domperidone has been researched along with Death, Sudden, Cardiac in 38 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We systematically searched MEDLINE, PubMed, EMBASE, Scopus and CINAHL Plus to identify observational studies examining the association of domperidone and sudden cardiac death and/or ventricular arrhythmia." | 9.12 | Domperidone and the risks of sudden cardiac death and ventricular arrhythmia: A systematic review and meta-analysis of observational studies. ( Douros, A; Filion, KB; Moriello, C; Ou, LB, 2021) |
| "The first author performed EMBASE, PubMed and Scopus searches to identify human studies assessing the association between current domperidone exposure and cardiac arrhythmia or sudden death." | 8.93 | Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis. ( Holcombe, A; Leelakanok, N; Schweizer, ML, 2016) |
| "The results of two large epidemiological studies on the association between domperidone and ventricular arrhythmia or sudden cardiac death were published in 2015; one study was conducted in Taiwan and the other in the United Kingdom." | 7.83 | Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia. ( , 2016) |
| "Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders." | 6.46 | Domperidone and long QT syndrome. ( Giorgi, G; Rossi, M, 2010) |
| "We systematically searched MEDLINE, PubMed, EMBASE, Scopus and CINAHL Plus to identify observational studies examining the association of domperidone and sudden cardiac death and/or ventricular arrhythmia." | 5.12 | Domperidone and the risks of sudden cardiac death and ventricular arrhythmia: A systematic review and meta-analysis of observational studies. ( Douros, A; Filion, KB; Moriello, C; Ou, LB, 2021) |
| " From these publications, it cannot be concluded that domperidone exposure definitely increases the risk of "sudden cardiac death", "death associated with ventricular arrhythmia" or "ventricular arrhythmia" The most concrete result of these studies is that the risk is higher with metoclopramide exposure compared to domperidone exposure." | 5.01 | Critical review of European Medicines Agency (EMA) assessment report and related literature on domperidone. ( Tuğlular, I; Yüksel, K, 2019) |
| "The first author performed EMBASE, PubMed and Scopus searches to identify human studies assessing the association between current domperidone exposure and cardiac arrhythmia or sudden death." | 4.93 | Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis. ( Holcombe, A; Leelakanok, N; Schweizer, ML, 2016) |
| "To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer." | 4.91 | [Cardiac adverse effects of domperidone in adult patients: a systematic review]. ( Avila, A; Caraballo, L; Marzi, M; Molina, G; Piskulic, L; Weitz, D, 2015) |
| "A search of two bibliographic databases, the European Medicines Agency (EMA) website, Micromedex, Lexicomp and reference texts was undertaken for domperidone related reports of QT prolongation, cardiac arrhythmias and/or SCD." | 4.91 | Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations. ( Buffery, PJ; Strother, RM, 2015) |
| "Risk-minimization measures (RMM), including label revisions were implemented in Europe for domperidone because of evidence of increased incidence of cardiac arrhythmia and sudden cardiac death." | 3.91 | Awareness of, and Compliance with, Domperidone Revised Labeling After a Risk-Minimization Activity in Europe. ( Fife, D; Hu, P; Kaplan, S; Oliveria, SA; Phillips, S; Richarz, U; Waller, J, 2019) |
| "Observational retrospective studies have linked domperidone and prolonged QT interval, ventricular arrhythmias and risk of sudden death." | 3.85 | [Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database]. ( Auffret, M; Béné, J; Gautier, S; Rochoy, M, 2017) |
| "The results of two large epidemiological studies on the association between domperidone and ventricular arrhythmia or sudden cardiac death were published in 2015; one study was conducted in Taiwan and the other in the United Kingdom." | 3.83 | Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia. ( , 2016) |
