domperidone has been researched along with Chronic Disease in 19 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was no additional effect of domperidone as adjunct to PEG in the treatment of children with constipation." | 9.19 | Oral domperidone has no additional effect on chronic functional constipation in children: a randomized clinical trial. ( Askarian, M; Dehghani, SM; Kaffashan, HA, 2014) |
| "A double-blind, placebo-controlled trial was performed to determine the therapeutic efficacy of cisapride in patients with refractory functional dyspepsia." | 9.07 | Efficacy of cisapride in functional dyspepsia resistant to domperidone or metoclopramide: a double-blind, placebo-controlled study. ( De Nutte, N; Gooris, JP; Van Eeghem, P; Van Outryve, M, 1993) |
| "There was no additional effect of domperidone as adjunct to PEG in the treatment of children with constipation." | 5.19 | Oral domperidone has no additional effect on chronic functional constipation in children: a randomized clinical trial. ( Askarian, M; Dehghani, SM; Kaffashan, HA, 2014) |
| "A double-blind, placebo-controlled trial was performed to determine the therapeutic efficacy of cisapride in patients with refractory functional dyspepsia." | 5.07 | Efficacy of cisapride in functional dyspepsia resistant to domperidone or metoclopramide: a double-blind, placebo-controlled study. ( De Nutte, N; Gooris, JP; Van Eeghem, P; Van Outryve, M, 1993) |
| "The effects on gastric emptying and gastrointestinal symptoms of treatment with cisapride alone and in combination with domperidone were investigated in 25 patients with chronic idiopathic dyspepsia." | 5.07 | Effect of treatment with cisapride alone or in combination with domperidone on gastric emptying and gastrointestinal symptoms in dyspeptic patients. ( Iishi, H; Nakaizumi, A; Okuda, S; Tatsuta, M, 1992) |
| "The effects of domperidone, a peripherally acting dopamine antagonist, were compared with those of placebo in a double-blind randomized study in 16 patients with idiopathic gastric stasis, chronic symptoms of "nonulcer dyspepsia" (including nausea, vomiting, and abdominal pain), and altered gastroduodenal motility." | 5.06 | Effects of domperidone in patients with chronic unexplained upper gastrointestinal symptoms: a double-blind, placebo-controlled study. ( Clench, MH; Davis, RH; Mathias, JR, 1988) |
| "In patients with advanced cancer not being treated with chemotherapy or radiation therapy, metoclopramide can be used to reduce nausea and vomiting." | 4.88 | [Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients : a review]. ( Alt-Epping, B; Benze, G; Geyer, A; Nauck, F, 2012) |
| "Clinical symptoms, cough symptom score, capsaicin cough sensitivity, gastroesophageal reflux diagnostic questionnaire (GerdQ) score, findings of multichannel intraluminal impedance-pH monitoring (MII-pH) and response to pharmacological anti-reflux therapy were retrospectively reviewed in 38 patients with non-acid GERC and compared with those of 49 patients with acid GERC." | 3.81 | Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux. ( Chen, Q; Liang, S; Lü, H; Qiu, Z; Xu, X; Yang, Z; Yu, L, 2015) |
| "Inflammatory edema was induced by carrageenan in male rats, and hyperprolactinemia was induced by injections of the dopamine receptor antagonist domperidone." | 3.76 | Acute and chronic stress and the inflammatory response in hyperprolactinemic rats. ( Carvalho-Freitas, MI; Cruz-Casallas, PE; Felicio, LF; Malucelli, BE; Nasello, AG; Ochoa-Amaya, JE, 2010) |
| " Peripheral chemoreceptor effects on ventilation were evaluated by exposing animals to hyperoxia (Dejours test) and domperidone, a peripheral ventilatory stimulant drug directly affecting the carotid sinus nerve discharge." | 3.74 | Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. ( Borter, E; Gassmann, M; Soliz, J; Soulage, C; van Patot, MT, 2008) |
| " Secondary end-points were the rate of control of chronic cough at each step of therapy, the duration of treatment required, changes in cough symptom score, health-related quality of life and possible adverse effects." | 2.75 | Efficacy and safety of modified sequential three-step empirical therapy for chronic cough. ( Li, X; Liang, S; Liu, B; Lü, H; Qiu, Z; Wang, L; Wang, Y; Wei, W; Yu, L, 2010) |
| "Functional vomiting is rare and presents with more frequent vomiting episodes." | 2.44 | Functional nausea and vomiting. ( Talley, NJ, 2007) |
| "Dyspepsia affects one in four Australians; of those who present in general practice, the majority will have functional or non-ulcer dyspepsia, with no structural explanation for their symptoms." | 2.39 | Modern management of dyspepsia. ( Talley, NJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dehghani, SM | 1 |
| Askarian, M | 1 |
| Kaffashan, HA | 1 |
| Xu, X | 1 |
| Yang, Z | 1 |
| Chen, Q | 1 |
| Yu, L | 2 |
| Liang, S | 2 |
| Lü, H | 2 |
| Qiu, Z | 3 |
| Soliz, J | 1 |
| Soulage, C | 1 |
| Borter, E | 1 |
| van Patot, MT | 1 |
| Gassmann, M | 1 |
| Ochoa-Amaya, JE | 1 |
| Malucelli, BE | 1 |
| Cruz-Casallas, PE | 1 |
| Nasello, AG | 1 |
| Felicio, LF | 1 |
| Carvalho-Freitas, MI | 1 |
| Wei, W | 1 |
| Wang, Y | 1 |
| Li, X | 1 |
| Wang, L | 1 |
| Liu, B | 1 |
| Benze, G | 1 |
| Alt-Epping, B | 1 |
| Geyer, A | 1 |
| Nauck, F | 1 |
| Gamboa, J | 1 |
| Macarlupú, JL | 1 |
| Rivera-Chira, M | 1 |
| Monge-C, C | 1 |
| León-Velarde, F | 1 |
| Arnulf, I | 1 |
| Konofal, E | 1 |
| Gauthier, C | 1 |
| Chedru, F | 1 |
| Talley, NJ | 2 |
| Nagler, J | 1 |
| Miskovitz, P | 1 |
| Van Outryve, M | 1 |
| De Nutte, N | 1 |
| Van Eeghem, P | 1 |
| Gooris, JP | 1 |
| Tatsumi, K | 1 |
| Pickett, CK | 1 |
| Weil, JV | 1 |
| Tatsuta, M | 1 |
| Iishi, H | 1 |
| Nakaizumi, A | 1 |
| Okuda, S | 1 |
| Nerozzi, D | 1 |
| Magnani, A | 1 |
| Dastoli, C | 1 |
| Ferri, E | 1 |
| Capesciotti, G | 1 |
| Antonozzi, I | 1 |
| Frajese, G | 1 |
| Meltzer, HY | 1 |
| Wach, RA | 1 |
| Bee, D | 1 |
| Barer, GR | 1 |
| Dupont, C | 1 |
| Molkhou, P | 1 |
| Petrovic, N | 1 |
| Fraitag, B | 1 |
| Davis, RH | 1 |
| Clench, MH | 1 |
| Mathias, JR | 1 |
| Hordijk, ML | 1 |
| van Roon, F | 1 |
| Silberbusch, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Controlled Pilot Trial of Domperidone in Relapsing-Remitting Multiple Sclerosis[NCT02493049] | Phase 2 | 17 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for domperidone and Chronic Disease
| Article | Year |
|---|---|
[Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients : a review].
