domperidone has been researched along with Cholera Infantum in 32 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate the therapeutic effect of domperidone on children with abdominal pain predominant functional gastrointestinal disorders (AP-FGIDs)." | 9.27 | Randomized Controlled Clinical Trial on Value of Domperidone in Functional Abdominal Pain in Children. ( de Silva, A; Devanarayana, NM; Gunawardena, S; Karunanayake, A; Rajindrajith, S, 2018) |
| "Domperidone is a dopamine antagonist that does not readily enter the central nervous system." | 6.36 | Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. ( Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Speight, TM, 1982) |
| "The aim of the study was to evaluate the therapeutic effect of domperidone on children with abdominal pain predominant functional gastrointestinal disorders (AP-FGIDs)." | 5.27 | Randomized Controlled Clinical Trial on Value of Domperidone in Functional Abdominal Pain in Children. ( de Silva, A; Devanarayana, NM; Gunawardena, S; Karunanayake, A; Rajindrajith, S, 2018) |
| "symptoms of disordered upper gastrointestinal motor activity may be mistaken as indicating primary anorexia nervosa; clinical evaluation of patients with presumed primary anorexia nervosa should rule out the possibility that disordered oesophageal motor activity underlies the symptoms; delayed gastric emptying is a frequent feature in primary anorexia nervosa and might be returned to normal with domperidone." | 5.06 | Oesophageal and gastric motility disorders in patients categorised as having primary anorexia nervosa. ( Bergmann, H; Höbart, J; Kiss, A; Schneider, C; Stacher, G; Wiesnagrotzki, S, 1986) |
| "To review the pharmacology, pharmacokinetics, efficacy, and safety of domperidone in the treatment of gastrointestinal motility disorders and emesis." | 4.80 | Domperidone: a peripherally acting dopamine2-receptor antagonist. ( Barone, JA, 1999) |
| "Domperidone, a peripheral D2 dopamine receptor antagonist, has efficacy for treatment of nausea, dyspepsia, and gastroparesis." | 3.85 | Domperidone is Commonly Prescribed With QT-Interacting Drugs: Review of a Community-based Practice and a Postmarketing Adverse Drug Event Reporting Database. ( Alexoff, A; Ehrenpreis, ED; Roginsky, G; Smith, DG, 2017) |
| "Several cases of QT prolongation and ventricular tachyarrhythmia have been reported with domperidone, a gastrokinetic and antiemetic agent available worldwide but still under investigation in the United States." | 3.70 | Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders. ( Cardinal, R; Daleau, P; Drolet, B; Rousseau, G; Turgeon, J, 2000) |
| "Domperidone is a peripheral dopamine-2 receptor antagonist with prokinetic and antiemetic properties." | 3.01 | Drugs in Focus: Domperidone. ( Assa, A; Benninga, M; Borrelli, O; Broekaert, IJ; Carpi, FJM; Deganello Saccomani, M; Dolinsek, J; Homan, M; Mas, E; Miele, E; Puoti, MG; Thomson, M; Tzivinikos, C, 2023) |
| "Patients' global assessment of Parkinson's disease remained stable or improved." | 2.68 | Effect of chronic oral domperidone therapy on gastrointestinal symptoms and gastric emptying in patients with Parkinson's disease. ( McCallum, RW; Sarosiek, I; Shifflett, J; Soykan, I; Wooten, GF, 1997) |
| "Severity of headache, duration of migraine attack and overall efficacy of treatment were amongst the variables assessed in a randomized, double-blind, three-way cross-over comparison of 1 g paracetamol plus either domperidone 30 mg, domperidone 20 mg or placebo, taken at onset of headache." | 2.67 | Domperidone plus paracetamol in the treatment of migraine. ( Bancroft, K; MacGregor, EA; Wilkinson, M, 1993) |