| " In 2012, Health Canada released a warning regarding domperidone use, based on associations with life-threatening arrhythmias and death." | 3.83 | Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a "Black Box" Warning: A Canadian Tertiary Care Center Study. ( Al-Dabbagh, R; Cooray, M; Forbes, N; Liu, LW; Tse, F; Xenodemetropoulos, T; Yuan, Y, 2016) |
| "The risk of sudden cardiac death (SCD) can be increased with the use of drugs." | 3.01 | Drug-induced Sudden Death: A Scoping Review. ( Amaro-Hosey, K; Blanco-Silvente, L; Capellà, D; Castells, X; Loma-Osorio, P, 2023) |
| "Domperidone is a proposed treatment of orthostatic hypotension (OH) in Parkinson's disease (PD)." | 2.55 | Domperidone for Hypotension in Parkinson's Disease: A Systematic Review. ( Bacchi, S; Chim, I; Kramer, P; Postuma, RB, 2017) |
| "Domperidone is an antiemetic drug with relatively few side-effects." | 2.49 | [Domperidone and the risk of sudden cardiac death]. ( Belle-van Meerkerk, G; Muller, AF; van de Ree, MA; van Roeden, SE; van Tuyl, SA, 2013) |
| "Domperidone is a prokinetic agent widely prescribed in adults and children with gastrointestinal disorders." | 2.46 | Domperidone and long QT syndrome. ( Giorgi, G; Rossi, M, 2010) |
| "Domperidone was prescribed among 1438 deliveries at a rate of 1." | 1.48 | Domperidone for insufficient lactation in England 2002-2015: A drug utilization study with interrupted time series analysis. ( Filion, KB; Mehrabadi, A; Platt, RW; Reynier, P, 2018) |
| "Domperidone has been used as a galactagogue; however, solid evidence from an adequate sized randomized clinical trial is missing." | 1.46 | Should Domperidone be Used as a Galactagogue? Possible Safety Implications for Mother and Child. ( Hondeghem, LM; Logghe, NH, 2017) |
| "Domperidone use may increase the risk of VT/SCD in patients with PD, particularly those with a history of cardiovascular disease." | 1.43 | Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease. ( Blais, L; Bugden, S; Dell'Aniello, S; Dormuth, C; Ernst, P; Evans, C; Khairy, P; Marras, C; Renoux, C; Steele, R; Tamim, H; Turin, TC, 2016) |
| "The phenomenon of sudden cardiac death is usually related to the worsening of existing heart conditions leading to ventricular arrhythmia (VA)." | 1.42 | A case of sudden cardiac death following Domperidone self-medication. ( De Leo, D; Fais, P; Gottardo, R; Laposata, C; Lockwood, R; Vermiglio, E, 2015) |
| "Out-of-hospital sudden cardiac death was assessed by linkage with Hospital Episode Statistics and death certificates." | 1.42 | Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study. ( Arana, A; Fife, D; Johannes, CB; McQuay, LJ; Rothman, KJ; Varas-Lorenzo, C, 2015) |
| "Domperidone is a dopamine antagonist with anti-nausea and anti-emetic activity." | 1.37 | Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death. ( Hondeghem, LM, 2011) |
| "Recently, a 4-fold increase in risk of sudden cardiac death (SCD) was reported for domperidone in a study that focused on corrected QT interval (QTc)-prolonging drugs as a class and their association with SCD." | 1.36 | Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands. ( Dieleman, JP; Sturkenboom, MC; van Herpen, G; van Noord, C; Verhamme, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 31 (81.58) | 24.3611 |
| 2020's | 4 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Nakhlé, G | 1 |
| Brophy, JM | 1 |
| Renoux, C | 3 |
| Khairy, P | 2 |
| Bélisle, P | 1 |
| LeLorier, J | 1 |
| Amaro-Hosey, K | 1 |
| Castells, X | 1 |
| Blanco-Silvente, L | 1 |
| Loma-Osorio, P | 1 |
| Capellà, D | 1 |
| Doyle, CM | 1 |
| Lix, LM | 1 |
| Hemmelgarn, BR | 1 |
| Paterson, JM | 1 |
| Ou, LB | 1 |
| Moriello, C | 1 |
| Douros, A | 1 |
| Filion, KB | 2 |
| Grzeskowiak, LE | 2 |
| Smithers, LG | 1 |
| Smolina, K | 1 |
| Morgan, S | 1 |
| Mintzes, B | 1 |
| Hanley, G | 1 |
| Oberlander, T | 1 |
| Berger, F | 1 |
| Saâïd, S | 1 |
| van Gelder, T | 1 |
| Stricker, B | 1 |
| Becker, M | 1 |
| van den Bemt, P | 1 |
| Bacchi, S | 1 |
| Chim, I | 1 |
| Kramer, P | 1 |
| Postuma, RB | 1 |
| Mehrabadi, A | 1 |
| Reynier, P | 1 |
| Platt, RW | 1 |
| Yüksel, K | 1 |
| Tuğlular, I | 1 |
| Fife, D | 3 |
| Waller, J | 1 |
| Kaplan, S | 1 |
| Hu, P | 1 |
| Phillips, S | 1 |
| Oliveria, SA | 1 |