Topics: Antiemetics; Antipsychotic Agents; Chronic Disease; Domperidone; Dopamine Antagonists; Drug Therapy, | 2012 |
Functional nausea and vomiting.
Topics: Acute Disease; Antidepressive Agents, Tricyclic; Antiemetics; Chronic Disease; Diagnosis, Differenti | 2007 |
Modern management of dyspepsia.
Topics: Adult; Aged; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bismuth; Child; C | 1996 |
6 trials available for domperidone and Chronic Disease
| Article | Year |
|---|---|
Oral domperidone has no additional effect on chronic functional constipation in children: a randomized clinical trial.
Topics: Administration, Oral; Child; Child, Preschool; Chronic Disease; Constipation; Domperidone; Dopamine | 2014 |
Efficacy and safety of modified sequential three-step empirical therapy for chronic cough.
Topics: Adult; Aminophylline; Antitussive Agents; Budesonide; Cetirizine; Chlorpheniramine; Chronic Disease; | 2010 |
Clinical evaluation of domperidone in the treatment of chronic postprandial idiopathic upper gastrointestinal distress.
Topics: Chronic Disease; Clinical Trials as Topic; Domperidone; Double-Blind Method; Eating; Erythema; Gastr | 1981 |
Efficacy of cisapride in functional dyspepsia resistant to domperidone or metoclopramide: a double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Cisapride; Domperidone; Double-Blind Method; Dyspepsia; Fe | 1993 |
Effect of treatment with cisapride alone or in combination with domperidone on gastric emptying and gastrointestinal symptoms in dyspeptic patients.
Topics: Chronic Disease; Cisapride; Domperidone; Double-Blind Method; Drug Therapy, Combination; Dyspepsia; | 1992 |
Effects of domperidone in patients with chronic unexplained upper gastrointestinal symptoms: a double-blind, placebo-controlled study.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Domperidone; Double-Blind Method; Dyspepsia; Femal | 1988 |
10 other studies available for domperidone and Chronic Disease
| Article | Year |
|---|---|
Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux.
Topics: Adult; Anti-Ulcer Agents; Baclofen; Capsaicin; Chronic Disease; Cough; Domperidone; Esophageal pH Mo | 2015 |
Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice.
Topics: Acclimatization; Acute Disease; Animals; Body Temperature; Carotid Body; Chronic Disease; Disease Mo | 2008 |
Acute and chronic stress and the inflammatory response in hyperprolactinemic rats.
Topics: Acute Disease; Animals; Carrageenan; Chronic Disease; Cold Temperature; Disease Models, Animal; Domp | 2010 |
Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats.
Topics: Animals; Chronic Disease; Domperidone; Dopamine Antagonists; Hemoglobins; Hypoxia; Male; Polycythemi | 2003 |
Severe restless legs syndrome presenting as intractable insomnia.
Topics: Chronic Disease; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, D | 2004 |
Decreased carotid body hypoxic sensitivity in chronic hypoxia: role of dopamine.
Topics: Anesthesia; Animals; Carotid Body; Carotid Sinus; Cats; Chronic Disease; Domperidone; Dopamine; Dopa | 1995 |
Prolactin responses to domperidone in chronic schizophrenia.
Topics: Aged; Chronic Disease; Domperidone; Humans; Male; Middle Aged; Prolactin; Psychiatric Status Rating | 1992 |
Dopamine and ventilatory effects of hypoxia and almitrine in chronically hypoxic rats.
Topics: Almitrine; Animals; Central Nervous System Stimulants; Chronic Disease; Domperidone; Dopamine Antago | 1989 |
[Treatment using Motilium of gastro-esophageal reflux associated with respiratory manifestations in children].
Topics: Asthma; Bronchitis; Child; Child, Preschool; Chronic Disease; Cough; Domperidone; Gastroesophageal R | 1989 |
Domperidone decreases duodenogastric reflux in patients with chronic gastritis.
Topics: Adult; Aged; Chronic Disease; Domperidone; Duodenogastric Reflux; Female; Gastritis; Humans; Male; M | 1987 |