1 |
| Chung, KA | 1 |
| Gibbons, CH | 1 |
| Raj, SR | 1 |
| Helfand, M | 1 |
| Schey, R | 1 |
| Saadi, M | 1 |
| Midani, D | 1 |
| Roberts, AC | 1 |
| Parupalli, R | 1 |
| Parkman, HP | 1 |
| Johannes, CB | 1 |
| Varas-Lorenzo, C | 1 |
| McQuay, LJ | 1 |
| Midkiff, KD | 1 |
| Fife, D | 1 |
| Farup, CE | 1 |
| Leidy, NK | 1 |
| Murray, M | 1 |
| Williams, GR | 1 |
| Helbers, L | 1 |
| Quigley, EM | 1 |
| Barone, JA | 1 |
| Horowitz, M | 1 |
| O'Donovan, D | 1 |
| Jones, KL | 1 |
| Feinle, C | 1 |
| Rayner, CK | 1 |
| Samsom, M | 1 |
| Hngo, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy[NCT00103597] | Phase 1 | 50 participants | Interventional | 2005-01-31 | Completed | ||
| An Investigational New Drug Program for the Use of Domperidone in the Treatment of Refractory Gastroesophageal Reflux Disease and Other Gastrointestinal Motility Disorders[NCT00777439] | 75 participants (Anticipated) | Interventional | 2008-10-31 | Recruiting | |||
| Oral Domperidone for Relief of Gastrointestinal Disorders in Patients Who Failed Standard Therapy[NCT00761254] | 42 participants (Actual) | Interventional | 2008-08-31 | Terminated (stopped due to PI withdrew due to increased responsibilities in clinical department.) | |||
| Impact of Preoperative Oral Carbohydrate on Recovery in Diabetic Patients After Gastrointestinal Surgery: a Pilot Randomized Controlled Trial[NCT03204344] | 65 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for domperidone and Diabetes Mellitus
| Article | Year |
|---|---|
Fludrocortisone for orthostatic hypotension.
Topics: Bias; Diabetes Mellitus; Domperidone; Dysautonomia, Familial; Fludrocortisone; Humans; Hypotension, | 2021 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Gastric emptying in diabetes: clinical significance and treatment.
Topics: Blood Glucose; Cisapride; Diabetes Mellitus; Diabetic Neuropathies; Domperidone; Gastric Emptying; G | 2002 |
1 trial available for domperidone and Diabetes Mellitus
| Article | Year |
|---|---|
Effect of domperidone on the health-related quality of life of patients with symptoms of diabetic gastroparesis.
Topics: Adult; Aged; Antiemetics; Diabetes Complications; Diabetes Mellitus; Domperidone; Double-Blind Metho | 1998 |
3 other studies available for domperidone and Diabetes Mellitus
| Article | Year |
|---|---|
Domperidone to Treat Symptoms of Gastroparesis: Benefits and Side Effects from a Large Single-Center Cohort.
Topics: Adult; Cohort Studies; Diabetes Complications; Diabetes Mellitus; Diarrhea; Domperidone; Dopamine An | 2016 |
Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Contro | 2010 |
[Effect of acute and long-term administration of a stimulative agent on gastrointestinal motility in the therapy of patients with diabetic gastroparesis].
Topics: Diabetes Complications; Diabetes Mellitus; Domperidone; Female; Gastric Emptying; Humans; Male; Midd | 1990 |