| Richarz, U | 1 |
| van Roeden, SE | 1 |
| Belle-van Meerkerk, G | 1 |
| van Tuyl, SA | 1 |
| van de Ree, MA | 1 |
| Muller, AF | 1 |
| Otten, MH | 1 |
| Benkimoun, P | 1 |
| Amir, LH | 1 |
| Grzeskowiak, L | 1 |
| Hill, C | 1 |
| Nicot, P | 1 |
| Piette, C | 1 |
| Le Gleut, K | 1 |
| Durand, G | 1 |
| Toussaint, B | 1 |
| Marzi, M | 1 |
| Weitz, D | 1 |
| Avila, A | 1 |
| Molina, G | 1 |
| Caraballo, L | 1 |
| Piskulic, L | 1 |
| Buffery, PJ | 1 |
| Strother, RM | 1 |
| Fais, P | 1 |
| Vermiglio, E | 1 |
| Laposata, C | 1 |
| Lockwood, R | 1 |
| Gottardo, R | 1 |
| De Leo, D | 1 |
| Arana, A | 1 |
| Johannes, CB | 2 |
| McQuay, LJ | 2 |
| Varas-Lorenzo, C | 2 |
| Rothman, KJ | 1 |
| Leelakanok, N | 1 |
| Holcombe, A | 1 |
| Schweizer, ML | 1 |
| Scorza, FA | 1 |
| Scorza, CA | 1 |
| Ferraz, HB | 1 |
| Dell'Aniello, S | 1 |
| Marras, C | 1 |
| Bugden, S | 1 |
| Turin, TC | 1 |
| Blais, L | 1 |
| Tamim, H | 1 |
| Evans, C | 1 |
| Steele, R | 1 |
| Dormuth, C | 1 |
| Ernst, P | 1 |
| Forbes, N | 1 |
| Cooray, M | 1 |
| Al-Dabbagh, R | 1 |
| Yuan, Y | 1 |
| Tse, F | 1 |
| Liu, LW | 1 |
| Xenodemetropoulos, T | 1 |
| Hondeghem, LM | 3 |
| Logghe, NH | 1 |
| Rochoy, M | 1 |
| Auffret, M | 1 |
| Béné, J | 1 |
| Gautier, S | 1 |
| Hennessy, S | 1 |
| Leonard, CE | 1 |
| Palumbo, CM | 1 |
| Bilker, WB | 1 |
| Newcomb, C | 1 |
| Kimmel, SE | 1 |
| Rossi, M | 1 |
| Giorgi, G | 1 |
| Midkiff, KD | 1 |
| van Noord, C | 1 |
| Dieleman, JP | 1 |
| van Herpen, G | 1 |
| Verhamme, K | 1 |
| Sturkenboom, MC | 1 |
| Bozzo, P | 1 |
| Koren, G | 1 |
| Ito, S | 1 |
| Michaud, V | 1 |
| Turgeon, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Domperidone Use in Parkinson's Disease and Risk of Sudden Cardiac Death[NCT02500108] | 214,962 participants (Actual) | Observational | 2013-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for domperidone and Death, Sudden, Cardiac
| Article | Year |
|---|---|
Drug-induced Sudden Death: A Scoping Review.
Topics: Antipsychotic Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Humans; Risk Factor | 2023 |
Domperidone and the risks of sudden cardiac death and ventricular arrhythmia: A systematic review and meta-analysis of observational studies.
Topics: Antiemetics; Arrhythmias, Cardiac; Cross-Over Studies; Death, Sudden, Cardiac; Domperidone; Humans; | 2021 |
Domperidone for Hypotension in Parkinson's Disease: A Systematic Review.
Topics: Animals; Arrhythmias, Cardiac; Databases, Bibliographic; Death, Sudden, Cardiac; Domperidone; Dopami | 2017 |
Critical review of European Medicines Agency (EMA) assessment report and related literature on domperidone.
Topics: Antiemetics; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Humans; Metoclopramide; Risk | 2019 |
[Domperidone and the risk of sudden cardiac death].
Topics: Antiemetics; Case-Control Studies; Death, Sudden, Cardiac; Domperidone; Dose-Response Relationship, | 2013 |
[Cardiac adverse effects of domperidone in adult patients: a systematic review].
Topics: Adult; Antiemetics; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Female; Gastroesophag | 2015 |
Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations.
Topics: Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Death, Sudde | 2015 |
Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.
Topics: Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Case-Control | 2016 |
Domperidone and long QT syndrome.
Topics: Adult; Animals; Arrhythmias, Cardiac; Child; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonis | 2010 |
Domperidone: limited benefits with significant risk for sudden cardiac death.
Topics: Action Potentials; Animals; Antiemetics; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; | 2013 |
28 other studies available for domperidone and Death, Sudden, Cardiac
| Article | Year |
|---|---|
Domperidone increases harmful cardiac events in Parkinson's disease: A Bayesian re-analysis of an observational study.
Topics: Aged; Antiparkinson Agents; Bayes Theorem; Death, Sudden, Cardiac; Domperidone; Female; Humans; Male | 2021 |
Data variability across Canadian administrative health databases: Differences in content, coding, and completeness.