| "Domperidone is a dopamine-2 receptor antagonist." | 2.44 | Domperidone: review of pharmacology and clinical applications in gastroenterology. ( McCallum, RW; Reddymasu, SC; Soykan, I, 2007) |
| "Domperidone, which has also been shown to stimulate gastric motility and to possess antiemetic properties, improves symptoms in patients suffering from diabetic gastroparesis." | 2.38 | Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis. ( Brown, CK; Khanderia, U, 1990) |
| "Domperidone is a dopamine antagonist that does not readily enter the central nervous system." | 2.36 | Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. ( Avery, GS; Brogden, RN; Carmine, AA; Heel, RC; Speight, TM, 1982) |
| "The risk of serious ventricular arrhythmias (SVA) in clinical practice in China has not been investigated." | 1.56 | Risk of Serious Ventricular Arrhythmia in Users of Gastrointestinal Medications: A Retrospective Cohort Study in China. ( Jiang, K; Liang, W; Qiu, H; Shu, M; Wu, K; Zhang, D; Zhang, Y, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (28.13) | 18.7374 |
| 1990's | 7 (21.88) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Scorza, FA | 1 |
| de Almeida, AG | 1 |
| Scorza, CA | 1 |
| Finsterer, J | 1 |
| Puoti, MG | 1 |
| Assa, A | 1 |
| Benninga, M | 1 |
| Broekaert, IJ | 1 |
| Carpi, FJM | 1 |
| Deganello Saccomani, M | 1 |
| Dolinsek, J | 1 |
| Homan, M | 1 |
| Mas, E | 1 |
| Miele, E | 1 |
| Tzivinikos, C | 1 |
| Thomson, M | 1 |
| Borrelli, O | 1 |
| Zhang, Y | 1 |
| Shu, M | 1 |
| Liang, W | 1 |
| Jiang, K | 1 |
| Zhang, D | 1 |
| Qiu, H | 1 |
| Wu, K | 1 |
| Sukwuttichai, P | 1 |
| Boonkasidecha, S | 1 |
| Montakantikul, P | 1 |
| Vimolsarawong, N | 1 |
| Madisch, A | 1 |
| Vinson, BR | 1 |
| Abdel-Aziz, H | 1 |
| Kelber, O | 1 |
| Nieber, K | 1 |
| Kraft, K | 1 |
| Storr, M | 1 |
| Karunanayake, A | 1 |
| Devanarayana, NM | 1 |
| de Silva, A | 1 |
| Gunawardena, S | 1 |
| Rajindrajith, S | 1 |
| Lertxundi, U | 1 |
| Domingo-Echaburu, S | 1 |
| Soraluce, A | 1 |
| García, M | 1 |
| Ruiz-Osante, B | 1 |
| Aguirre, C | 1 |
| Chang, X | 1 |
| Wang, S | 1 |
| Bao, YR | 1 |
| Li, TJ | 1 |
| Yu, XM | 1 |
| Meng, XS | 1 |
| Ehrenpreis, ED | 1 |
| Roginsky, G | 1 |
| Alexoff, A | 1 |
| Smith, DG | 1 |
| Gounaris, A | 1 |
| Costalos, C | 1 |
| Varchalama, E | 1 |
| Kokori, F | 1 |
| Grivea, IN | 1 |
| Konstantinidi, K | 1 |
| Syrogiannopoulos, GA | 1 |
| Aleksseva, EV | 1 |
| Fominykh, VP | 1 |
| Tropskaia, NS | 1 |
| Popova, TS | 1 |
| Ahmad, N | 1 |
| Keith-Ferris, J | 1 |
| Gooden, E | 1 |
| Abell, T | 1 |
| Reddymasu, SC | 1 |
| Soykan, I | 2 |
| McCallum, RW | 3 |
| Hanauer, SB | 1 |
| Robinson, P | 1 |
| Weihrauch, TR | 1 |
| Kilbinger, H | 1 |
| Brogden, RN | 1 |
| Carmine, AA | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Nagler, J | 1 |
| Miskovitz, P | 1 |
| MacGregor, EA | 1 |
| Wilkinson, M | 1 |
| Bancroft, K | 1 |
| Brignoli, R | 1 |
| Watkins, P | 1 |
| Halter, F | 1 |
| Sarosiek, I | 1 |
| Shifflett, J | 1 |
| Wooten, GF | 1 |
| Sheptulin, AA | 1 |
| Barone, JA | 1 |
| Drolet, B | 1 |
| Rousseau, G | 1 |
| Daleau, P | 1 |
| Cardinal, R | 1 |
| Turgeon, J | 1 |
| Varga, A | 1 |
| Lovas, J | 1 |
| Brown, CK | 1 |
| Khanderia, U | 1 |
| Vadász, I | 1 |
| Kis Csitári, I | 1 |
| Huber, G | 1 |
| Stacher, G | 1 |
| Kiss, A | 1 |
| Wiesnagrotzki, S | 1 |
| Bergmann, H | 1 |
| Höbart, J | 1 |
| Schneider, C | 1 |
| Friedman, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Investigational New Drug Program for the Use of Domperidone in the Treatment of Refractory Gastroesophageal Reflux Disease and Other Gastrointestinal Motility Disorders[NCT00777439] | 75 participants (Anticipated) | Interventional | 2008-10-31 | Recruiting | |||
