domperidone has been researched along with Dementia Praecox in 9 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although all current antipsychotics act by interfering with the action of dopamine at dopamine D2 receptors, two recent reports showed that 800 to 1000 mg of cannabidiol per day alleviated the signs and symptoms of schizophrenia, although cannabidiol is not known to act on dopamine receptors." | 3.83 | Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose. ( Seeman, P, 2016) |
| " Repeated early morning trough measures of plasma clozapine and prolactin levels on each subject were studied during the course of a double-blind dose-response clozapine study." | 2.71 | Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment. ( de Leon, J; Diaz, FJ; Josiassen, RC; Simpson, GM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Thiagarajan, SK | 1 |
| Mok, SY | 1 |
| Ogawa, S | 1 |
| Parhar, IS | 1 |
| Tang, PY | 1 |
| Seeman, P | 3 |
| King, MV | 1 |
| Marsden, CA | 1 |
| Fone, KC | 1 |
| Novak, G | 1 |
| de Leon, J | 1 |
| Diaz, FJ | 1 |
| Josiassen, RC | 1 |
| Simpson, GM | 1 |
| Nerozzi, D | 2 |
| Magnani, A | 2 |
| Dastoli, C | 1 |
| Ferri, E | 1 |
| Capesciotti, G | 1 |
| Antonozzi, I | 2 |
| Frajese, G | 2 |
| Meltzer, HY | 2 |
| Konicki, PE | 1 |
| Owen, RR | 1 |
| Litman, RE | 1 |
| Pickar, D | 1 |
| Sforza, V | 1 |
| Scaramucci, E | 1 |
| Cerilli, M | 1 |
| Moretti, C | 1 |
| Zlobina, GP | 1 |
| Chekalina, ND | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Controlled Pilot Trial of Domperidone in Relapsing-Remitting Multiple Sclerosis[NCT02493049] | Phase 2 | 17 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for domperidone and Dementia Praecox
| Article | Year |
|---|---|
Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Domperidone; Double-Blind Method; F | 2004 |
8 other studies available for domperidone and Dementia Praecox
| Article | Year |
|---|---|
Integrative Roles of Dopamine Pathway and Calcium Channels Reveal a Link between Schizophrenia and Opioid Use Disorder.
Topics: Animals; Calcium Channels; Domperidone; Dopamine; Dopamine Antagonists; Dopaminergic Neurons; Locomo | 2023 |
Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Cannabidiol; Domperidone; Dose-Response | 2016 |
Increased dopamine D2High receptors in rats reared in social isolation.
Topics: Animals; Behavior, Animal; Binding, Competitive; Brain Chemistry; Corpus Striatum; Disease Models, A | 2009 |
Hyperactive mice show elevated D2(High) receptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corpus Striatum; Disease | 2010 |
Prolactin responses to domperidone in chronic schizophrenia.
Topics: Aged; Chronic Disease; Domperidone; Humans; Male; Middle Aged; Prolactin; Psychiatric Status Rating | 1992 |
The acute effects of central- and peripheral-acting dopamine antagonists on plasma HVA in schizophrenic patients.
Topics: Adult; Debrisoquin; Domperidone; Female; Fluphenazine; Homovanillic Acid; Humans; Male; Receptors, D | 1991 |
Plasma prolactin response to domperidone in acute schizophrenia and schizophreniform illness.
Topics: Acute Disease; Adult; Brain; Domperidone; Humans; Male; Military Personnel; Prolactin; Psychotic Dis | 1990 |
[Specific binding of 3H-domperidone--a selective ligand of D2-dopamine receptors--by the human caudate nucleus].
Topics: Aged; Caudate Nucleus; Domperidone; Dose-Response Relationship, Drug; Humans; Ligands; Middle Aged; | 1987 |