domperidone has been researched along with Critical Illness in 3 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Critical Illness: A disease or state in which death is possible or imminent.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, Y | 1 |
| He, Z | 1 |
| Long, Y | 1 |
| Chen, W | 2 |
| Chen, D | 1 |
| Chi, R | 1 |
| Ye, H | 2 |
| Deng, X | 1 |
| Lv, B | 1 |
| Sun, C | 2 |
| Hu, B | 2 |
| Nie, Z | 2 |
| Gu, S | 1 |
| Chen, C | 2 |
| Zhang, Y | 1 |
| Lao, Z | 1 |
| Wu, F | 1 |
| Liu, Z | 2 |
| Huang, L | 1 |
| Qu, C | 1 |
| Xian, L | 1 |
| Wu, H | 1 |
| Jiao, Y | 1 |
| Liu, J | 1 |
| Cai, J | 1 |
| Lewis, K | 1 |
| Alqahtani, Z | 1 |
| Mcintyre, L | 1 |
| Almenawer, S | 1 |
| Alshamsi, F | 1 |
| Rhodes, A | 1 |
| Evans, L | 1 |
| Angus, DC | 1 |
| Alhazzani, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Metoclopramide Versus Placebo During Gastrojejunostomy Tube Placement for Facilitating Guidewire Advancement Through the Pylorus[NCT03331965] | Phase 2 | 110 participants (Actual) | Interventional | 2018-04-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To assess the safety of a single dose of promotility agent prior to GJ tube placement by assessing rates of adverse events in the periprocedural period in patients receiving IV metoclopramide versus placebo. (NCT03331965)
Timeframe: Up to 30 days after procedure.
| Intervention | Participants (Count of Participants) |
|---|---|
| Metoclopramide | 0 |
| Saline | 0 |
The fluoroscopy time required to advance a guidewire through the pylorus. (NCT03331965)
Timeframe: Up to 45 minutes.
| Intervention | Minutes (Mean) |
|---|---|
| Metoclopramide | 1.6 |
| Saline | 4.1 |
The total procedure Air Kerma (energy released in a unit mass of air) measured in milligray (mGy). (NCT03331965)
Timeframe: Up to 1 hour.
| Intervention | mGy (Mean) |
|---|---|
| Metoclopramide | 91 |
| Saline | 130 |
The total procedure fluoroscopy time. (NCT03331965)
Timeframe: Up to 1 hour.
| Intervention | Minutes (Mean) |
|---|---|
| Metoclopramide | 5.8 |
| Saline | 8.8 |
The total procedure time. (NCT03331965)
Timeframe: Up to 1 hour.
| Intervention | Minutes (Mean) |
|---|---|
| Metoclopramide | 16.4 |
| Saline | 19.9 |
1 review available for domperidone and Critical Illness
| Article | Year |
|---|---|
The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials.
Topics: Chi-Square Distribution; Critical Illness; Diarrhea; Domperidone; Dopamine Antagonists; Enteral Nutr | 2016 |
2 trials available for domperidone and Critical Illness
| Article | Year |
|---|---|
Simo decoction versus domperidone suspension for post-pyloric spiral nasoenteric tube placement: A multicenter, randomized, non-inferiority trial.
Topics: Aged; Critical Illness; Domperidone; Drugs, Chinese Herbal; Enteral Nutrition; Female; Humans; Inten | 2020 |
Metoclopramide or domperidone improves post-pyloric placement of spiral nasojejunal tubes in critically ill patients: a prospective, multicenter, open-label, randomized, controlled clinical trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; APACHE; Critical Illness; Domperidone; Ente | 2015 |