Topics: Antiemetics; Canada; Databases, Factual; Death, Sudden, Cardiac; Domperidone; Humans; Incidence; Int | 2020 |
Use of domperidone and risk of ventricular arrhythmia in the postpartum period: getting to the heart of the matter.
Topics: Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Female; Humans; Postpartum Period | 2017 |
Response to "use of domperidone and risk of ventricular arrhythmia in the postpartum period: Getting to the heart of the matter".
Topics: Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Female; Humans; Postpartum Period | 2017 |
Media attention regarding sudden cardiac death associated with domperidone use does not affect in hospital ECG recording.
Topics: Adult; Aged; Antiemetics; Cohort Studies; Death, Sudden, Cardiac; Domperidone; Drug Prescriptions; D | 2017 |
Domperidone for insufficient lactation in England 2002-2015: A drug utilization study with interrupted time series analysis.
Topics: Adult; Cohort Studies; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Dose-Response Rela | 2018 |
Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia.
Topics: Antiemetics; Arrhythmias, Cardiac; Clinical Decision-Making; Death, Sudden, Cardiac; Domperidone; Do | 2016 |
Awareness of, and Compliance with, Domperidone Revised Labeling After a Risk-Minimization Activity in Europe.
Topics: Adult; Antiemetics; Arrhythmias, Cardiac; Cardiac Conduction System Disease; Cross-Sectional Studies | 2019 |
[Domperidone: off the market or freely available?].
Topics: Antiemetics; Death, Sudden, Cardiac; Domperidone; Humans | 2013 |
French journal calls for domperidone to be withdrawn.
Topics: Adult; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; France; Humans; Periodicals as Top | 2014 |
Pharmacological management of low milk supply with domperidone: separating fact from fiction.
Topics: Age Factors; Arrhythmias, Cardiac; Breast Feeding; Death, Sudden, Cardiac; Domperidone; Dopamine Ant | 2014 |
Use of domperidone to increase breast milk supply: are women really dying to breastfeed?
Topics: Breast Feeding; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Female; Humans; Infant, N | 2014 |
Estimating the number of sudden cardiac deaths attributable to the use of domperidone in France.
Topics: Antiemetics; Data Interpretation, Statistical; Databases, Factual; Death, Sudden, Cardiac; Domperido | 2015 |
A case of sudden cardiac death following Domperidone self-medication.
Topics: Alcoholism; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperidone; Female; Gastrointestinal Agen | 2015 |
Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study.
Topics: Aging; Antiemetics; Case-Control Studies; Death, Sudden, Cardiac; Domperidone; Dose-Response Relatio | 2015 |
Domperidone, Parkinson disease and sudden cardiac death: Mice and men show the way.
Topics: Animals; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Humans; Mice; Models, Animal; Pa | 2016 |
Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiemetics; Canada; Cohort Studies; Death, Sudden, Cardiac; Domperidone; F | 2016 |
Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a "Black Box" Warning: A Canadian Tertiary Care Center Study.
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Domperido | 2016 |
Should Domperidone be Used as a Galactagogue? Possible Safety Implications for Mother and Child.
Topics: Breast Feeding; Death, Sudden, Cardiac; Domperidone; Dose-Response Relationship, Drug; Female; Galac | 2017 |
[Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Car | 2017 |
Domperidone and sudden death. Cardiac rhythm disorders: QT interval prolongation.
Topics: Antiemetics; Arrhythmias, Cardiac; Canada; Death, Sudden, Cardiac; Domperidone; Humans; Long QT Synd | 2008 |
Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database.
Topics: Arrhythmias, Cardiac; Cisapride; Cohort Studies; Databases, Factual; Death, Sudden, Cardiac; Domperi | 2008 |
Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Case-Contro | 2010 |
Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands.
Topics: Antiemetics; Case-Control Studies; Death, Sudden, Cardiac; Domperidone; Dose-Response Relationship, | 2010 |
Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death.
Topics: Action Potentials; Animals; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Heart Conduct | 2011 |
Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]?
Topics: Arrhythmias, Cardiac; Canada; Death, Sudden, Cardiac; Domperidone; Female; Galactogogues; Humans; La | 2012 |
Domperidone and sudden cardiac death: How much longer should we wait?
Topics: Animals; Antiemetics; Death, Sudden, Cardiac; Domperidone; Dopamine Antagonists; Female; Heart; Huma | 2013 |
Domperidone and sudden death.
Topics: Adult; Antiemetics; Brazil; Clinical Trials as Topic; Death, Sudden, Cardiac; Domperidone; Drug Appr | 2006 |