| Oral Domperidone for Relief of Gastrointestinal Disorders in Patients Who Failed Standard Therapy[NCT00761254] | 42 participants (Actual) | Interventional | 2008-08-31 | Terminated (stopped due to PI withdrew due to increased responsibilities in clinical department.) | |||
| Does Domperidone, a D2-antagonist Alter Gastric Emptying Rates and Appetite Sensations in Healthy Adults?[NCT01347814] | 13 participants (Actual) | Interventional | 2008-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for domperidone and Cholera Infantum
| Article | Year |
|---|---|
Drugs in Focus: Domperidone.
Topics: Antiemetics; Child; Domperidone; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Infant; | 2023 |
Modulation of gastrointestinal motility beyond metoclopramide and domperidone : Pharmacological and clinical evidence for phytotherapy in functional gastrointestinal disorders.
Topics: Domperidone; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Irritable Bowel Syndrome; | 2017 |
Making a case for domperidone in the treatment of gastrointestinal motility disorders.
Topics: Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Ran | 2006 |
Making a case for domperidone in the treatment of gastrointestinal motility disorders.
Topics: Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Ran | 2006 |
Making a case for domperidone in the treatment of gastrointestinal motility disorders.
Topics: Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Ran | 2006 |
Making a case for domperidone in the treatment of gastrointestinal motility disorders.
Topics: Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Ran | 2006 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
Domperidone: review of pharmacology and clinical applications in gastroenterology.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Humans; Nausea; Vomiting | 2007 |
[Motility-effective drugs for therapy of gastrointestinal functional disorders].
Topics: Bethanechol Compounds; Carbachol; Domperidone; Esophagitis, Peptic; Gastrointestinal Diseases; Gastr | 1982 |
Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.
Topics: Antiemetics; Domperidone; Dyspepsia; Endocrine Glands; Gastrointestinal Diseases; Hemodynamics; Huma | 1982 |
[Kinetic drug Motilium: pharmacological properties and potential clinical use].
Topics: Domperidone; Dopamine Antagonists; Gastrointestinal Diseases; Gastrointestinal Motility; Humans | 1997 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Domperidone: a peripherally acting dopamine2-receptor antagonist.
Topics: Animals; Data Collection; Diabetes Mellitus; Domperidone; Dopamine Antagonists; Drug Interactions; G | 1999 |
Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis.
Topics: Cisapride; Diabetes Complications; Domperidone; Gastric Emptying; Gastrointestinal Diseases; Humans; | 1990 |
7 trials available for domperidone and Cholera Infantum
| Article | Year |
|---|---|
Randomized Controlled Clinical Trial on Value of Domperidone in Functional Abdominal Pain in Children.
Topics: Abdominal Pain; Child; Child, Preschool; Domperidone; Dopamine Antagonists; Double-Blind Method; Fem | 2018 |
Gastric emptying of preterm neonates receiving domperidone.
Topics: Antiemetics; Apgar Score; Birth Weight; Cross-Over Studies; Domperidone; Female; Gastric Emptying; G | 2010 |
Clinical evaluation of domperidone in the treatment of chronic postprandial idiopathic upper gastrointestinal distress.
Topics: Chronic Disease; Clinical Trials as Topic; Domperidone; Double-Blind Method; Eating; Erythema; Gastr | 1981 |
Domperidone plus paracetamol in the treatment of migraine.
Topics: Acetaminophen; Adolescent; Adult; Aged; Domperidone; Double-Blind Method; Drug Combinations; Female; | 1993 |
The Omega-Project--a comparison of two diagnostic strategies for risk- and cost-oriented management of dyspepsia.
Topics: Adult; Cisapride; Costs and Cost Analysis; Domperidone; Dopamine Antagonists; Double-Blind Method; D | 1997 |
Effect of chronic oral domperidone therapy on gastrointestinal symptoms and gastric emptying in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Bromocriptine; Carbidopa; Domperidone; Dopamine Antagonists; Drug Therap | 1997 |
Oesophageal and gastric motility disorders in patients categorised as having primary anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Diagnosis, Differential; Domperidone; Esophageal Diseases; Fema | 1986 |
16 other studies available for domperidone and Cholera Infantum
| Article | Year |
|---|---|
Gastrointestinal dysfunctions and sudden death in Parkinson patients: domperidone in FOCUS.
Topics: Death, Sudden; Domperidone; Gastrointestinal Diseases; Humans; Parkinson Disease | 2023 |
Risk of Serious Ventricular Arrhythmia in Users of Gastrointestinal Medications: A Retrospective Cohort Study in China.
Topics: Administration, Oral; Adult; Antiemetics; Arrhythmias, Cardiac; China; Databases, Factual; Domperido | 2020 |
Efficacy comparison between oral erythromycin versus domperidone for the treatment of feeding intolerance in preterm neonates.
Topics: Child; Domperidone; Erythromycin; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointestin | 2021 |
Domperidone in Parkinson's disease: a perilous arrhythmogenic or the gold standard?
Topics: Administration, Oral; Antiparkinson Agents; Domperidone; Dopamine Antagonists; Dose-Response Relatio | 2013 |
Multicomponent, multitarget integrated adjustment - Metabolomics study of Qizhiweitong particles curing gastrointestinal motility disorders in mice induced by atropine.
Topics: Animals; Atropine; Benzamides; Biomarkers; Chromatography, High Pressure Liquid; Chromatography, Liq | 2016 |
Domperidone is Commonly Prescribed With QT-Interacting Drugs: Review of a Community-based Practice and a Postmarketing Adverse Drug Event Reporting Database.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antiemetics; Domperidone; D | 2017 |
[Use of the prokinetic domperidine in patients in the early postoperative period].
Topics: Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fema | 2010 |
Moving ahead or falling behind?
Topics: Cisapride; Constipation; Domperidone; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointe | 2007 |
Dosage and drug interactions of domperidone.
Topics: Antiemetics; Domperidone; Dopamine Antagonists; Drug Interactions; Drug Labeling; Gastrointestinal D | 2008 |
Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders.
Topics: Action Potentials; Animals; Antiemetics; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cation Tr | 2000 |
Some possible gynaecological indications for peripheral antidopamine therapy.
Topics: Adult; Climacteric; Domperidone; Drug Evaluation; Dyspepsia; Female; Gastrointestinal Diseases; Huma | 1992 |
Examination of Motilium in the prevention of gastro-intestinal side-effects of different drugs used in pulmonology.
Topics: Adult; Aged; Antineoplastic Agents; Domperidone; Female; Gastrointestinal Diseases; Humans; Lung Dis | 1988 |
Use of peripheral dopamine receptor antagonist in gynaecology in certain borderline cases.
Topics: Climacteric; Domperidone; Dyspepsia; Female; Gastrointestinal Diseases; Humans; Migraine Disorders; | 1987 |
Treatment of gastro-intestinal complaints accompanying menopause with Motilium film-coated tablet.
Topics: Adult; Climacteric; Domperidone; Dyspepsia; Female; Gastrointestinal Diseases; Humans; Middle Aged | 1987 |
New drugs in gastroenterology.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antidiarrheals; Colit | 1985 |
Review of the current status of prokinetic agents in gastroenterology.
Topics: Benzamides; Chemical Phenomena; Chemistry; Cisapride; Dexamethasone; Digestive System; Domperidone; | 1985 |